| 11/17/2025 | Verition Fund Management LLC | 10,320 | $0.22M | 0.0% | -80.9% | 0.011% |  |
| 11/17/2025 | Susquehanna Fundamental Investments LLC | 101,083 | $2.18M | 0.1% | -9.4% | 0.106% |  |
| 11/17/2025 | Paradigm Biocapital Advisors LP | 2,609,353 | $56.31M | 1.6% | -4.8% | 2.734% |  |
| 11/17/2025 | Parkman Healthcare Partners LLC | 1,154,487 | $24.91M | 2.6% | -11.1% | 1.210% |  |
| 11/17/2025 | Millennium Management LLC | 136,280 | $2.94M | 0.0% | +129.3% | 0.143% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,862 | $0.77M | 0.0% | -14.2% | 0.038% |  |
| 11/17/2025 | Larson Financial Group LLC | 2,407 | $52K | 0.0% | N/A | 0.003% |  |
| 11/17/2025 | HighVista Strategies LLC | 469,335 | $10.13M | 2.5% | -3.1% | 0.492% |  |
| 11/17/2025 | Commodore Capital LP | 3,200,000 | $69.06M | 3.4% | -34.4% | 3.353% |  |
| 11/17/2025 | Bank of America Corp DE | 245,759 | $5.30M | 0.0% | +6.5% | 0.257% |  |
| 11/17/2025 | Boothbay Fund Management LLC | 83,594 | $1.80M | 0.0% | -54.2% | 0.088% |  |
| 11/17/2025 | Alliancebernstein L.P. | 1,859,458 | $40.13M | 0.0% | -4.3% | 1.948% |  |
| 11/14/2025 | Schonfeld Strategic Advisors LLC | 57,928 | $1.25M | 0.0% | -58.3% | 0.061% |  |
| 11/14/2025 | Raymond James Financial Inc. | 312,759 | $6.75M | 0.0% | -5.8% | 0.328% |  |
| 11/14/2025 | ADAR1 Capital Management LLC | 101,704 | $2.20M | 0.2% | -40.4% | 0.107% |  |
| 11/14/2025 | UBS AM A Distinct Business Unit of UBS Asset Management Americas LLC | 138,980 | $3M | 0.0% | -26.9% | 0.146% |  |
| 11/14/2025 | Two Sigma Investments LP | 22,011 | $0.48M | 0.0% | -68.5% | 0.023% |  |
| 11/14/2025 | Wellington Management Group LLP | 1,122,532 | $24.22M | 0.0% | +314.9% | 1.176% |  |
| 11/14/2025 | Glenmede Investment Management LP | 9,940 | $0.22M | 0.0% | -16.0% | 0.010% |  |
| 11/13/2025 | Marshall Wace LLP | 869,188 | $18.76M | 0.0% | -28.0% | 0.911% |  |
| 11/13/2025 | Rosalind Advisors Inc. | 600,000 | $12.95M | 4.6% | -14.3% | 0.629% |  |
| 11/13/2025 | Sei Investments Co. | 11,556 | $0.25M | 0.0% | +10.0% | 0.012% |  |
| 11/13/2025 | UBS Group AG | 447,677 | $9.66M | 0.0% | -16.1% | 0.469% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 242,307 | $5.23M | 0.0% | +27.4% | 0.254% |  |
| 11/13/2025 | Swiss National Bank | 110,700 | $2.39M | 0.0% | +1.7% | 0.116% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 134,997 | $2.91M | 0.0% | +53.6% | 0.141% |  |
| 11/13/2025 | Knott David M Jr | 116,574 | $2.52M | 1.0% | +27.4% | 0.122% |  |
| 11/12/2025 | Barclays PLC | 208,246 | $4.49M | 0.0% | -9.9% | 0.218% |  |
| 11/12/2025 | Propel Bio Management LLC | 90,000 | $1.94M | 1.9% | N/A | 0.094% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 638,777 | $13.79M | 0.0% | +31.5% | 0.669% |  |
| 11/12/2025 | Legato Capital Management LLC | 9,796 | $0.21M | 0.0% | N/A | 0.010% |  |
| 11/12/2025 | Victory Capital Management Inc. | 432,420 | $9.33M | 0.0% | -23.4% | 0.453% |  |
| 11/12/2025 | Fisher Asset Management LLC | 1,201,226 | $25.92M | 0.0% | +135.6% | 1.259% |  |
