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UPB Insider Trading

Insider Ownership Percentage: 13.56%
Insider Buying (Last 12 Months): $0.00
Insider Selling (Last 12 Months): $0.00

Upstream Bio Insider Trading History Chart

This chart shows the insider buying and selling history at Upstream Bio by year and by quarter.

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Upstream Bio Share Price & Price History

Current Price: $27.74
Price Change: ▲ Price Increase of +0.77 (2.86%)
As of 12/4/2025 05:00 PM ET

This chart shows the closing price history over time for UPB up to the past year.

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Days: 30 | 90 | 365

Upstream Bio Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
10/15/2024Ai Upstream LlcMajor ShareholderBuy1,175,000$17.00$19,975,000.001,175,000View SEC Filing Icon  
10/15/2024Erez ChimovitsDirectorBuy825,000$17.00$14,025,000.004,554,873View SEC Filing Icon  
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SEC Filings (Institutional Ownership Changes) for Upstream Bio (NASDAQ:UPB)

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at UPB by year and by quarter.

Skip Institutional Buying and Selling Chart and Table DataRead Chart Data in Institutional Trading History Table

Upstream Bio Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
11/17/2025Woodline Partners LP602,252$11.33M0.1%+7.9%1.114%Search for SEC Filing on Google Icon
11/17/2025TCG Crossover Management LLC2,117,103$39.82M2.0%-24.4%3.918%Search for SEC Filing on Google Icon
11/17/2025Verition Fund Management LLC47,001$0.88M0.0%+40.3%0.087%Search for SEC Filing on Google Icon
11/17/2025Prelude Capital Management LLC15,735$0.30M0.0%N/A0.029%Search for SEC Filing on Google Icon
11/17/2025Parkman Healthcare Partners LLC843,502$15.87M1.7%+17.9%1.561%Search for SEC Filing on Google Icon
11/17/2025Millennium Management LLC40,113$0.76M0.0%N/A0.074%Search for SEC Filing on Google Icon
11/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.16,863$0.32M0.0%-11.6%0.031%Search for SEC Filing on Google Icon
11/17/2025Bank of America Corp DE55,473$1.04M0.0%+207.7%0.103%Search for SEC Filing on Google Icon
11/17/2025Boothbay Fund Management LLC61,299$1.15M0.0%N/A0.113%Search for SEC Filing on Google Icon
11/17/2025Alliancebernstein L.P.19,850$0.37M0.0%-19.2%0.037%Search for SEC Filing on Google Icon
11/14/2025Schonfeld Strategic Advisors LLC190,244$3.58M0.0%-48.0%0.352%Search for SEC Filing on Google Icon
11/14/2025SummitTX Capital L.P.112,404$2.11M0.1%N/A0.208%Search for SEC Filing on Google Icon
11/14/2025Two Sigma Investments LP10,500$0.20M0.0%N/A0.019%Search for SEC Filing on Google Icon
11/14/2025Integral Health Asset Management LLC575,000$10.82M0.7%N/A1.064%Search for SEC Filing on Google Icon
11/14/2025Wellington Management Group LLP1,125,395$21.17M0.0%-8.2%2.083%Search for SEC Filing on Google Icon
11/13/2025Marshall Wace LLP867,999$16.33M0.0%+198.8%1.606%Search for SEC Filing on Google Icon
11/13/2025UBS Group AG272,271$5.12M0.0%+16.9%0.504%Search for SEC Filing on Google Icon
11/13/2025BNP Paribas Financial Markets6,527$0.12M0.0%+110.8%0.012%Search for SEC Filing on Google Icon
11/13/2025Russell Investments Group Ltd.3,034$57K0.0%+1,963.9%0.006%Search for SEC Filing on Google Icon
11/12/2025Barclays PLC85,315$1.61M0.0%-12.0%0.158%Search for SEC Filing on Google Icon
11/12/2025Rafferty Asset Management LLC34,521$0.65M0.0%N/A0.064%Search for SEC Filing on Google Icon
11/12/2025Intech Investment Management LLC10,396$0.20M0.0%-51.2%0.019%Search for SEC Filing on Google Icon
11/10/2025Ameritas Investment Partners Inc.2,741$52K0.0%-23.0%0.005%Search for SEC Filing on Google Icon
11/7/2025Vanguard Group Inc.2,442,551$45.94M0.0%+12.5%4.531%Search for SEC Filing on Google Icon
