| 11/17/2025 | Susquehanna International Group LLP | 93,041 | $0.18M | 0.0% | +16.9% | 0.192% |  |
| 11/17/2025 | Qube Research & Technologies Ltd | 29,250 | $58K | 0.0% | -33.9% | 0.060% |  |
| 11/17/2025 | Millennium Management LLC | 317,053 | $0.63M | 0.0% | -54.5% | 0.653% |  |
| 11/17/2025 | Citadel Advisors LLC | 154,534 | $0.30M | 0.0% | N/A | 0.318% |  |
| 11/17/2025 | Bank of America Corp DE | 1,830,292 | $3.61M | 0.0% | -14.0% | 3.771% |  |
| 11/14/2025 | Two Sigma Investments LP | 20,139 | $40K | 0.0% | -55.7% | 0.041% |  |
| 11/7/2025 | Vanguard Group Inc. | 1,408,047 | $2.77M | 0.0% | +8.5% | 2.901% |  |
| 8/15/2025 | Bridgeway Capital Management LLC | 102,000 | $0.11M | 0.0% | +157.7% | 0.227% |  |
| 8/15/2025 | Bank of America Corp DE | 2,129,024 | $2.32M | 0.0% | +1.2% | 4.745% |  |
| 8/14/2025 | Jane Street Group LLC | 374,939 | $0.41M | 0.0% | N/A | 0.836% |  |
| 8/14/2025 | Qube Research & Technologies Ltd | 44,261 | $48K | 0.0% | N/A | 0.099% |  |
| 8/13/2025 | Marshall Wace LLP | 103,785 | $0.11M | 0.0% | N/A | 0.231% |  |
| 8/13/2025 | Quadrature Capital Ltd | 25,791 | $28K | 0.0% | N/A | 0.057% |  |
| 8/8/2025 | Geode Capital Management LLC | 327,955 | $0.36M | 0.0% | -54.3% | 0.731% |  |
| 8/1/2025 | Y Intercept Hong Kong Ltd | 84,421 | $92K | 0.0% | N/A | 0.188% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 111,985 | $0.11M | 0.0% | -21.0% | 0.250% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 111,985 | $0.11M | 0.0% | -21.0% | 0.250% |  |
| 5/16/2025 | AQR Capital Management LLC | 81,669 | $79K | 0.0% | N/A | 0.182% |  |
| 5/15/2025 | MPM Bioimpact LLC | 2,408,810 | $2.34M | 0.4% | +0.9% | 5.368% |  |
| 5/15/2025 | MPM Asset Management LLC | 4,309,860 | $4.19M | 6.0% | +0.6% | 9.604% |  |
| 5/14/2025 | Walleye Capital LLC | 59,347 | $58K | 0.0% | -38.7% | 0.132% |  |
| 5/12/2025 | Nuveen LLC | 73,370 | $71K | 0.0% | N/A | 0.164% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 95,712 | $93K | 0.0% | +33.2% | 0.213% |  |
| 4/28/2025 | Vontobel Holding Ltd. | 35,000 | $34K | 0.0% | N/A | 0.078% |  |
| 2/17/2025 | Two Sigma Investments LP | 93,440 | $0.14M | 0.0% | -48.3% | 0.210% |  |
| 2/17/2025 | Two Sigma Advisers LP | 139,100 | $0.21M | 0.0% | -45.7% | 0.312% |  |
| 2/17/2025 | Millennium Management LLC | 596,289 | $0.88M | 0.0% | -55.0% | 1.338% |  |
| 2/17/2025 | Deutsche Bank AG | 101,626 | $0.15M | 0.0% | +450.7% | 0.228% |  |
| 2/17/2025 | D. E. Shaw & Co. Inc. | 17,776 | $26K | 0.0% | N/A | 0.040% |  |
| 2/17/2025 | Bridgeway Capital Management LLC | 109,586 | $0.16M | 0.0% | +24.4% | 0.246% |  |
| 2/17/2025 | Bank of America Corp DE | 2,078,875 | $3.08M | 0.0% | -3.5% | 4.665% |  |
| 2/14/2025 | Jane Street Group LLC | 54,713 | $81K | 0.0% | +261.2% | 0.123% |  |
| 2/14/2025 | Northern Trust Corp | 244,390 | $0.36M | 0.0% | +7.3% | 0.548% |  |
| 2/14/2025 | Dimensional Fund Advisors LP | 194,746 | $0.29M | 0.0% | -24.5% | 0.437% |  |
