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UPB Insider Trading

Insider Ownership Percentage: 13.56%
Insider Buying (Last 12 Months): $0.00
Insider Selling (Last 12 Months): $0.00

Upstream Bio Insider Trading History Chart

This chart shows the insider buying and selling history at Upstream Bio by year and by quarter.

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Upstream Bio Share Price & Price History

Current Price: $7.92
Price Change: ▼ Price Decrease of -0.1 (-1.25%)
As of 02/24/2026 05:00 PM ET

This chart shows the closing price history over time for UPB up to the past year.

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Days: 30 | 90 | 365

Upstream Bio Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
10/15/2024Ai Upstream LlcMajor ShareholderBuy1,175,000$17.00$19,975,000.001,175,000View SEC Filing Icon  
10/15/2024Erez ChimovitsDirectorBuy825,000$17.00$14,025,000.004,554,873View SEC Filing Icon  
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SEC Filings (Institutional Ownership Changes) for Upstream Bio (NASDAQ:UPB)

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at UPB by year and by quarter.

Skip Institutional Buying and Selling Chart and Table DataRead Chart Data in Institutional Trading History Table

Upstream Bio Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
2/23/2026Virtu Financial LLC12,246$0.33M0.0%N/A0.023%Search for SEC Filing on Google Icon
2/19/2026Invesco Ltd.163,186$4.43M0.0%+849.3%0.302%Search for SEC Filing on Google Icon
2/18/2026Empowered Funds LLC1,647$45K0.0%N/A0.003%Search for SEC Filing on Google Icon
2/18/2026XTX Topco Ltd15,091$0.41M0.0%N/A0.028%Search for SEC Filing on Google Icon
2/18/2026VARCOV Co.9,619$0.26M0.1%N/A0.018%Search for SEC Filing on Google Icon
2/18/2026Vestal Point Capital LP720,000$19.55M0.7%N/A1.332%Search for SEC Filing on Google Icon
2/18/2026Wellington Management Group LLP894,733$24.29M0.0%-20.5%1.656%Search for SEC Filing on Google Icon
2/18/2026Squadron Capital Management LLC230,650$6.26M2.7%N/A0.427%Search for SEC Filing on Google Icon
2/18/2026SummitTX Capital L.P.116,724$3.17M0.1%+3.8%0.216%Search for SEC Filing on Google Icon
2/18/2026Millennium Management LLC517,264$14.04M0.0%+1,189.5%0.957%Search for SEC Filing on Google Icon
2/18/2026Janus Henderson Group PLC1,527,958$41.42M0.0%N/A2.827%Search for SEC Filing on Google Icon
2/18/2026Artia Global Partners LP68,653$1.86M0.3%N/A0.127%Search for SEC Filing on Google Icon
2/18/2026Altshuler Shaham Ltd1,341,540$36.42M0.5%-5.3%2.482%Search for SEC Filing on Google Icon
2/17/2026Schonfeld Strategic Advisors LLC115,807$3.14M0.0%-39.1%0.214%Search for SEC Filing on Google Icon
2/17/2026Bain Capital Life Sciences Investors LLC1,329,544$36.10M2.8%-45.5%2.460%Search for SEC Filing on Google Icon
2/17/2026Trexquant Investment LP31,049$0.84M0.0%N/A0.057%Search for SEC Filing on Google Icon
2/17/2026Integral Health Asset Management LLC750,000$20.36M1.0%+30.4%1.388%Search for SEC Filing on Google Icon
2/17/2026California State Teachers Retirement System14,652$0.40M0.0%+573.3%0.027%Search for SEC Filing on Google Icon
2/17/2026Diadema Partners LP20,500$0.56M0.1%-89.8%0.038%Search for SEC Filing on Google Icon
2/17/2026Omega Fund Management LLC1,326,293$36.01M12.6%-2.2%2.454%Search for SEC Filing on Google Icon
2/17/2026ExodusPoint Capital Management LP75,402$2.05M0.0%N/A0.140%Search for SEC Filing on Google Icon
2/17/2026Graham Capital Management L.P.13,712$0.37M0.0%N/A0.025%Search for SEC Filing on Google Icon
2/17/2026Persistent Asset Partners Ltd8,907$0.24M0.1%N/A0.016%Search for SEC Filing on Google Icon
2/16/2026Verition Fund Management LLC12,020$0.33M0.0%-74.4%0.022%Search for SEC Filing on Google Icon
