| 11/17/2025 | Acorn Capital Advisors LLC | 586,572 | $0.20M | 0.1% | -20.4% | 1.762% |  |
| 11/17/2025 | Baker BROS. Advisors LP | 851,353 | $0.29M | 0.0% | N/A | 2.557% |  |
| 11/14/2025 | Shay Capital LLC | 492,577 | $0.17M | 0.0% | N/A | 1.934% |  |
| 11/14/2025 | Two Sigma Investments LP | 220,788 | $74K | 0.0% | N/A | 0.867% |  |
| 8/15/2025 | Exome Asset Management LLC | 208,970 | $0.35M | 0.2% | -54.8% | 1.374% |  |
| 8/15/2025 | Boothbay Fund Management LLC | 106,459 | $0.18M | 0.0% | N/A | 0.700% |  |
| 8/15/2025 | Acorn Capital Advisors LLC | 736,572 | $1.22M | 0.8% | -6.3% | 4.843% |  |
| 8/15/2025 | Adage Capital Partners GP L.L.C. | 644,134 | $1.06M | 0.0% | +87.2% | 4.235% |  |
| 8/14/2025 | Jane Street Group LLC | 124,822 | $0.21M | 0.0% | N/A | 0.821% |  |
| 8/14/2025 | TFG Asset Management GP Ltd | 115,384 | $0.19M | 0.0% | N/A | 0.759% |  |
| 8/14/2025 | Velan Capital Investment Management LP | 30,000 | $50K | 0.0% | N/A | 0.197% |  |
| 8/13/2025 | Kennedy Capital Management LLC | 570,740 | $0.94M | 0.0% | N/A | 3.752% |  |
| 8/11/2025 | Patient Square Capital LP | 317,033 | $0.52M | 0.2% | +23.3% | 2.084% |  |
| 5/19/2025 | Acorn Capital Advisors LLC | 785,938 | $1.24M | 0.8% | +72.0% | 5.167% |  |
| 5/16/2025 | Exome Asset Management LLC | 462,801 | $0.73M | 0.6% | +30.9% | 3.043% |  |
| 5/16/2025 | Parkman Healthcare Partners LLC | 217,978 | $0.34M | 0.0% | +42.5% | 1.433% |  |
| 5/16/2025 | Adage Capital Partners GP L.L.C. | 344,134 | $0.54M | 0.0% | +123.3% | 2.263% |  |
| 5/16/2025 | ADAR1 Capital Management LLC | 70,419 | $0.11M | 0.0% | N/A | 0.463% |  |
| 5/15/2025 | DAFNA Capital Management LLC | 636,103 | $1.01M | 0.3% | N/A | 4.182% |  |
| 5/12/2025 | Virtu Financial LLC | 19,574 | $31K | 0.0% | N/A | 0.129% |  |
| 5/8/2025 | XTX Topco Ltd | 33,052 | $52K | 0.0% | +57.3% | 0.217% |  |
| 2/17/2025 | Parkman Healthcare Partners LLC | 152,973 | $0.51M | 0.1% | -24.6% | 1.037% |  |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 245,800 | $0.82M | 0.1% | N/A | 1.666% |  |
| 2/17/2025 | Bridgeway Capital Management LLC | 36,958 | $0.12M | 0.0% | N/A | 0.251% |  |
| 2/17/2025 | Acorn Capital Advisors LLC | 456,970 | $1.53M | 0.8% | N/A | 3.098% |  |
| 2/14/2025 | Jane Street Group LLC | 20,286 | $68K | 0.0% | N/A | 0.138% |  |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 176,658 | $0.59M | 0.0% | +4.8% | 1.198% |  |
| 2/14/2025 | Northern Trust Corp | 23,971 | $80K | 0.0% | -35.7% | 0.163% |  |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 154,134 | $0.52M | 0.0% | N/A | 1.045% |  |
