| 11/17/2025 | Armistice Capital LLC | 2,096,000 | $18.51M | 0.3% | -1.9% | 3.139% |  |
| 11/17/2025 | Woodline Partners LP | 307,554 | $2.72M | 0.0% | N/A | 0.461% |  |
| 11/17/2025 | Vivo Capital LLC | 2,644,985 | $23.36M | 1.9% | +71.9% | 3.961% |  |
| 11/17/2025 | Verition Fund Management LLC | 141,832 | $1.25M | 0.0% | N/A | 0.212% |  |
| 11/17/2025 | Susquehanna Fundamental Investments LLC | 63,411 | $0.56M | 0.0% | -31.7% | 0.095% |  |
| 11/17/2025 | Polar Capital Holdings Plc | 1,058,776 | $9.35M | 0.0% | +5.9% | 1.586% |  |
| 11/17/2025 | Polymer Capital Management HK LTD | 309,780 | $2.74M | 0.4% | N/A | 0.464% |  |
| 11/17/2025 | Nantahala Capital Management LLC | 1,292,903 | $11.42M | 0.4% | -56.2% | 1.936% |  |
| 11/17/2025 | Millennium Management LLC | 1,159,598 | $10.24M | 0.0% | +2,072.1% | 1.737% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,556 | $0.23M | 0.0% | -14.7% | 0.038% |  |
| 11/17/2025 | Foresite Capital Management VI LLC | 2,615,120 | $23.09M | 8.9% | +104.9% | 3.916% |  |
| 11/17/2025 | Bank of America Corp DE | 149,782 | $1.32M | 0.0% | -49.2% | 0.224% |  |
| 11/17/2025 | Alliancebernstein L.P. | 67,270 | $0.59M | 0.0% | -25.6% | 0.101% |  |
| 11/14/2025 | Raymond James Financial Inc. | 199,266 | $1.76M | 0.0% | +8,892.1% | 0.298% |  |
| 11/14/2025 | Orbimed Advisors LLC | 887,561 | $7.84M | 0.2% | N/A | 1.329% |  |
| 11/14/2025 | Acuta Capital Partners LLC | 143,446 | $1.27M | 1.3% | -4.6% | 0.215% |  |
| 11/14/2025 | Balyasny Asset Management L.P. | 4,146,762 | $36.62M | 0.0% | -1.4% | 6.210% |  |
| 11/14/2025 | Two Sigma Investments LP | 424,252 | $3.75M | 0.0% | -27.7% | 0.635% |  |
| 11/14/2025 | Squarepoint Ops LLC | 144,355 | $1.28M | 0.0% | -58.9% | 0.216% |  |
| 11/14/2025 | Arrowpoint Investment Partners Singapore Pte. Ltd. | 29,087 | $0.26M | 0.3% | N/A | 0.044% |  |
| 11/13/2025 | Marshall Wace LLP | 1,055,389 | $9.32M | 0.0% | +293.3% | 1.580% |  |
| 11/13/2025 | UBS Group AG | 284,402 | $2.51M | 0.0% | -29.1% | 0.426% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 8,550 | $75K | 0.0% | +110.9% | 0.013% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 4,578 | $40K | 0.0% | +182.9% | 0.007% |  |
| 11/13/2025 | Jefferies Financial Group Inc. | 590,184 | $5.21M | 0.0% | +48.4% | 0.884% |  |
| 11/12/2025 | Barclays PLC | 168,375 | $1.49M | 0.0% | -13.0% | 0.252% |  |
| 11/12/2025 | Rafferty Asset Management LLC | 91,852 | $0.81M | 0.0% | -12.4% | 0.138% |  |
| 11/12/2025 | Intech Investment Management LLC | 19,800 | $0.18M | 0.0% | -28.9% | 0.030% |  |
| 11/10/2025 | TD Asset Management Inc | 74,000 | $0.65M | 0.0% | N/A | 0.111% |  |
| 11/10/2025 | Aries Wealth Management | 26,249 | $0.23M | 0.1% | +10.5% | 0.039% |  |
| 11/7/2025 | Vanguard Group Inc. | 3,479,011 | $30.72M | 0.0% | +1.6% | 5.210% |  |
| 11/6/2025 | Rhumbline Advisers | 57,994 | $0.51M | 0.0% | -2.6% | 0.094% |  |
| 11/6/2025 | Profund Advisors LLC | 19,778 | $0.18M | 0.0% | -8.9% | 0.032% |  |
