| 11/17/2025 | Woodline Partners LP | 209,945 | $8.09M | 0.0% | +16.5% | 1.695% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,312 | $0.17M | 0.0% | -16.1% | 0.035% |  |
| 11/17/2025 | HighVista Strategies LLC | 105,714 | $4.07M | 1.0% | -7.7% | 0.854% |  |
| 11/17/2025 | Citadel Advisors LLC | 7,581 | $0.29M | 0.0% | N/A | 0.061% |  |
| 11/14/2025 | Man Group plc | 6,397 | $0.25M | 0.0% | N/A | 0.053% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 24,980 | $0.96M | 0.0% | -4.7% | 0.207% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 3,226 | $0.12M | 0.0% | +266.6% | 0.027% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 778 | $30K | 0.0% | +3,436.4% | 0.006% |  |
| 11/13/2025 | CM Management LLC | 48,000 | $1.85M | 1.5% | -25.0% | 0.397% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 29,190 | $1.12M | 0.0% | +4.5% | 0.241% |  |
| 11/7/2025 | Vanguard Group Inc. | 668,111 | $25.75M | 0.0% | +4.6% | 5.527% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 3,796 | $0.15M | 0.0% | -14.5% | 0.031% |  |
| 8/15/2025 | Tower Research Capital LLC TRC | 2,273 | $57K | 0.0% | +203.1% | 0.019% |  |
| 8/15/2025 | Opaleye Management Inc. | 255,087 | $6.43M | 1.3% | +0.8% | 2.131% |  |
| 8/15/2025 | BVF Inc. IL | 2,590,303 | $65.28M | 2.3% | -13.2% | 21.640% |  |
| 8/15/2025 | Bank of America Corp DE | 4,200 | $0.11M | 0.0% | -15.3% | 0.035% |  |
| 8/14/2025 | Raymond James Financial Inc. | 4,600 | $0.12M | 0.0% | N/A | 0.038% |  |
| 8/14/2025 | Occudo Quantitative Strategies LP | 20,925 | $0.53M | 0.1% | N/A | 0.175% |  |
| 8/13/2025 | Marshall Wace LLP | 16,308 | $0.41M | 0.0% | +12.2% | 0.136% |  |
| 8/13/2025 | Stonepine Capital Management LLC | 152,143 | $3.83M | 3.8% | +17.2% | 1.271% |  |
| 8/13/2025 | Panagora Asset Management Inc. | 18,379 | $0.46M | 0.0% | N/A | 0.154% |  |
| 8/12/2025 | Rhumbline Advisers | 13,249 | $0.33M | 0.0% | +18.0% | 0.111% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 4,440 | $0.11M | 0.0% | +13.9% | 0.037% |  |
| 8/8/2025 | Geode Capital Management LLC | 203,601 | $5.13M | 0.0% | +9.1% | 1.701% |  |
| 8/7/2025 | Los Angeles Capital Management LLC | 14,676 | $0.37M | 0.0% | N/A | 0.123% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 11,523 | $0.23M | 0.0% | -45.1% | 0.096% |  |
| 5/16/2025 | Woodline Partners LP | 168,550 | $3.36M | 0.0% | +7.9% | 1.410% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 11,523 | $0.23M | 0.0% | -45.1% | 0.096% |  |
| 5/16/2025 | BVF Inc. IL | 2,983,026 | $59.45M | 2.4% | -17.9% | 24.956% |  |
| 5/14/2025 | Stonepine Capital Management LLC | 129,813 | $2.59M | 2.5% | +3.3% | 1.086% |  |
| 5/12/2025 | Nuveen LLC | 14,363 | $0.29M | 0.0% | N/A | 0.120% |  |
| 5/9/2025 | Deutsche Bank AG | 6,433 | $0.13M | 0.0% | +5,087.9% | 0.054% |  |
| 5/9/2025 | CM Management LLC | 64,000 | $1.28M | 1.3% | +16.4% | 0.535% |  |
