| 11/17/2025 | Acorn Capital Advisors LLC | 273,349 | $0.94M | 0.5% | +77.8% | 0.313% |  |
| 11/17/2025 | Nantahala Capital Management LLC | 2,228,350 | $7.62M | 0.3% | N/A | 2.548% |  |
| 11/17/2025 | Millennium Management LLC | 64,795 | $0.22M | 0.0% | -17.0% | 0.074% |  |
| 11/17/2025 | Kingdon Capital Management L.L.C. | 933,332 | $3.19M | 0.4% | +300.0% | 1.067% |  |
| 11/17/2025 | Bank of America Corp DE | 19,304 | $66K | 0.0% | -76.0% | 0.022% |  |
| 11/17/2025 | Boothbay Fund Management LLC | 343,963 | $1.18M | 0.0% | N/A | 0.393% |  |
| 11/14/2025 | Deep Track Capital LP | 1,122,484 | $3.84M | 0.1% | N/A | 9.838% |  |
| 11/14/2025 | Two Sigma Investments LP | 13,868 | $47K | 0.0% | N/A | 0.122% |  |
| 11/13/2025 | Rosalind Advisors Inc. | 1,544,607 | $5.28M | 1.9% | N/A | 13.537% |  |
| 11/10/2025 | Palumbo Wealth Management LLC | 95,327 | $0.33M | 0.1% | N/A | 0.835% |  |
| 11/7/2025 | Vanguard Group Inc. | 410,485 | $1.40M | 0.0% | +77.0% | 3.598% |  |
| 8/15/2025 | Bain Capital Life Sciences Investors LLC | 563,859 | $1.07M | 0.1% | -96.7% | 9.738% |  |
| 8/15/2025 | Acorn Capital Advisors LLC | 153,730 | $0.29M | 0.2% | -97.9% | 2.655% |  |
| 8/14/2025 | Jane Street Group LLC | 97,344 | $0.19M | 0.0% | +112.5% | 1.681% |  |
| 8/14/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 80,000 | $0.15M | 0.0% | -68.3% | 1.382% |  |
| 8/14/2025 | Pale Fire Capital SE | 60,051 | $0.11M | 0.0% | -97.0% | 1.037% |  |
| 8/8/2025 | Geode Capital Management LLC | 49,146 | $93K | 0.0% | -98.6% | 0.849% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 273,865 | $65K | 0.0% | -42.7% | 4.730% |  |
| 5/29/2025 | Rhumbline Advisers | 188,415 | $44K | 0.0% | +5.4% | 3.255% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 273,865 | $65K | 0.0% | -42.7% | 4.731% |  |
| 5/15/2025 | Kingdon Capital Management L.L.C. | 7,000,000 | $1.66M | 0.2% | +41.8% | 120.919% |  |
| 5/14/2025 | Pale Fire Capital SE | 2,035,362 | $0.48M | 0.1% | +45.2% | 35.159% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 481,528 | $0.11M | 0.0% | +9.9% | 8.318% |  |
| 2/17/2025 | Point72 Asset Management L.P. | 650,000 | $0.48M | 0.0% | +4.0% | 0.381% |  |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,264,358 | $0.93M | 0.1% | -18.4% | 0.741% |  |
| 2/17/2025 | Millennium Management LLC | 258,759 | $0.19M | 0.0% | -28.8% | 0.152% |  |
| 2/17/2025 | Deutsche Bank AG | 267,628 | $0.20M | 0.0% | +559.6% | 0.157% |  |
| 2/17/2025 | Cantor Fitzgerald L. P. | 40,251 | $30K | 0.0% | N/A | 0.024% |  |
| 2/17/2025 | Bank of America Corp DE | 133,502 | $98K | 0.0% | +20.3% | 0.078% |  |
| 2/17/2025 | Acorn Capital Advisors LLC | 7,310,650 | $5.36M | 2.9% | N/A | 4.287% |  |
| 2/14/2025 | Jane Street Group LLC | 583,483 | $0.43M | 0.0% | +134.9% | 0.342% |  |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 1,392,826 | $1.02M | 0.0% | -27.5% | 0.817% |  |
| 2/14/2025 | Northern Trust Corp | 1,357,539 | $1M | 0.0% | +2.9% | 0.796% |  |