2/16/2026Barclays PLC524,499$14.24M0.0%+514.8%0.971%Search for SEC Filing on Google Icon
2/13/2026Nantahala Capital Management LLC494,971$13.44M0.4%-16.8%0.916%Search for SEC Filing on Google Icon
2/13/2026Marshall Wace LLP343,791$9.33M0.0%-60.4%0.636%Search for SEC Filing on Google Icon
2/13/2026The Manufacturers Life Insurance Company 10,147$0.28M0.0%-16.1%0.019%Search for SEC Filing on Google Icon
2/13/2026Exome Asset Management LLC64,845$1.76M0.8%+24.8%0.120%Search for SEC Filing on Google Icon
2/13/2026Rafferty Asset Management LLC38,683$1.05M0.0%+12.1%0.072%Search for SEC Filing on Google Icon
2/13/2026Alyeska Investment Group L.P.298,329$8.10M0.0%N/A0.552%Search for SEC Filing on Google Icon
2/13/2026Siren L.L.C.588,450$15.98M0.5%-25.4%1.089%Search for SEC Filing on Google Icon
2/13/2026State Street Corp1,319,226$35.82M0.0%+18.4%2.441%Search for SEC Filing on Google Icon
2/13/2026Wells Fargo & Company MN36,794$1M0.0%+46.2%0.068%Search for SEC Filing on Google Icon
2/12/2026MetLife Investment Management LLC19,678$0.53M0.0%-9.3%0.036%Search for SEC Filing on Google Icon
2/12/2026Renaissance Technologies LLC16,400$0.45M0.0%N/A0.030%Search for SEC Filing on Google Icon
2/12/2026Decheng Capital LLC3,143,078$85.34M11.5%-4.3%5.816%Search for SEC Filing on Google Icon
2/12/2026New York State Common Retirement Fund11,700$0.32M0.0%+85.7%0.022%Search for SEC Filing on Google Icon
2/12/2026Alps Advisors Inc.44,376$1.21M0.0%+70.9%0.082%Search for SEC Filing on Google Icon
2/12/2026Swiss National Bank26,600$0.72M0.0%N/A0.049%Search for SEC Filing on Google Icon
2/12/2026Nuveen LLC78,568$2.13M0.0%+12.4%0.145%Search for SEC Filing on Google Icon
2/11/2026Empowered Funds LLC1,647$45K0.0%N/A0.003%Search for SEC Filing on Google Icon
2/11/2026Deutsche Bank AG127,815$3.47M0.0%+378.0%0.237%Search for SEC Filing on Google Icon
2/10/2026Goldman Sachs Group Inc.333,481$9.05M0.0%+49.4%0.617%Search for SEC Filing on Google Icon
2/10/2026Norges Bank2,882,647$78.26M0.0%N/A5.334%Search for SEC Filing on Google Icon
2/10/2026Seven Grand Managers LLC50,000$1.36M0.1%N/A0.093%Search for SEC Filing on Google Icon
2/9/2026Geode Capital Management LLC851,908$23.13M0.0%+4.3%1.576%Search for SEC Filing on Google Icon
2/6/2026PSP Research LLC17,634$0.48M0.4%N/A0.033%Search for SEC Filing on Google Icon
2/6/2026ProShare Advisors LLC8,354$0.23M0.0%N/A0.015%Search for SEC Filing on Google Icon
2/5/2026DNB Asset Management AS12,793$0.35M0.0%N/A0.024%Search for SEC Filing on Google Icon
2/2/2026Strs Ohio9,800$0.27M0.0%N/A0.018%Search for SEC Filing on Google Icon
1/30/2026Jennison Associates LLC288,847$7.84M0.0%N/A0.535%Search for SEC Filing on Google Icon
1/30/2026Torren Management LLC1,099$30K0.0%N/A0.002%Search for SEC Filing on Google Icon
1/29/2026Pictet Asset Management Holding SA773,148$20.99M0.0%N/A1.431%Search for SEC Filing on Google Icon
1/29/2026UBS Group AG1,806,243$49.04M0.0%+563.4%3.342%Search for SEC Filing on Google Icon
1/29/2026Vanguard Group Inc.2,388,439$64.85M0.0%-2.2%4.420%Search for SEC Filing on Google Icon
1/29/2026China Universal Asset Management Co. Ltd.8,806$0.24M0.0%N/A0.016%Search for SEC Filing on Google Icon
1/27/2026GF Fund Management CO. LTD.1,061$29K0.0%N/A0.002%Search for SEC Filing on Google Icon
1/26/2026Mirae Asset Global Investments Co. Ltd.2,626$71K0.0%N/A0.005%Search for SEC Filing on Google Icon
1/9/2026SG Americas Securities LLC5,518$0.15M0.0%N/A0.010%Search for SEC Filing on Google Icon
1/1/2026JPMorgan Chase & Co.29,947$0.56M0.0%+81.8%0.055%Search for SEC Filing on Google Icon
11/17/2025Woodline Partners LP602,252$11.33M0.1%+7.9%1.114%Search for SEC Filing on Google Icon
11/17/2025TCG Crossover Management LLC2,117,103$39.82M2.0%-24.4%3.918%Search for SEC Filing on Google Icon