| 4/28/2025 | Acuitas Investments LLC | 5,674 | $0.11M | 0.1% | -90.7% | 0.047% |  |
| 4/7/2025 | GAMMA Investing LLC | 1,734 | $35K | 0.0% | +1,063.8% | 0.014% |  |
| 2/17/2025 | Woodline Partners LP | 156,266 | $4.11M | 0.0% | +63.9% | 1.326% |  |
| 2/17/2025 | Squarepoint Ops LLC | 9,484 | $0.25M | 0.0% | -28.9% | 0.080% |  |
| 2/17/2025 | Stonepine Capital Management LLC | 125,700 | $3.30M | 2.7% | -35.6% | 1.067% |  |
| 2/17/2025 | Nuveen Asset Management LLC | 14,363 | $0.38M | 0.0% | +3.8% | 0.122% |  |
| 2/17/2025 | Bridgeway Capital Management LLC | 25,500 | $0.67M | 0.0% | -3.4% | 0.216% |  |
| 2/17/2025 | Bank of America Corp DE | 7,796 | $0.21M | 0.0% | +34.7% | 0.066% |  |
| 2/17/2025 | BNP Paribas Financial Markets | 1,109 | $29K | 0.0% | -32.0% | 0.009% |  |
| 2/14/2025 | Northern Trust Corp | 91,181 | $2.40M | 0.0% | +1.5% | 0.774% |  |
| 2/14/2025 | Eversept Partners LP | 95,417 | $2.51M | 0.2% | +1.2% | 0.810% |  |
| 2/13/2025 | Barclays PLC | 12,784 | $0.34M | 0.0% | +13.6% | 0.109% |  |
| 2/13/2025 | Renaissance Technologies LLC | 16,100 | $0.42M | 0.0% | +89.8% | 0.137% |  |
| 2/13/2025 | Wells Fargo & Company MN | 4,300 | $0.11M | 0.0% | +38.0% | 0.037% |  |
| 2/12/2025 | Geode Capital Management LLC | 182,190 | $4.79M | 0.0% | -0.3% | 1.547% |  |
| 2/12/2025 | TLS Advisors LLC | 118,844 | $3.12M | 7.1% | -0.8% | 1.009% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 12,089 | $0.32M | 0.0% | +238.9% | 0.103% |  |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 23,113 | $0.61M | 0.0% | +5.8% | 0.196% |  |
| 2/4/2025 | Los Angeles Capital Management LLC | 7,852 | $0.21M | 0.0% | N/A | 0.067% |  |
| 1/31/2025 | New York State Common Retirement Fund | 2,362 | $62K | 0.0% | +51.2% | 0.020% |  |
| 1/31/2025 | Acuitas Investments LLC | 60,704 | $1.60M | 1.3% | -31.1% | 0.515% |  |
| 1/30/2025 | Rhumbline Advisers | 11,065 | $0.29M | 0.0% | +18.1% | 0.094% |  |
| 11/19/2024 | Barclays PLC | 11,256 | $0.30M | 0.0% | +300.7% | 0.096% |  |
| 11/16/2024 | Geode Capital Management LLC | 182,741 | $4.84M | 0.0% | +0.6% | 1.551% |  |
| 11/15/2024 | Barclays PLC | 11,256 | $0.30M | 0.0% | +300.7% | 0.096% |  |
| 11/15/2024 | State Street Corp | 142,857 | $3.78M | 0.0% | +1.2% | 1.213% |  |
| 11/15/2024 | HighVista Strategies LLC | 114,548 | $3.03M | 1.0% | -3.7% | 0.972% |  |
| 11/14/2024 | Stonepine Capital Management LLC | 195,096 | $5.17M | 3.3% | -22.0% | 1.656% |  |
| 11/13/2024 | BNP Paribas Financial Markets | 1,632 | $43K | 0.0% | +95.0% | 0.014% |  |
| 11/13/2024 | FMR LLC | 1,102,401 | $29.19M | 0.0% | -4.4% | 9.358% |  |
| 10/17/2024 | Ellsworth Advisors LLC | 19,475 | $0.52M | 0.1% | N/A | 0.166% |  |
| 8/21/2024 | Stonepine Capital Management LLC | 250,129 | $5.93M | 5.4% | -1.4% | 2.138% |  |
| 8/9/2024 | Dimensional Fund Advisors LP | 22,414 | $0.53M | 0.0% | -12.2% | 0.193% |  |