| 2/14/2025 | Stifel Financial Corp | 75,607 | $55K | 0.0% | -38.3% | 0.044% |  |
| 2/13/2025 | Invesco Ltd. | 62,073 | $46K | 0.0% | -49.9% | 0.036% |  |
| 2/13/2025 | Wells Fargo & Company MN | 78,518 | $58K | 0.0% | +51.7% | 0.046% |  |
| 2/12/2025 | Geode Capital Management LLC | 3,497,212 | $2.57M | 0.0% | +1.4% | 2.051% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 459,653 | $0.34M | 0.0% | +501.0% | 0.270% |  |
| 1/31/2025 | Atria Wealth Solutions Inc. | 60,000 | $44K | 0.0% | N/A | 0.035% |  |
| 1/17/2025 | SG Americas Securities LLC | 183,152 | $0.13M | 0.0% | +233.0% | 0.107% |  |
| 11/19/2024 | Barclays PLC | 277,682 | $0.19M | 0.0% | +196.0% | 0.163% |  |
| 11/16/2024 | Geode Capital Management LLC | 3,447,512 | $2.31M | 0.0% | -1.9% | 2.046% |  |
| 11/15/2024 | Barclays PLC | 277,682 | $0.19M | 0.0% | +196.0% | 0.165% |  |
| 11/15/2024 | K2 Principal Fund L.P. | 89,158 | $60K | 0.0% | -81.8% | 0.053% |  |
| 11/15/2024 | XTX Topco Ltd | 157,642 | $0.11M | 0.0% | +41.7% | 0.094% |  |
| 11/15/2024 | Jane Street Group LLC | 248,447 | $0.17M | 0.0% | +103.4% | 0.147% |  |
| 11/15/2024 | State Street Corp | 2,952,895 | $1.98M | 0.0% | +6.8% | 1.752% |  |
| 11/15/2024 | Stifel Financial Corp | 122,448 | $82K | 0.0% | -25.5% | 0.073% |  |
| 11/15/2024 | Point72 Asset Management L.P. | 625,052 | $0.42M | 0.0% | +15.1% | 0.371% |  |
| 11/14/2024 | Verition Fund Management LLC | 44,355 | $30K | 0.0% | N/A | 0.026% |  |
| 11/14/2024 | Sio Capital Management LLC | 1,303,508 | $0.87M | 0.3% | -47.9% | 0.774% |  |
| 11/5/2024 | GSA Capital Partners LLP | 507,694 | $0.34M | 0.0% | N/A | 0.301% |  |
| 10/3/2024 | SG Americas Securities LLC | 55,004 | $37K | 0.0% | N/A | 0.033% |  |
| 8/19/2024 | Point72 Asset Management L.P. | 543,084 | $0.32M | 0.0% | -16.4% | 0.323% |  |
| 8/15/2024 | AQR Capital Management LLC | 424,042 | $0.25M | 0.0% | +1,080.3% | 0.252% |  |
| 8/14/2024 | K2 Principal Fund L.P. | 489,158 | $0.28M | 0.1% | N/A | 0.291% |  |
| 8/13/2024 | Ensign Peak Advisors Inc | 2,546,458 | $1.48M | 0.0% | +4.6% | 1.516% |  |
| 8/12/2024 | XTX Topco Ltd | 111,245 | $65K | 0.0% | N/A | 0.066% |  |
| 8/1/2024 | Rhumbline Advisers | 187,246 | $0.11M | 0.0% | +14.6% | 0.111% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 469,372 | $0.27M | 0.0% | +39.7% | 0.279% |  |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 39,307 | $55K | 0.0% | +46.7% | 0.023% |  |
| 5/10/2024 | Vanguard Group Inc. | 7,827,727 | $10.88M | 0.0% | -2.3% | 4.661% |  |
| 5/7/2024 | SG Americas Securities LLC | 20,822 | $29K | 0.0% | -56.3% | 0.012% |  |
| 5/3/2024 | GSA Capital Partners LLP | 321,021 | $0.45M | 0.0% | -66.0% | 0.191% |  |
| 5/1/2024 | BNP Paribas Financial Markets | 61,575 | $86K | 0.0% | -78.3% | 0.037% |  |
| 3/18/2024 | Kingdon Capital Management L.L.C. | 3,473,683 | $2.91M | 0.4% | +76.0% | 2.076% |  |
| 2/13/2024 | Bain Capital Life Sciences Investors LLC | 16,915,784 | $14.18M | 1.4% | +6.0% | 10.112% |  |