11/17/2025Verition Fund Management LLC47,001$0.88M0.0%+40.3%0.087%Search for SEC Filing on Google Icon
11/17/2025Prelude Capital Management LLC15,735$0.30M0.0%N/A0.029%Search for SEC Filing on Google Icon
11/17/2025Parkman Healthcare Partners LLC843,502$15.87M1.7%+17.9%1.561%Search for SEC Filing on Google Icon
11/17/2025Millennium Management LLC40,113$0.76M0.0%N/A0.074%Search for SEC Filing on Google Icon
11/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.16,863$0.32M0.0%-11.6%0.031%Search for SEC Filing on Google Icon
11/17/2025Bank of America Corp DE55,473$1.04M0.0%+207.7%0.103%Search for SEC Filing on Google Icon
11/17/2025Boothbay Fund Management LLC61,299$1.15M0.0%N/A0.113%Search for SEC Filing on Google Icon
11/17/2025Alliancebernstein L.P.19,850$0.37M0.0%-19.2%0.037%Search for SEC Filing on Google Icon
11/14/2025Schonfeld Strategic Advisors LLC190,244$3.58M0.0%-48.0%0.352%Search for SEC Filing on Google Icon
11/14/2025SummitTX Capital L.P.112,404$2.11M0.1%N/A0.208%Search for SEC Filing on Google Icon
11/14/2025Two Sigma Investments LP10,500$0.20M0.0%N/A0.019%Search for SEC Filing on Google Icon
11/14/2025Integral Health Asset Management LLC575,000$10.82M0.7%N/A1.064%Search for SEC Filing on Google Icon
11/14/2025Wellington Management Group LLP1,125,395$21.17M0.0%-8.2%2.083%Search for SEC Filing on Google Icon
11/13/2025Marshall Wace LLP867,999$16.33M0.0%+198.8%1.606%Search for SEC Filing on Google Icon
11/13/2025UBS Group AG272,271$5.12M0.0%+16.9%0.504%Search for SEC Filing on Google Icon
11/13/2025BNP Paribas Financial Markets6,527$0.12M0.0%+110.8%0.012%Search for SEC Filing on Google Icon
11/13/2025Russell Investments Group Ltd.3,034$57K0.0%+1,963.9%0.006%Search for SEC Filing on Google Icon
11/12/2025Barclays PLC85,315$1.61M0.0%-12.0%0.158%Search for SEC Filing on Google Icon
11/12/2025Rafferty Asset Management LLC34,521$0.65M0.0%N/A0.064%Search for SEC Filing on Google Icon
11/12/2025Intech Investment Management LLC10,396$0.20M0.0%-51.2%0.019%Search for SEC Filing on Google Icon
11/10/2025Ameritas Investment Partners Inc.2,741$52K0.0%-23.0%0.005%Search for SEC Filing on Google Icon
11/7/2025Vanguard Group Inc.2,442,551$45.94M0.0%+12.5%4.531%Search for SEC Filing on Google Icon
11/7/2025JPMorgan Chase & Co.29,947$0.56M0.0%+81.8%0.056%Search for SEC Filing on Google Icon
11/6/2025Rhumbline Advisers49,406$0.93M0.0%+2.8%0.092%Search for SEC Filing on Google Icon
11/5/2025Alps Advisors Inc.25,962$0.49M0.0%-10.4%0.048%Search for SEC Filing on Google Icon
11/3/2025New York State Common Retirement Fund6,300$0.12M0.0%+34.0%0.012%Search for SEC Filing on Google Icon
8/15/2025BNP Paribas Financial Markets3,097$34K0.0%+229.8%0.006%Search for SEC Filing on Google Icon
8/15/2025Bain Capital Life Sciences Investors LLC2,439,538$26.79M3.4%+6.3%4.525%Search for SEC Filing on Google Icon
8/15/2025Bank of America Corp DE18,031$0.20M0.0%+71.2%0.033%Search for SEC Filing on Google Icon
8/14/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.19,084$0.21M0.0%+85.4%0.035%Search for SEC Filing on Google Icon
8/14/2025The Manufacturers Life Insurance Company 13,190$0.15M0.0%N/A0.024%Search for SEC Filing on Google Icon
8/13/2025Marshall Wace LLP290,526$3.19M0.0%-4.7%0.539%Search for SEC Filing on Google Icon
8/13/2025Invesco Ltd.16,300$0.18M0.0%+6.4%0.030%Search for SEC Filing on Google Icon
8/13/2025Virtus Investment Advisers LLC8,134$89K0.0%N/A0.015%Search for SEC Filing on Google Icon
8/13/2025Norges Bank969,916$10.65M0.0%N/A1.799%Search for SEC Filing on Google Icon
8/12/2025Ameritas Investment Partners Inc.3,558$39K0.0%+95.3%0.007%Search for SEC Filing on Google Icon
8/12/2025American Century Companies Inc.22,362$0.25M0.0%N/A0.041%Search for SEC Filing on Google Icon
Data available starting January 2016