11/7/2025JPMorgan Chase & Co.29,947$0.56M0.0%+81.8%0.056%Search for SEC Filing on Google Icon
11/6/2025Rhumbline Advisers49,406$0.93M0.0%+2.8%0.092%Search for SEC Filing on Google Icon
11/5/2025Alps Advisors Inc.25,962$0.49M0.0%-10.4%0.048%Search for SEC Filing on Google Icon
11/3/2025New York State Common Retirement Fund6,300$0.12M0.0%+34.0%0.012%Search for SEC Filing on Google Icon
8/15/2025BNP Paribas Financial Markets3,097$34K0.0%+229.8%0.006%Search for SEC Filing on Google Icon
8/15/2025Bain Capital Life Sciences Investors LLC2,439,538$26.79M3.4%+6.3%4.525%Search for SEC Filing on Google Icon
8/15/2025Bank of America Corp DE18,031$0.20M0.0%+71.2%0.033%Search for SEC Filing on Google Icon
8/14/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.19,084$0.21M0.0%+85.4%0.035%Search for SEC Filing on Google Icon
8/14/2025The Manufacturers Life Insurance Company 13,190$0.15M0.0%N/A0.024%Search for SEC Filing on Google Icon
8/13/2025Marshall Wace LLP290,526$3.19M0.0%-4.7%0.539%Search for SEC Filing on Google Icon
8/13/2025Invesco Ltd.16,300$0.18M0.0%+6.4%0.030%Search for SEC Filing on Google Icon
8/13/2025Virtus Investment Advisers LLC8,134$89K0.0%N/A0.015%Search for SEC Filing on Google Icon
8/13/2025Norges Bank969,916$10.65M0.0%N/A1.799%Search for SEC Filing on Google Icon
8/12/2025Ameritas Investment Partners Inc.3,558$39K0.0%+95.3%0.007%Search for SEC Filing on Google Icon
8/12/2025American Century Companies Inc.22,362$0.25M0.0%N/A0.041%Search for SEC Filing on Google Icon
8/12/2025Rhumbline Advisers48,066$0.53M0.0%+260.7%0.089%Search for SEC Filing on Google Icon
8/12/2025Legal & General Group Plc3,174$35K0.0%+83.0%0.006%Search for SEC Filing on Google Icon
8/12/2025JPMorgan Chase & Co.16,469$0.18M0.0%+8.4%0.031%Search for SEC Filing on Google Icon
8/8/2025Intech Investment Management LLC21,290$0.23M0.0%+39.3%0.040%Search for SEC Filing on Google Icon
8/8/2025Creative Planning14,030$0.15M0.0%N/A0.026%Search for SEC Filing on Google Icon
8/8/2025Police & Firemen s Retirement System of New Jersey7,833$86K0.0%+133.8%0.015%Search for SEC Filing on Google Icon
8/8/2025Geode Capital Management LLC646,635$7.10M0.0%+57.5%1.202%Search for SEC Filing on Google Icon
7/25/2025CWM LLC3,312$36K0.0%+107.5%0.006%Search for SEC Filing on Google Icon
6/27/2025Goldman Sachs Group Inc.32,955$0.20M0.0%-25.9%0.061%Search for SEC Filing on Google Icon
5/29/2025Rhumbline Advisers13,327$82K0.0%-20.3%0.025%Search for SEC Filing on Google Icon
5/23/2025Siren L.L.C.788,450$4.83M0.3%-1.4%1.466%Search for SEC Filing on Google Icon
5/16/2025Woodline Partners LP557,063$3.41M0.0%+5.8%1.036%Search for SEC Filing on Google Icon
5/16/2025Goldman Sachs Group Inc.32,955$0.20M0.0%-25.9%0.061%Search for SEC Filing on Google Icon
5/16/2025Parkman Healthcare Partners LLC233,563$1.43M0.2%N/A0.434%Search for SEC Filing on Google Icon
5/16/2025AQR Capital Management LLC18,822$0.12M0.0%N/A0.035%Search for SEC Filing on Google Icon
5/16/2025ADAR1 Capital Management LLC15,000$92K0.0%N/A0.028%Search for SEC Filing on Google Icon
5/15/2025Nantahala Capital Management LLC594,971$3.64M0.1%-0.8%1.106%Search for SEC Filing on Google Icon
5/15/2025Velan Capital Investment Management LP107,000$0.66M0.7%N/A0.199%Search for SEC Filing on Google Icon
5/15/2025Siren L.L.C.788,450$4.83M0.3%-1.4%1.466%Search for SEC Filing on Google Icon
5/14/2025Wellington Management Group LLP1,313,457$8.03M0.0%-17.0%2.442%Search for SEC Filing on Google Icon
5/12/2025Nuveen LLC22,586$0.14M0.0%N/A0.042%Search for SEC Filing on Google Icon
5/9/2025Charles Schwab Investment Management Inc.132,173$0.81M0.0%-2.3%0.246%Search for SEC Filing on Google Icon
5/8/2025XTX Topco Ltd12,731$78K0.0%N/A0.024%Search for SEC Filing on Google Icon