| 2/13/2025 | Regal Investment Advisors LLC | 27,204 | $40K | 0.0% | +88.1% | 0.061% |  |
| 2/13/2025 | Walleye Capital LLC | 96,850 | $0.14M | 0.0% | -11.1% | 0.217% |  |
| 2/13/2025 | Renaissance Technologies LLC | 56,900 | $84K | 0.0% | -62.6% | 0.128% |  |
| 2/12/2025 | Geode Capital Management LLC | 702,558 | $1.04M | 0.0% | +2.4% | 1.577% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 62,928 | $93K | 0.0% | +372.4% | 0.141% |  |
| 2/5/2025 | Levin Capital Strategies L.P. | 50,000 | $74K | 0.0% | N/A | 0.112% |  |
| 2/4/2025 | Bank of New York Mellon Corp | 71,300 | $0.11M | 0.0% | +23.1% | 0.160% |  |
| 11/19/2024 | Barclays PLC | 54,810 | $0.12M | 0.0% | +130.1% | 0.123% |  |
| 11/16/2024 | Geode Capital Management LLC | 685,989 | $1.45M | 0.0% | +6.3% | 1.539% |  |
| 11/15/2024 | Barclays PLC | 54,810 | $0.12M | 0.0% | +130.1% | 0.123% |  |
| 11/15/2024 | XTX Topco Ltd | 21,209 | $45K | 0.0% | N/A | 0.048% |  |
| 11/15/2024 | Jane Street Group LLC | 15,149 | $32K | 0.0% | -47.0% | 0.034% |  |
| 11/15/2024 | State Street Corp | 476,439 | $1.01M | 0.0% | +12.4% | 1.069% |  |
| 11/15/2024 | Point72 Asset Management L.P. | 109,816 | $0.23M | 0.0% | -70.5% | 0.246% |  |
| 11/14/2024 | PFM Health Sciences LP | 3,398,747 | $7.21M | 0.4% | +4.9% | 7.627% |  |
| 11/14/2024 | Walleye Capital LLC | 108,968 | $0.23M | 0.0% | +10.7% | 0.245% |  |
| 10/3/2024 | SG Americas Securities LLC | 13,517 | $29K | 0.0% | N/A | 0.031% |  |
| 9/16/2024 | Point72 DIFC Ltd | 14,046 | $34K | 0.0% | N/A | 0.032% |  |
| 9/16/2024 | Cubist Systematic Strategies LLC | 28,371 | $69K | 0.0% | -30.2% | 0.065% |  |
| 8/16/2024 | Murchinson Ltd. | 62,500 | $0.15M | 0.0% | N/A | 0.144% |  |
| 8/15/2024 | Millennium Management LLC | 1,110,298 | $2.71M | 0.0% | +96.4% | 2.555% |  |
| 8/14/2024 | Cubist Systematic Strategies LLC | 28,371 | $69K | 0.0% | -30.2% | 0.065% |  |
| 8/14/2024 | Murchinson Ltd. | 62,500 | $0.15M | 0.0% | N/A | 0.144% |  |
| 8/14/2024 | Point72 DIFC Ltd | 14,046 | $34K | 0.0% | N/A | 0.032% |  |
| 8/14/2024 | Marshall Wace LLP | 134,184 | $0.33M | 0.0% | +410.5% | 0.309% |  |
| 8/13/2024 | Rubric Capital Management LP | 1,333,893 | $3.26M | 0.1% | -17.7% | 3.070% |  |
| 8/9/2024 | Renaissance Technologies LLC | 171,000 | $0.42M | 0.0% | +103.1% | 0.394% |  |
| 8/9/2024 | Dimensional Fund Advisors LP | 160,577 | $0.39M | 0.0% | +43.9% | 0.370% |  |
| 8/8/2024 | American Century Companies Inc. | 37,634 | $92K | 0.0% | +50.7% | 0.087% |  |
| 8/6/2024 | Acadian Asset Management LLC | 212,296 | $0.52M | 0.0% | +22.8% | 0.489% |  |
| 8/1/2024 | Rhumbline Advisers | 32,547 | $79K | 0.0% | N/A | 0.075% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 67,644 | $0.17M | 0.0% | N/A | 0.156% |  |
| 5/16/2024 | Janus Henderson Group PLC | 1,688,054 | $10.92M | 0.0% | N/A | 3.884% |  |