| 8/1/2024 | Rhumbline Advisers | 9,695 | $0.23M | 0.0% | +16.0% | 0.083% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 62,656 | $1.48M | 0.0% | +3.2% | 0.538% |  |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 8,778 | $0.21M | 0.0% | N/A | 0.075% |  |
| 5/10/2024 | Vanguard Group Inc. | 405,533 | $9.75M | 0.0% | -3.8% | 3.484% |  |
| 5/1/2024 | BNP Paribas Financial Markets | 3,543 | $85K | 0.0% | +55.6% | 0.030% |  |
| 2/15/2024 | Opaleye Management Inc. | 250,000 | $4.63M | 1.2% | -8.9% | 2.176% |  |
| 2/13/2024 | Stonepine Capital Management LLC | 250,000 | $4.63M | 2.0% | -42.7% | 2.176% |  |
| 11/14/2023 | Stonepine Capital Management LLC | 436,602 | $6.15M | 2.0% | +25.0% | 3.800% |  |
| 9/21/2023 | Barclays PLC | 1,468 | $28K | 0.0% | N/A | 0.013% |  |
| 8/16/2023 | Stonepine Capital Management LLC | 349,399 | $6.60M | 2.4% | +9.8% | 3.045% |  |
| 8/15/2023 | HighVista Strategies LLC | 118,899 | $2.25M | 1.0% | +27.3% | 1.037% |  |
| 8/11/2023 | Stonepine Capital Management LLC | 349,399 | $6.60M | 2.5% | +9.8% | 3.046% |  |
| 8/4/2023 | American International Group Inc. | 3,519 | $66K | 0.0% | N/A | 0.031% |  |
| 5/16/2023 | BVF Inc. IL | 3,633,743 | $76.71M | 2.8% | +0.6% | 31.705% |  |
| 5/15/2023 | Stonepine Capital Management LLC | 318,096 | $6.72M | 2.3% | +393.5% | 2.775% |  |
| 5/11/2023 | Knott David M Jr | 13,527 | $0.29M | 0.1% | +18.4% | 0.118% |  |
| 5/2/2023 | Acuitas Investments LLC | 86,903 | $1.84M | 1.9% | -7.9% | 0.758% |  |
| 2/15/2023 | Eversept Partners LP | 86,873 | $1.60M | 0.1% | -1.7% | 0.759% |  |
| 2/13/2023 | Knott David M Jr | 11,425 | $0.21M | 0.1% | N/A | 0.100% |  |
| 2/10/2023 | Opaleye Management Inc. | 243,000 | $4.47M | 1.6% | -2.0% | 2.122% |  |
| 2/6/2023 | Acuitas Investments LLC | 94,392 | $1.74M | 1.8% | N/A | 0.824% |  |
| 11/15/2022 | First Manhattan Co. | 7,500 | $0.13M | 0.0% | -25.0% | 0.066% |  |
| 11/15/2022 | BVF Inc. IL | 3,611,494 | $64.68M | 2.7% | +2.3% | 31.541% |  |
| 11/14/2022 | Rubric Capital Management LP | 200,785 | $3.60M | 0.2% | +34.4% | 1.753% |  |
| 11/10/2022 | Stonepine Capital Management LLC | 64,459 | $1.15M | 0.5% | +40.4% | 0.563% |  |
| 8/15/2022 | Opaleye Management Inc. | 263,050 | $5.86M | 2.6% | -2.9% | 2.297% |  |
| 8/11/2022 | Trexquant Investment LP | 15,125 | $0.34M | 0.0% | +71.7% | 0.132% |  |
| 8/9/2022 | Lazard Asset Management LLC | 3,379 | $75K | 0.0% | +57.3% | 0.030% |  |
| 4/21/2022 | Strs Ohio | 24,900 | $0.70M | 0.0% | -15.9% | 0.218% |  |
| 2/15/2022 | Stonepine Capital Management LLC | 46,026 | $0.96M | 0.4% | -32.8% | 0.407% |  |
| 2/8/2022 | Northern Trust Corp | 89,447 | $1.86M | 0.0% | -16.8% | 0.791% |  |
| 1/28/2022 | Allspring Global Investments Holdings LLC | 32,639 | $0.68M | 0.0% | N/A | 0.289% |  |
| 11/16/2021 | Opaleye Management Inc. | 338,350 | $8.37M | 1.6% | -1.5% | 2.991% |  |
| 11/15/2021 | Marshall Wace LLP | 9,406 | $0.23M | 0.0% | -34.8% | 0.083% |  |