5/1/2025New York State Common Retirement Fund4,700$29K0.0%N/A0.009%Search for SEC Filing on Google Icon
4/30/2025Alps Advisors Inc.39,079$0.24M0.0%-9.8%0.073%Search for SEC Filing on Google Icon
4/8/2025Rhumbline Advisers13,327$82K0.0%-20.3%0.025%Search for SEC Filing on Google Icon
3/24/2025Wellington Management Group LLP1,583,154$25.63M0.0%N/A2.951%Search for SEC Filing on Google Icon
2/17/2025VR Adviser LLC2,295,319$37.74M2.6%N/A4.282%Search for SEC Filing on Google Icon
2/17/2025Woodline Partners LP526,511$8.66M0.1%N/A0.982%Search for SEC Filing on Google Icon
2/17/2025Sandia Investment Management LP10,000$0.16M0.4%N/A0.019%Search for SEC Filing on Google Icon
2/17/2025Nuveen Asset Management LLC22,586$0.37M0.0%N/A0.042%Search for SEC Filing on Google Icon
2/17/2025Orbimed Advisors LLC5,693,589$93.60M2.1%N/A10.622%Search for SEC Filing on Google Icon
2/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.9,828$0.16M0.0%N/A0.018%Search for SEC Filing on Google Icon
2/17/2025Enavate Sciences GP LLC2,459,703$40.44M29.0%N/A4.589%Search for SEC Filing on Google Icon
2/17/2025Deutsche Bank AG14,851$0.24M0.0%N/A0.028%Search for SEC Filing on Google Icon
2/17/2025Deep Track Capital LP1,000,000$16.44M0.6%N/A1.866%Search for SEC Filing on Google Icon
2/17/2025Balyasny Asset Management L.P.301,152$4.95M0.0%N/A0.562%Search for SEC Filing on Google Icon
2/17/2025Bank of America Corp DE13,963$0.23M0.0%N/A0.026%Search for SEC Filing on Google Icon
2/17/2025BNP Paribas Financial Markets1,511$25K0.0%N/A0.003%Search for SEC Filing on Google Icon
2/17/2025Alyeska Investment Group L.P.85,000$1.40M0.0%N/A0.159%Search for SEC Filing on Google Icon
2/14/2025Jane Street Group LLC45,549$0.75M0.0%N/A0.085%Search for SEC Filing on Google Icon
2/14/2025Samsara BioCapital LLC2,217,146$36.45M4.9%N/A4.136%Search for SEC Filing on Google Icon
2/14/2025Soros Fund Management LLC46,350$0.76M0.0%N/A0.086%Search for SEC Filing on Google Icon
2/14/2025TCG Crossover Management LLC2,801,763$44.86M4.4%N/A5.227%Search for SEC Filing on Google Icon
2/14/2025Nantahala Capital Management LLC600,000$9.86M0.4%N/A1.119%Search for SEC Filing on Google Icon
2/14/2025Northern Trust Corp143,721$2.36M0.0%N/A0.268%Search for SEC Filing on Google Icon
2/14/2025Lynx1 Capital Management LP240,042$3.95M1.5%N/A0.448%Search for SEC Filing on Google Icon
2/14/2025Decheng Capital LLC3,285,293$54.01M11.6%N/A6.129%Search for SEC Filing on Google Icon
2/14/2025Bain Capital Life Sciences Investors LLC2,295,322$37.74M4.4%N/A4.282%Search for SEC Filing on Google Icon
2/14/2025Tower Research Capital LLC TRC2,846$47K0.0%N/A0.005%Search for SEC Filing on Google Icon
2/14/2025MetLife Investment Management LLC11,034$0.18M0.0%N/A0.021%Search for SEC Filing on Google Icon
2/13/2025Marshall Wace LLP290,734$4.78M0.0%N/A0.542%Search for SEC Filing on Google Icon
2/13/2025Walleye Capital LLC10,000$0.16M0.0%N/A0.019%Search for SEC Filing on Google Icon
2/13/2025Barclays PLC27,017$0.45M0.0%N/A0.050%Search for SEC Filing on Google Icon
2/13/2025Summit Investment Advisors Inc.1,822$30K0.0%N/A0.003%Search for SEC Filing on Google Icon
2/13/2025Legal & General Group Plc1,734$28K0.0%N/A0.003%Search for SEC Filing on Google Icon
2/13/2025Invesco Ltd.15,602$0.26M0.0%N/A0.029%Search for SEC Filing on Google Icon
2/13/2025FMR LLC7,176,187$117.98M0.0%N/A13.388%Search for SEC Filing on Google Icon
2/13/2025Wells Fargo & Company MN9,047$0.15M0.0%N/A0.017%Search for SEC Filing on Google Icon
2/12/2025Geode Capital Management LLC363,269$5.97M0.0%N/A0.678%Search for SEC Filing on Google Icon
2/12/2025Alliancebernstein L.P.1,111,337$18.27M0.0%N/A2.073%Search for SEC Filing on Google Icon
Data available starting January 2016