| 2/13/2024 | Armistice Capital LLC | 1,936,000 | $1.62M | 0.0% | -17.8% | 1.157% |  |
| 1/12/2024 | SG Americas Securities LLC | 47,668 | $40K | 0.0% | +38.8% | 0.028% |  |
| 11/22/2023 | Polar Capital Holdings Plc | 7,500,000 | $8.18M | 0.1% | -25.0% | 4.483% |  |
| 11/15/2023 | GSA Capital Partners LLP | 621,587 | $0.68M | 0.1% | N/A | 0.372% |  |
| 11/15/2023 | Armistice Capital LLC | 2,356,000 | $2.57M | 0.0% | -20.8% | 1.408% |  |
| 11/14/2023 | Schonfeld Strategic Advisors LLC | 586,042 | $0.64M | 0.0% | -40.4% | 0.350% |  |
| 11/14/2023 | Stonepine Capital Management LLC | 5,273,685 | $5.75M | 1.9% | +14.5% | 3.152% |  |
| 11/14/2023 | Monashee Investment Management LLC | 427,265 | $0.47M | 0.2% | -25.4% | 0.255% |  |
| 11/7/2023 | Barclays PLC | 382,134 | $0.42M | 0.0% | +334.8% | 0.232% |  |
| 10/13/2023 | SG Americas Securities LLC | 34,340 | $37K | 0.0% | N/A | 0.021% |  |
| 9/21/2023 | Barclays PLC | 87,879 | $0.17M | 0.0% | N/A | 0.053% |  |
| 8/24/2023 | Perceptive Advisors LLC | 3,545,454 | $6.88M | 0.2% | -22.0% | 2.156% |  |
| 8/16/2023 | Stonepine Capital Management LLC | 4,605,263 | $8.93M | 3.2% | N/A | 3.768% |  |
| 8/15/2023 | Bain Capital Life Sciences Investors LLC | 15,960,588 | $30.96M | 3.2% | +30.8% | 13.060% |  |
| 8/14/2023 | Polar Capital Holdings Plc | 5,000,000 | $9.70M | 0.1% | N/A | 4.091% |  |
| 8/11/2023 | AWM Investment Company Inc. | 100,000 | $0.19M | 0.0% | N/A | 0.082% |  |
| 8/10/2023 | Monashee Investment Management LLC | 572,784 | $1.11M | 0.3% | N/A | 0.469% |  |
| 8/10/2023 | Private Advisor Group LLC | 19,800 | $38K | 0.0% | N/A | 0.016% |  |
| 8/7/2023 | Principal Financial Group Inc. | 13,804 | $27K | 0.0% | N/A | 0.011% |  |
| 8/7/2023 | Royce & Associates LP | 53,490 | $0.10M | 0.0% | N/A | 0.044% |  |
| 8/4/2023 | American International Group Inc. | 59,261 | $0.12M | 0.0% | N/A | 0.048% |  |
| 7/27/2023 | Virtu Financial LLC | 15,077 | $29K | 0.0% | -86.7% | 0.012% |  |
| 7/24/2023 | Vontobel Holding Ltd. | 45,000 | $87K | 0.0% | N/A | 0.037% |  |
| 7/19/2023 | Grimes & Company Inc. | 15,000 | $29K | 0.0% | N/A | 0.012% |  |
| 5/15/2023 | Ghost Tree Capital LLC | 850,000 | $0.74M | 0.2% | -15.0% | 0.696% |  |
| 5/12/2023 | Scoggin Management LP | 484,796 | $0.57M | 0.3% | N/A | 0.397% |  |
| 5/12/2023 | CIBC Private Wealth Group LLC | 41,500 | $36K | 0.0% | N/A | 0.034% |  |
| 5/10/2023 | Landscape Capital Management L.L.C. | 42,252 | $37K | 0.0% | N/A | 0.035% |  |
| 5/10/2023 | Simplify Asset Management Inc. | 400,000 | $0.35M | 0.0% | N/A | 0.327% |  |
| 5/1/2023 | Virtu Financial LLC | 113,489 | $99K | 0.0% | N/A | 0.094% |  |
| 2/10/2023 | NEA Management Company LLC | 11,736,793 | $11.66M | 0.7% | +79.9% | 16.952% |  |
| 2/7/2023 | Lynwood Capital Management Inc. | 2,155,100 | $2.14M | 2.6% | N/A | 3.113% |  |
| 11/15/2022 | Tri Locum Partners LP | 2,504,006 | $4.28M | 1.2% | +44.0% | 3.617% |  |