| 10/31/2025 | Y Intercept Hong Kong Ltd | 14,298 | $0.13M | 0.0% | -90.8% | 0.023% |  |
| 10/23/2025 | SG Americas Securities LLC | 11,367 | $100K | 0.0% | -10.4% | 0.018% |  |
| 8/27/2025 | Squarepoint Ops LLC | 351,569 | $1.46M | 0.0% | +2,995.6% | 0.571% |  |
| 8/18/2025 | Nomura Holdings Inc. | 674,596 | $2.80M | 0.0% | +224.2% | 1.096% |  |
| 8/15/2025 | Exome Asset Management LLC | 599,900 | $2.49M | 1.3% | N/A | 0.975% |  |
| 8/15/2025 | E Fund Management Co. Ltd. | 11,700 | $49K | 0.0% | N/A | 0.019% |  |
| 8/15/2025 | Rafferty Asset Management LLC | 104,850 | $0.44M | 0.0% | N/A | 0.170% |  |
| 8/15/2025 | Rosalind Advisors Inc. | 2,043,563 | $8.48M | 3.8% | -22.7% | 3.321% |  |
| 8/15/2025 | Engineers Gate Manager LP | 87,107 | $0.36M | 0.0% | N/A | 0.142% |  |
| 8/15/2025 | BVF Inc. IL | 3,404,425 | $14.13M | 0.5% | +62.1% | 5.532% |  |
| 8/15/2025 | Balyasny Asset Management L.P. | 4,205,968 | $17.46M | 0.0% | -12.2% | 6.835% |  |
| 8/15/2025 | Bank of America Corp DE | 294,961 | $1.22M | 0.0% | +365.6% | 0.479% |  |
| 8/14/2025 | Nantahala Capital Management LLC | 2,954,735 | $12.26M | 0.5% | +28.5% | 4.801% |  |
| 8/14/2025 | Acuta Capital Partners LLC | 150,414 | $0.62M | 0.9% | -14.5% | 0.244% |  |
| 8/14/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,945 | $0.12M | 0.0% | +28.8% | 0.049% |  |
| 8/14/2025 | Armistice Capital LLC | 2,136,000 | $8.86M | 0.2% | N/A | 3.471% |  |
| 8/14/2025 | The Manufacturers Life Insurance Company | 16,188 | $67K | 0.0% | +9.8% | 0.026% |  |
| 8/14/2025 | Squarepoint Ops LLC | 351,569 | $1.46M | 0.0% | +2,995.6% | 0.571% |  |
| 8/14/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 255,253 | $1.06M | 0.1% | -51.1% | 0.415% |  |
| 8/14/2025 | Nebula Research & Development LLC | 12,689 | $53K | 0.0% | N/A | 0.021% |  |
| 8/14/2025 | Qube Research & Technologies Ltd | 282,228 | $1.17M | 0.0% | N/A | 0.459% |  |
| 8/13/2025 | Marshall Wace LLP | 268,333 | $1.11M | 0.0% | -87.9% | 0.436% |  |
| 8/13/2025 | Kennedy Capital Management LLC | 90,203 | $0.37M | 0.0% | +231.3% | 0.147% |  |
| 8/13/2025 | Invesco Ltd. | 52,063 | $0.22M | 0.0% | +40.0% | 0.085% |  |
| 8/13/2025 | Panagora Asset Management Inc. | 132,444 | $0.55M | 0.0% | N/A | 0.215% |  |
| 8/12/2025 | Foresite Capital Management VI LLC | 1,276,520 | $5.30M | 3.0% | N/A | 2.074% |  |
| 8/12/2025 | XTX Topco Ltd | 188,162 | $0.78M | 0.0% | N/A | 0.306% |  |
| 8/12/2025 | Jefferies Financial Group Inc. | 397,755 | $1.65M | 0.0% | +47.0% | 0.646% |  |
| 8/12/2025 | Rhumbline Advisers | 59,553 | $0.25M | 0.0% | +19.2% | 0.097% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 21,834 | $91K | 0.0% | -13.6% | 0.035% |  |
| 8/8/2025 | Intech Investment Management LLC | 27,833 | $0.12M | 0.0% | +35.9% | 0.051% |  |
| 8/8/2025 | Geode Capital Management LLC | 1,199,259 | $4.98M | 0.0% | +24.9% | 2.182% |  |
| 8/7/2025 | Profund Advisors LLC | 21,708 | $90K | 0.0% | N/A | 0.040% |  |