| 5/10/2024 | Acadian Asset Management LLC | 172,883 | $1.12M | 0.0% | +119.8% | 0.399% |  |
| 5/10/2024 | Vanguard Group Inc. | 1,107,347 | $7.18M | 0.0% | +26.8% | 2.554% |  |
| 5/9/2024 | HBK Sorce Advisory LLC | 13,227 | $86K | 0.0% | -50.0% | 0.031% |  |
| 4/19/2024 | Denali Advisors LLC | 26,600 | $0.17M | 0.1% | N/A | 0.061% |  |
| 2/15/2024 | PFM Health Sciences LP | 3,468,177 | $13.39M | 0.8% | +35.6% | 8.529% |  |
| 2/14/2024 | Lighthouse Investment Partners LLC | 22,472 | $87K | 0.0% | N/A | 0.055% |  |
| 2/5/2024 | Certuity LLC | 10,000 | $39K | 0.0% | N/A | 0.028% |  |
| 2/1/2024 | Financial Perspectives Inc | 6,750 | $26K | 0.0% | +80.0% | 0.019% |  |
| 8/4/2023 | HBK Sorce Advisory LLC | 26,454 | $81K | 0.0% | -50.0% | 0.074% |  |
| 5/15/2023 | Rubric Capital Management LP | 1,935,357 | $5.03M | 0.1% | +5.4% | 5.449% |  |
| 5/8/2023 | Bailard Inc. | 18,127 | $47K | 0.0% | N/A | 0.051% |  |
| 2/9/2023 | Chicago Partners Investment Group LLC | 10,729 | $41K | 0.0% | N/A | 0.035% |  |
| 11/15/2022 | PFM Health Sciences LP | 2,815,654 | $12.70M | 0.5% | +62.7% | 9.158% |  |
| 11/15/2022 | Platinum Investment Management Ltd. | 109,530 | $0.49M | 0.0% | -48.7% | 0.356% |  |
| 11/15/2022 | Laurion Capital Management LP | 522,900 | $2.36M | 0.0% | -2.3% | 1.700% |  |
| 11/14/2022 | Ergoteles LLC | 114,595 | $0.52M | 0.0% | -11.2% | 0.388% |  |
| 11/14/2022 | Rubric Capital Management LP | 966,879 | $4.36M | 0.2% | +371.7% | 3.274% |  |
| 10/25/2022 | Denali Advisors LLC | 5,900 | $27K | 0.0% | N/A | 0.020% |  |
| 8/15/2022 | Laurion Capital Management LP | 535,160 | $2.19M | 0.0% | N/A | 1.935% |  |
| 8/8/2022 | Y Intercept Hong Kong Ltd | 11,124 | $45K | 0.0% | N/A | 0.040% |  |
| 7/27/2022 | Bailard Inc. | 21,200 | $87K | 0.0% | N/A | 0.077% |  |
| 5/11/2022 | Granite Point Capital Management L.P. | 55,000 | $0.24M | 0.1% | +266.7% | 0.199% |  |
| 2/15/2022 | Adage Capital Partners GP L.L.C. | 960,448 | $11.44M | 0.0% | -2.5% | 3.483% |  |
| 2/14/2022 | Deerfield Management Company L.P. Series C | 958,125 | $11.41M | 0.2% | -45.3% | 3.474% |  |
| 2/14/2022 | Soleus Capital Management L.P. | 64,585 | $0.77M | 0.1% | -88.5% | 0.234% |  |
| 2/11/2022 | Granite Point Capital Management L.P. | 15,000 | $0.18M | 0.0% | N/A | 0.054% |  |
| 2/8/2022 | Northern Trust Corp | 200,065 | $2.38M | 0.0% | +184.2% | 0.725% |  |
| 11/15/2021 | Deerfield Management Company L.P. Series C | 1,752,787 | $30.08M | 0.6% | -31.3% | 6.358% |  |
| 11/15/2021 | Sphera Funds Management LTD. | 688,475 | $11.81M | 1.0% | -2.5% | 2.497% |  |
| 11/15/2021 | Caas Capital Management LP | 162,599 | $2.79M | 0.1% | +62.6% | 0.590% |  |
| 11/12/2021 | Geode Capital Management LLC | 136,472 | $2.34M | 0.0% | +26.2% | 0.495% |  |
| 11/10/2021 | Levin Capital Strategies L.P. | 15,000 | $0.26M | 0.0% | N/A | 0.054% |  |
| 11/9/2021 | BlackRock Inc. | 369,961 | $6.35M | 0.0% | +1.1% | 1.342% |  |