| 11/17/2025 | Woodline Partners LP | 27,363 | $1.33M | 0.0% | N/A | 0.399% |  |
| 11/17/2025 | Sarissa Capital Management LP | 25,399 | $1.24M | 0.7% | -95.0% | 0.371% |  |
| 11/17/2025 | Scientech Research LLC | 6,097 | $0.30M | 0.1% | -98.5% | 0.089% |  |
| 11/17/2025 | Polymer Capital Management HK LTD | 21,248 | $1.04M | 0.1% | N/A | 0.310% |  |
| 11/17/2025 | RA Capital Management L.P. | 1,982,301 | $96.58M | 1.2% | -95.0% | 28.939% |  |
| 11/17/2025 | Millennium Management LLC | 24,764 | $1.21M | 0.0% | -122.5% | 0.362% |  |
| 11/17/2025 | Fcpm Iii Services B.V. | 379,640 | $18.50M | 3.7% | N/A | 5.542% |  |
| 11/17/2025 | Bollard Group LLC | 2,777 | $0.14M | 0.0% | -95.0% | 0.041% |  |
| 11/17/2025 | Bank of America Corp DE | 4,754 | $0.23M | 0.0% | +679.3% | 0.069% |  |
| 11/14/2025 | Virtu Financial LLC | 8,104 | $0.40M | 0.0% | -97.1% | 0.118% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 6,250 | $0.30M | 0.0% | N/A | 0.091% |  |
| 11/14/2025 | Squarepoint Ops LLC | 4,729 | $0.23M | 0.0% | N/A | 0.069% |  |
| 11/13/2025 | UBS Group AG | 75,909 | $3.70M | 0.0% | -95.0% | 1.108% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 6,075 | $0.30M | 0.0% | +497.3% | 0.089% |  |
| 11/7/2025 | Vanguard Group Inc. | 105,190 | $5.13M | 0.0% | -94.5% | 1.536% |  |
| 10/21/2025 | Ariose Capital Management Ltd | 110,173 | $5.37M | 1.8% | N/A | 1.608% |  |
| 8/12/2025 | XTX Topco Ltd | 40,943 | $66K | 0.0% | N/A | 0.032% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 84,945 | $61K | 0.0% | +218.2% | 0.068% |  |
| 5/19/2025 | Jane Street Group LLC | 194,756 | $0.14M | 0.0% | N/A | 0.156% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 84,945 | $61K | 0.0% | +218.2% | 0.068% |  |
| 5/15/2025 | OMERS ADMINISTRATION Corp | 139,600 | $100K | 0.0% | N/A | 0.112% |  |
| 4/24/2025 | Money Concepts Capital Corp | 51,535 | $37K | 0.0% | +106.1% | 0.041% |  |
| 4/17/2025 | Exchange Traded Concepts LLC | 148,073 | $0.11M | 0.0% | -10.7% | 0.119% |  |
| 2/17/2025 | Two Sigma Advisers LP | 27,500 | $31K | 0.0% | -45.3% | 0.040% |  |
| 2/17/2025 | Two Sigma Investments LP | 163,064 | $0.18M | 0.0% | +18.9% | 0.237% |  |
| 2/17/2025 | Trustees of Columbia University in the City of New York | 91,910 | $0.10M | 0.0% | N/A | 0.134% |  |
| 2/17/2025 | Millennium Management LLC | 261,837 | $0.29M | 0.0% | -13.8% | 0.381% |  |
| 2/14/2025 | RA Capital Management L.P. | 39,646,039 | $44.01M | 0.6% | +74.3% | 57.734% |  |
| 2/14/2025 | Northern Trust Corp | 157,617 | $0.18M | 0.0% | +39.0% | 0.230% |  |
| 2/14/2025 | Lynx1 Capital Management LP | 637,218 | $0.71M | 0.3% | N/A | 0.928% |  |
| 2/13/2025 | Marshall Wace LLP | 37,190 | $41K | 0.0% | -68.1% | 0.054% |  |
| 2/13/2025 | GABELLI & Co INVESTMENT ADVISERS INC. | 30,000 | $33K | 0.0% | N/A | 0.044% |  |
| 2/13/2025 | XTX Topco Ltd | 71,788 | $80K | 0.0% | N/A | 0.105% |  |