| 8/7/2025 | Los Angeles Capital Management LLC | 25,428 | $0.11M | 0.0% | N/A | 0.046% |  |
| 8/1/2025 | Y Intercept Hong Kong Ltd | 154,917 | $0.64M | 0.0% | N/A | 0.282% |  |
| 7/29/2025 | AIGH Capital Management LLC | 2,003,179 | $8.31M | 3.7% | -14.3% | 3.645% |  |
| 7/28/2025 | Aries Wealth Management | 23,749 | $99K | 0.0% | -10.1% | 0.043% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 756,402 | $4.56M | 0.0% | +236.9% | 1.377% |  |
| 5/29/2025 | Rhumbline Advisers | 49,959 | $0.30M | 0.0% | +32.8% | 0.091% |  |
| 5/16/2025 | Woodline Partners LP | 78,676 | $0.47M | 0.0% | -89.1% | 0.153% |  |
| 5/16/2025 | Octagon Capital Advisors LP | 1,720,000 | $10.37M | 1.1% | N/A | 3.340% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 756,402 | $4.56M | 0.0% | +236.9% | 1.469% |  |
| 5/16/2025 | Polar Asset Management Partners Inc. | 49,800 | $0.30M | 0.0% | N/A | 0.097% |  |
| 5/16/2025 | AQR Capital Management LLC | 62,603 | $0.38M | 0.0% | +78.2% | 0.122% |  |
| 5/15/2025 | Nantahala Capital Management LLC | 2,298,541 | $13.86M | 0.6% | -38.7% | 4.464% |  |
| 5/15/2025 | Royal Bank of Canada | 95,655 | $0.58M | 0.0% | -64.7% | 0.186% |  |
| 5/15/2025 | Nomura Holdings Inc. | 208,105 | $1.26M | 0.0% | N/A | 0.404% |  |
| 5/14/2025 | MetLife Investment Management LLC | 22,025 | $0.13M | 0.0% | -14.2% | 0.043% |  |
| 5/14/2025 | Stonepine Capital Management LLC | 613,000 | $3.70M | 3.5% | -29.5% | 1.191% |  |
| 5/14/2025 | Wellington Management Group LLP | 162,064 | $0.98M | 0.0% | N/A | 0.315% |  |
| 5/12/2025 | Nuveen LLC | 50,633 | $0.31M | 0.0% | N/A | 0.098% |  |
| 5/12/2025 | Invesco Ltd. | 37,184 | $0.22M | 0.0% | +153.3% | 0.072% |  |
| 5/9/2025 | Deutsche Bank AG | 39,079 | $0.24M | 0.0% | +61.9% | 0.076% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 117,784 | $0.71M | 0.0% | +3.7% | 0.229% |  |
| 5/8/2025 | Jefferies Financial Group Inc. | 270,520 | $1.63M | 0.0% | N/A | 0.525% |  |
| 5/6/2025 | AIGH Capital Management LLC | 2,337,754 | $14.10M | 5.8% | -12.3% | 4.540% |  |
| 4/8/2025 | Rhumbline Advisers | 49,959 | $0.30M | 0.0% | +32.8% | 0.097% |  |
| 2/17/2025 | Woodline Partners LP | 723,806 | $3.74M | 0.0% | N/A | 1.626% |  |
| 2/17/2025 | Soleus Capital Management L.P. | 2,184,026 | $11.29M | 0.7% | -22.8% | 4.907% |  |
| 2/17/2025 | Squarepoint Ops LLC | 17,865 | $92K | 0.0% | N/A | 0.040% |  |
| 2/17/2025 | Two Sigma Advisers LP | 60,017 | $0.31M | 0.0% | +41.2% | 0.135% |  |
| 2/17/2025 | Two Sigma Investments LP | 81,458 | $0.42M | 0.0% | -19.0% | 0.183% |  |
| 2/17/2025 | Stonepine Capital Management LLC | 870,000 | $4.50M | 3.6% | -33.6% | 1.955% |  |
| 2/17/2025 | Sherbrooke Park Advisers LLC | 11,741 | $61K | 0.0% | N/A | 0.026% |  |
| 2/17/2025 | ProShare Advisors LLC | 10,925 | $56K | 0.0% | N/A | 0.025% |  |
| 2/17/2025 | Nuveen Asset Management LLC | 50,633 | $0.26M | 0.0% | +47.2% | 0.114% |  |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 608,524 | $3.15M | 0.2% | +41.3% | 1.367% |  |