| 11/12/2025 | Rafferty Asset Management LLC | 68,065 | $1.47M | 0.0% | -10.9% | 0.071% |  |
| 11/12/2025 | Aster Capital Management DIFC Ltd | 1,632 | $35K | 0.0% | N/A | 0.002% |  |
| 11/12/2025 | Intech Investment Management LLC | 34,126 | $0.74M | 0.0% | -32.6% | 0.036% |  |
| 11/12/2025 | US Bancorp DE | 2,457 | $53K | 0.0% | +23.2% | 0.003% |  |
| 11/10/2025 | TD Asset Management Inc | 78,800 | $1.70M | 0.0% | -12.1% | 0.083% |  |
| 11/10/2025 | Clearstead Advisors LLC | 5,000 | $0.11M | 0.0% | +3,868.3% | 0.005% |  |
| 11/10/2025 | Ameritas Investment Partners Inc. | 5,865 | $0.13M | 0.0% | -17.3% | 0.006% |  |
| 11/10/2025 | BIT Capital GmbH | 6,005 | $0.13M | 0.0% | +70.0% | 0.006% |  |
| 11/7/2025 | Vanguard Group Inc. | 4,331,983 | $93.48M | 0.0% | -3.9% | 5.304% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 309,133 | $6.67M | 0.0% | -25.7% | 0.379% |  |
| 11/6/2025 | Rhumbline Advisers | 104,360 | $2.25M | 0.0% | -2.8% | 0.128% |  |
| 11/6/2025 | Profund Advisors LLC | 15,331 | $0.33M | 0.0% | -6.9% | 0.019% |  |
| 11/6/2025 | ProShare Advisors LLC | 12,006 | $0.26M | 0.0% | -15.7% | 0.015% |  |
| 11/6/2025 | Candriam S.C.A. | 860,232 | $18.56M | 0.1% | -0.2% | 1.053% |  |
| 11/5/2025 | Alps Advisors Inc. | 39,961 | $0.86M | 0.0% | -9.1% | 0.049% |  |
| 11/5/2025 | Bessemer Group Inc. | 2,085 | $45K | 0.0% | +947.7% | 0.003% |  |
| 11/4/2025 | Principal Financial Group Inc. | 213,329 | $4.60M | 0.0% | +4.7% | 0.261% |  |
| 11/3/2025 | AlphaQuest LLC | 17,645 | $0.38M | 0.0% | +1,695.0% | 0.022% |  |
| 11/3/2025 | Knights of Columbus Asset Advisors LLC | 59,410 | $1.28M | 0.1% | +2.4% | 0.073% |  |
| 11/3/2025 | J. Safra Sarasin Holding AG | 51,703 | $1.12M | 0.0% | -69.8% | 0.063% |  |
| 10/31/2025 | Y Intercept Hong Kong Ltd | 64,594 | $1.39M | 0.0% | +430.3% | 0.079% |  |
| 10/28/2025 | Campbell & CO Investment Adviser LLC | 26,315 | $0.57M | 0.0% | N/A | 0.032% |  |
| 10/23/2025 | SG Americas Securities LLC | 62,118 | $1.34M | 0.0% | +411.8% | 0.076% |  |
| 10/22/2025 | Hennion & Walsh Asset Management Inc. | 154,338 | $3.33M | 0.1% | -8.3% | 0.189% |  |
| 10/21/2025 | Moody Aldrich Partners LLC | 74,113 | $1.60M | 0.3% | -16.9% | 0.091% |  |
| 10/20/2025 | Simplify Asset Management Inc. | 50,000 | $1.08M | 0.0% | N/A | 0.061% |  |
| 10/16/2025 | Kopp Family Office LLC | 193,830 | $4.18M | 2.7% | -4.6% | 0.237% |  |
| 10/16/2025 | Rice Hall James & Associates LLC | 851,663 | $18.38M | 1.0% | +65.2% | 1.043% |  |
| 10/14/2025 | Farther Finance Advisors LLC | 1,940 | $42K | 0.0% | +332.1% | 0.002% |  |
| 10/9/2025 | Voya Investment Management LLC | 12,791 | $0.28M | 0.0% | -36.1% | 0.016% |  |
| 8/18/2025 | Hudson Bay Capital Management LP | 119,562 | $1.67M | 0.0% | N/A | 0.146% |  |
| 8/15/2025 | Tower Research Capital LLC TRC | 16,227 | $0.23M | 0.0% | +867.0% | 0.020% |  |
| 8/15/2025 | Rafferty Asset Management LLC | 76,412 | $1.07M | 0.0% | -27.8% | 0.094% |  |
| 8/15/2025 | Rosalind Advisors Inc. | 700,000 | $9.79M | 4.4% | +17.6% | 0.857% |  |