| 2/13/2025 | Renaissance Technologies LLC | 529,500 | $0.59M | 0.0% | -30.0% | 0.771% |  |
| 2/11/2025 | Virtu Financial LLC | 54,470 | $60K | 0.0% | N/A | 0.079% |  |
| 10/30/2024 | Rosalind Advisors Inc. | 76,685 | $54K | 0.0% | N/A | 0.112% |  |
| 10/10/2024 | Exchange Traded Concepts LLC | 165,805 | $0.12M | 0.0% | +40.8% | 0.242% |  |
| 9/16/2024 | Cubist Systematic Strategies LLC | 52,914 | $53K | 0.0% | N/A | 0.078% |  |
| 9/16/2024 | Point72 Asia Singapore Pte. Ltd. | 63,262 | $63K | 0.0% | N/A | 0.093% |  |
| 8/15/2024 | Point72 Asia Singapore Pte. Ltd. | 63,262 | $63K | 0.0% | N/A | 0.093% |  |
| 8/14/2024 | Cubist Systematic Strategies LLC | 52,914 | $53K | 0.0% | N/A | 0.078% |  |
| 8/12/2024 | Hsbc Holdings PLC | 49,038 | $51K | 0.0% | +177.0% | 0.072% |  |
| 8/9/2024 | Renaissance Technologies LLC | 495,300 | $0.50M | 0.0% | +48.0% | 0.726% |  |
| 8/6/2024 | Acadian Asset Management LLC | 81,305 | $79K | 0.0% | +51.4% | 0.119% |  |
| 5/17/2024 | Artal Group S.A. | 1,000,000 | $2.37M | 0.1% | -57.4% | 1.465% |  |
| 5/10/2024 | Acadian Asset Management LLC | 53,708 | $0.13M | 0.0% | N/A | 0.079% |  |
| 5/10/2024 | Vanguard Group Inc. | 1,812,899 | $4.30M | 0.0% | +4.0% | 2.657% |  |
| 5/7/2024 | SG Americas Securities LLC | 13,182 | $31K | 0.0% | -38.1% | 0.019% |  |
| 1/5/2024 | Exchange Traded Concepts LLC | 60,170 | $0.14M | 0.0% | +34.0% | 0.089% |  |
| 11/13/2023 | FMR LLC | 7,651,176 | $16.22M | 0.0% | -0.5% | 11.283% |  |
| 10/26/2023 | Chicago Partners Investment Group LLC | 17,996 | $37K | 0.0% | -28.2% | 0.027% |  |
| 10/18/2023 | Exchange Traded Concepts LLC | 44,912 | $95K | 0.0% | +63.0% | 0.066% |  |
| 10/13/2023 | SG Americas Securities LLC | 17,258 | $37K | 0.0% | N/A | 0.026% |  |
| 9/8/2023 | Tucker Asset Management LLC | 19,453 | $60K | 0.0% | N/A | 0.029% |  |
| 8/11/2023 | Artal Group S.A. | 2,688,015 | $8.31M | 0.3% | -3.8% | 4.014% |  |
| 8/4/2023 | American International Group Inc. | 18,134 | $56K | 0.0% | N/A | 0.027% |  |
| 7/27/2023 | Virtu Financial LLC | 11,765 | $36K | 0.0% | -24.4% | 0.018% |  |
| 7/20/2023 | Bourgeon Capital Management LLC | 22,450 | $69K | 0.0% | +21.7% | 0.034% |  |
| 7/20/2023 | Exchange Traded Concepts LLC | 27,547 | $85K | 0.0% | N/A | 0.041% |  |
| 5/16/2023 | Baker BROS. Advisors LP | 633,848 | $3.41M | 0.0% | -56.8% | 0.947% |  |
| 5/3/2023 | Jump Financial LLC | 10,329 | $56K | 0.0% | N/A | 0.015% |  |
| 5/1/2023 | Virtu Financial LLC | 15,562 | $84K | 0.0% | N/A | 0.023% |  |
| 4/26/2023 | Chicago Partners Investment Group LLC | 27,351 | $0.13M | 0.0% | +150.7% | 0.041% |  |
| 4/21/2023 | Denali Advisors LLC | 6,500 | $35K | 0.0% | N/A | 0.010% |  |
| 4/20/2023 | Grimes & Company Inc. | 13,622 | $73K | 0.0% | +25.5% | 0.020% |  |
| 4/17/2023 | Bourgeon Capital Management LLC | 18,450 | $99K | 0.0% | +64.7% | 0.028% |  |
| 2/14/2023 | AWM Investment Company Inc. | 100,000 | $0.67M | 0.1% | N/A | 0.259% |  |