| 2/13/2025 | XTX Topco Ltd | 21,018 | $70K | 0.0% | N/A | 0.142% |  |
| 2/13/2025 | Renaissance Technologies LLC | 24,943 | $84K | 0.0% | -71.2% | 0.169% |  |
| 11/15/2024 | Parkman Healthcare Partners LLC | 202,973 | $0.38M | 0.0% | -41.2% | 1.376% |  |
| 10/30/2024 | AlphaCentric Advisors LLC | 268,485 | $0.51M | 0.4% | -13.5% | 1.820% |  |
| 8/15/2024 | Lynx1 Capital Management LP | 16,194 | $32K | 0.0% | N/A | 0.111% |  |
| 8/9/2024 | Renaissance Technologies LLC | 63,111 | $0.12M | 0.0% | -21.7% | 0.434% |  |
| 7/26/2024 | AlphaCentric Advisors LLC | 310,500 | $0.61M | 0.5% | -30.2% | 2.137% |  |
| 5/20/2024 | Virtu Financial LLC | 16,199 | $50K | 0.0% | N/A | 0.112% |  |
| 2/20/2024 | Eventide Asset Management LLC | 1,394,336 | $3.25M | 0.1% | N/A | 9.988% |  |
| 2/15/2024 | Parkman Healthcare Partners LLC | 696,470 | $1.62M | 0.2% | N/A | 4.990% |  |
| 5/15/2023 | DSC Advisors L.P. | 115,000 | $0.35M | 0.3% | -92.7% | 3.523% |  |
| 5/10/2023 | Staley Capital Advisers Inc. | 23,472 | $72K | 0.0% | -62.4% | 0.720% |  |
| 10/7/2022 | Mackenzie Financial Corp | 134,920 | $30K | 0.0% | +106.8% | 0.233% |  |
| 4/25/2022 | Bailard Inc. | 139,381 | $91K | 0.0% | N/A | 0.248% |  |
| 2/15/2022 | DSC Advisors L.P. | 2,551,000 | $2.60M | 2.0% | +131.9% | 4.767% |  |
| 2/14/2022 | Perceptive Advisors LLC | 2,178,022 | $2.22M | 0.0% | -6.5% | 4.070% |  |
| 2/14/2022 | GSA Capital Partners LLP | 217,747 | $0.22M | 0.0% | +135.7% | 0.407% |  |
| 1/24/2022 | SkyOak Wealth LLC | 27,200 | $28K | 0.0% | N/A | 0.051% |  |
| 12/3/2021 | Perceptive Advisors LLC | 2,330,471 | $3.24M | 0.0% | -59.6% | 4.355% |  |
| 11/16/2021 | Thrivent Financial for Lutherans | 71,990 | $0.10M | 0.0% | +20.2% | 0.140% |  |
| 11/15/2021 | 683 Capital Management LLC | 715,386 | $0.99M | 0.0% | -2.5% | 1.389% |  |
| 11/15/2021 | Healthcare Value Capital LLC | 400,000 | $0.56M | 1.1% | -11.1% | 0.777% |  |
| 11/15/2021 | Franklin Resources Inc. | 1,921,236 | $2.67M | 0.0% | +1.1% | 3.730% |  |
| 11/15/2021 | GSA Capital Partners LLP | 92,402 | $0.13M | 0.0% | N/A | 0.179% |  |
| 11/12/2021 | Renaissance Technologies LLC | 1,245,027 | $1.73M | 0.0% | +300.4% | 2.417% |  |
| 11/5/2021 | Staley Capital Advisers Inc. | 50,000 | $70K | 0.0% | +33.3% | 0.097% |  |
| 10/29/2021 | Banque Cantonale Vaudoise | 80,000 | $0.11M | 0.0% | -60.0% | 0.155% |  |
| 9/24/2021 | Thrivent Financial for Lutherans | 59,884 | $0.21M | 0.0% | N/A | 0.116% |  |
| 8/17/2021 | Price T Rowe Associates Inc. MD | 40,050 | $0.14M | 0.0% | +23.5% | 0.078% |  |