| 8/15/2025 | Perceptive Advisors LLC | 447,507 | $6.26M | 0.6% | -32.2% | 0.548% |  |
| 8/15/2025 | Hudson Bay Capital Management LP | 119,562 | $1.67M | 0.0% | N/A | 0.146% |  |
| 8/15/2025 | Engineers Gate Manager LP | 16,504 | $0.23M | 0.0% | -15.9% | 0.020% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 190,229 | $2.66M | 0.0% | +37.0% | 0.233% |  |
| 8/15/2025 | Boothbay Fund Management LLC | 182,452 | $2.55M | 0.1% | +25.6% | 0.223% |  |
| 8/15/2025 | Bank of America Corp DE | 230,844 | $3.23M | 0.0% | +28.2% | 0.283% |  |
| 8/15/2025 | Adage Capital Partners GP L.L.C. | 1,108,586 | $15.50M | 0.0% | -0.5% | 1.358% |  |
| 8/15/2025 | Ameriprise Financial Inc. | 23,131 | $0.32M | 0.0% | -60.3% | 0.028% |  |
| 8/14/2025 | Commodore Capital LP | 4,875,000 | $68.15M | 4.8% | +35.4% | 5.970% |  |
| 8/14/2025 | California State Teachers Retirement System | 53,689 | $0.75M | 0.0% | -1.9% | 0.066% |  |
| 8/14/2025 | Raymond James Financial Inc. | 332,089 | $4.64M | 0.0% | +4.4% | 0.407% |  |
| 8/14/2025 | Maverick Capital Ltd. | 2,257,010 | $31.55M | 0.5% | +9.5% | 2.764% |  |
| 8/14/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,798 | $0.59M | 0.0% | -15.2% | 0.051% |  |
| 8/14/2025 | Alliancebernstein L.P. | 1,944,020 | $27.18M | 0.0% | -3.8% | 2.381% |  |
| 8/14/2025 | The Manufacturers Life Insurance Company | 78,515 | $1.10M | 0.0% | +30.3% | 0.096% |  |
| 8/14/2025 | Sei Investments Co. | 10,510 | $0.15M | 0.0% | N/A | 0.013% |  |
| 8/14/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 131,294 | $1.84M | 0.1% | +22.6% | 0.161% |  |
| 8/14/2025 | HighVista Strategies LLC | 484,559 | $6.77M | 2.5% | +168.4% | 0.593% |  |
| 8/14/2025 | Diadema Partners LP | 122,061 | $1.71M | 0.5% | -24.7% | 0.149% |  |
| 8/14/2025 | Velan Capital Investment Management LP | 86,500 | $1.21M | 1.2% | N/A | 0.106% |  |
| 8/13/2025 | Marshall Wace LLP | 1,207,871 | $16.89M | 0.0% | +11.4% | 1.479% |  |
| 8/13/2025 | Walleye Capital LLC | 64,556 | $0.90M | 0.0% | -42.4% | 0.079% |  |
| 8/13/2025 | Invesco Ltd. | 62,217 | $0.87M | 0.0% | +30.2% | 0.076% |  |
| 8/13/2025 | Fisher Asset Management LLC | 509,959 | $7.13M | 0.0% | -5.0% | 0.624% |  |
| 8/13/2025 | Panagora Asset Management Inc. | 351,852 | $4.92M | 0.0% | -0.8% | 0.431% |  |
| 8/13/2025 | Loomis Sayles & Co. L P | 1,338,472 | $18.71M | 0.0% | -2.3% | 1.639% |  |
| 8/13/2025 | Virtus Investment Advisers LLC | 6,001 | $84K | 0.0% | -34.3% | 0.007% |  |
| 8/13/2025 | Russell Investments Group Ltd. | 87,885 | $1.23M | 0.0% | -55.7% | 0.108% |  |
| 8/12/2025 | American Century Companies Inc. | 104,567 | $1.46M | 0.0% | -14.9% | 0.128% |  |
| 8/12/2025 | Rhumbline Advisers | 107,385 | $1.50M | 0.0% | +2.7% | 0.132% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 415,989 | $5.82M | 0.0% | +39.3% | 0.509% |  |
| 8/12/2025 | Swiss National Bank | 108,900 | $1.52M | 0.0% | +1.3% | 0.133% |  |
| 8/11/2025 | Knott David M Jr | 91,483 | $1.28M | 0.6% | +204.9% | 0.112% |  |