| 2/14/2023 | RA Capital Management L.P. | 22,748,880 | $151.28M | 3.1% | +104.6% | 58.828% |  |
| 2/14/2023 | 683 Capital Management LLC | 25,419 | $0.17M | 0.0% | N/A | 0.066% |  |
| 2/13/2023 | Artal Group S.A. | 2,875,581 | $19.12M | 1.1% | +422.8% | 7.436% |  |
| 2/9/2023 | Chicago Partners Investment Group LLC | 10,911 | $63K | 0.0% | -25.0% | 0.028% |  |
| 2/8/2023 | Thrivent Financial for Lutherans | 306,811 | $2.04M | 0.0% | +1.5% | 0.793% |  |
| 1/25/2023 | Grimes & Company Inc. | 10,856 | $72K | 0.0% | N/A | 0.028% |  |
| 11/15/2022 | Ensign Peak Advisors Inc | 209,500 | $0.83M | 0.0% | N/A | 0.542% |  |
| 11/14/2022 | Ergoteles LLC | 65,332 | $0.26M | 0.0% | -24.4% | 0.172% |  |
| 11/10/2022 | Tower Research Capital LLC TRC | 46,660 | $0.19M | 0.0% | +116.9% | 0.123% |  |
| 10/27/2022 | Bourgeon Capital Management LLC | 10,700 | $43K | 0.0% | +39.0% | 0.028% |  |
| 8/16/2022 | Corton Capital Inc. | 14,856 | $74K | 0.1% | +37.6% | 0.039% |  |
| 8/16/2022 | Delphia USA Inc. | 16,132 | $80K | 0.1% | N/A | 0.042% |  |
| 5/16/2022 | Paradigm Biocapital Advisors LP | 894,404 | $5.40M | 1.4% | +42.1% | 2.384% |  |
| 5/9/2022 | Qube Research & Technologies Ltd | 37,439 | $0.23M | 0.0% | -14.6% | 0.100% |  |
| 5/3/2022 | Bourgeon Capital Management LLC | 7,700 | $47K | 0.0% | -27.4% | 0.021% |  |
| 2/15/2022 | Laurion Capital Management LP | 857,308 | $9.96M | 0.1% | +30.4% | 2.299% |  |
| 2/14/2022 | Virtus ETF Advisers LLC | 13,311 | $0.16M | 0.1% | +39.6% | 0.036% |  |
| 2/11/2022 | Ensign Peak Advisors Inc | 40,426 | $0.47M | 0.0% | N/A | 0.108% |  |
| 2/11/2022 | Parkwood LLC | 39,372 | $0.46M | 0.1% | -20.2% | 0.106% |  |
| 2/10/2022 | Qube Research & Technologies Ltd | 43,819 | $0.51M | 0.0% | +212.9% | 0.118% |  |
| 2/3/2022 | OUP Management Co. LLC | 374,714 | $4.35M | 2.0% | N/A | 1.005% |  |
| 2/3/2022 | 5AM Venture Management LLC | 6,361,723 | $73.92M | 13.9% | -4.9% | 17.060% |  |
| 2/2/2022 | New York State Common Retirement Fund | 10,649 | $0.12M | 0.0% | +36.4% | 0.029% |  |
| 2/1/2022 | Qube Research & Technologies Ltd | 43,819 | $0.51M | 0.0% | +212.9% | 0.118% |  |
| 1/31/2022 | Bourgeon Capital Management LLC | 10,600 | $0.12M | 0.0% | +75.1% | 0.028% |  |
| 11/16/2021 | Thrivent Financial for Lutherans | 303,798 | $4.76M | 0.0% | +9.1% | 0.818% |  |
| 11/16/2021 | Laurion Capital Management LP | 657,308 | $10.31M | 0.0% | +12.2% | 1.770% |  |
| 11/16/2021 | Metropolitan Life Insurance Co NY | 6,255 | $98K | 0.0% | N/A | 0.017% |  |
| 11/15/2021 | Putnam Investments LLC | 238,438 | $3.74M | 0.0% | -56.6% | 0.642% |  |
| 11/15/2021 | Trustees of Columbia University in the City of New York | 91,910 | $1.44M | 2.2% | -50.0% | 0.247% |  |
| 11/12/2021 | Johnson & Johnson | 1,074,658 | $16.85M | 1.5% | N/A | 2.882% |  |
| 11/12/2021 | Geode Capital Management LLC | 271,937 | $4.26M | 0.0% | +39.7% | 0.732% |  |
| 11/10/2021 | Citigroup Inc. | 2,165 | $34K | 0.0% | +299.4% | 0.006% |  |