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Upstream Bio logo
Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases that focuses on severe respiratory disorders. It develops verekitug, a monoclonal antibody that targets and inhibits the thymic stromal lymphopoietin receptor. The company also develops therapies to treat severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Upstream Bio, Inc. was incorporated in 2021 and is based in Waltham, Massachusetts.
Read More on Upstream Bio

Today's Range

Now: $27.74
Low: $26.69
High: $28.45

50 Day Range

MA: $23.19
Low: $17.26
High: $28.98

52 Week Range

Now: $27.74
Low: $5.14
High: $33.00

Volume

568,481 shs

Average Volume

482,285 shs

Market Capitalization

$1.50 billion

P/E Ratio

N/A

Dividend Yield

N/A

Beta

1.83

Who are the company insiders with the largest holdings of Upstream Bio?

Upstream Bio's top insider shareholders include:
  1. Erez Chimovits (Director)
  2. Ai Upstream Llc (Major Shareholder)
Learn More about top insider investors at Upstream Bio.

Who are the major institutional investors of Upstream Bio?

Upstream Bio's top institutional shareholders include:
  1. Vanguard Group Inc. — 4.53%
  2. TCG Crossover Management LLC — 3.92%
  3. Wellington Management Group LLP — 2.08%
  4. Marshall Wace LLP — 1.61%
  5. Parkman Healthcare Partners LLC — 1.56%
  6. Woodline Partners LP — 1.11%
Learn More about top institutional investors of Upstream Bio stock.

Which institutional investors are selling Upstream Bio stock?

Within the previous quarter, UPB stock was sold by these institutional investors:
  1. TCG Crossover Management LLC
  2. Schonfeld Strategic Advisors LLC
  3. Wellington Management Group LLP
  4. Barclays PLC
  5. Intech Investment Management LLC
  6. Alliancebernstein L.P.
  7. Alps Advisors Inc.
  8. MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

Which institutional investors are buying Upstream Bio stock?

Within the last quarter, UPB stock was purchased by institutional investors including:
  1. Marshall Wace LLP
  2. Integral Health Asset Management LLC
  3. Vanguard Group Inc.
  4. Parkman Healthcare Partners LLC
  5. SummitTX Capital L.P.
  6. Boothbay Fund Management LLC
  7. Woodline Partners LP
  8. Millennium Management LLC
In the previous year, these company insiders have bought Upstream Bio stock:
  1. Erez Chimovits (Director)
  2. Ai Upstream Llc (Major Shareholder)
Learn More investors buying Upstream Bio stock.