See Full Table
Upstream Bio logo
Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases that focuses on severe respiratory disorders. It develops verekitug, a monoclonal antibody that targets and inhibits the thymic stromal lymphopoietin receptor. The company also develops therapies to treat severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Upstream Bio, Inc. was incorporated in 2021 and is based in Waltham, Massachusetts.
Read More on Upstream Bio

Today's Range

Now: $7.92
Low: $7.78
High: $8.27

50 Day Range

MA: $25.46
Low: $7.92
High: $32.60

52 Week Range

Now: $7.92
Low: $5.14
High: $33.68

Volume

1,538,564 shs

Average Volume

2,131,444 shs

Market Capitalization

$428.00 million

P/E Ratio

N/A

Dividend Yield

N/A

Beta

1.9

Who are the company insiders with the largest holdings of Upstream Bio?

Upstream Bio's top insider shareholders include:
  1. Erez Chimovits (Director)
  2. Ai Upstream Llc (Major Shareholder)
Learn More about top insider investors at Upstream Bio.

Who are the major institutional investors of Upstream Bio?

Upstream Bio's top institutional shareholders include:
  1. Decheng Capital LLC — 5.82%
  2. Norges Bank — 5.33%
  3. Vanguard Group Inc. — 4.42%
  4. UBS Group AG — 3.34%
  5. Janus Henderson Group PLC — 2.83%
  6. Altshuler Shaham Ltd — 2.48%
Learn More about top institutional investors of Upstream Bio stock.

Which institutional investors are selling Upstream Bio stock?

Within the previous quarter, UPB stock was sold by these institutional investors:
  1. Bain Capital Life Sciences Investors LLC
  2. Marshall Wace LLP
  3. Wellington Management Group LLP
  4. Siren L.L.C.
  5. Diadema Partners LP
  6. Decheng Capital LLC
  7. Nantahala Capital Management LLC
  8. Altshuler Shaham Ltd

Which institutional investors are buying Upstream Bio stock?

Within the last quarter, UPB stock was purchased by institutional investors including:
  1. Norges Bank
  2. UBS Group AG
  3. Janus Henderson Group PLC
  4. Pictet Asset Management Holding SA
  5. Vestal Point Capital LP
  6. Millennium Management LLC
  7. Barclays PLC
  8. Alyeska Investment Group L.P.
In the previous year, these company insiders have bought Upstream Bio stock:
  1. Erez Chimovits (Director)
  2. Ai Upstream Llc (Major Shareholder)
Learn More investors buying Upstream Bio stock.