| 2/17/2025 | Two Sigma Investments LP | 68,555 | $0.22M | 0.0% | +305.2% | 0.278% |  |
| 2/17/2025 | Two Sigma Advisers LP | 61,686 | $0.20M | 0.0% | +95.2% | 0.250% |  |
| 2/17/2025 | Bridgeway Capital Management LLC | 115,400 | $0.36M | 0.0% | +23.7% | 0.467% |  |
| 2/17/2025 | Ally Bridge Group NY LLC | 817,939 | $2.58M | 2.2% | N/A | 3.311% |  |
| 2/17/2025 | Acorn Capital Advisors LLC | 1,147,052 | $3.62M | 2.0% | N/A | 4.644% |  |
| 2/14/2025 | Northern Trust Corp | 91,151 | $0.29M | 0.0% | +33.1% | 0.369% |  |
| 2/14/2025 | QVT Financial LP | 2,313,702 | $7.30M | 0.6% | N/A | 9.367% |  |
| 2/13/2025 | Renaissance Technologies LLC | 456,022 | $1.44M | 0.0% | -1.3% | 1.846% |  |
| 2/12/2025 | Geode Capital Management LLC | 217,294 | $0.69M | 0.0% | +4.1% | 0.880% |  |
| 2/7/2025 | BML Capital Management LLC | 2,100,000 | $6.63M | 4.1% | +5.0% | 8.519% |  |
| 1/29/2025 | Peapod Lane Capital LLC | 442,942 | $1.40M | 1.4% | N/A | 1.797% |  |
| 11/15/2024 | XTX Topco Ltd | 15,591 | $32K | 0.0% | N/A | 0.063% |  |
| 11/15/2024 | Jane Street Group LLC | 25,989 | $54K | 0.0% | -80.6% | 0.105% |  |
| 11/15/2024 | Point72 Asia Singapore Pte. Ltd. | 12,121 | $25K | 0.0% | -51.9% | 0.049% |  |
| 11/5/2024 | BML Capital Management LLC | 2,000,000 | $4.12M | 2.4% | N/A | 8.127% |  |
| 11/5/2024 | GSA Capital Partners LLP | 21,097 | $43K | 0.0% | -23.3% | 0.086% |  |
| 9/16/2024 | Point72 Asia Singapore Pte. Ltd. | 25,176 | $37K | 0.0% | N/A | 0.103% |  |
| 8/15/2024 | Point72 Asia Singapore Pte. Ltd. | 25,176 | $37K | 0.0% | N/A | 0.103% |  |
| 8/9/2024 | Renaissance Technologies LLC | 439,222 | $0.64M | 0.0% | -19.2% | 1.789% |  |
| 8/5/2024 | Acuitas Investments LLC | 352,483 | $0.52M | 0.3% | +10.8% | 1.436% |  |
| 5/7/2024 | Marquette Asset Management LLC | 57,807 | $0.14M | 0.0% | N/A | 0.235% |  |
| 2/12/2024 | Decheng Capital LLC | 526,329 | $1.06M | 0.3% | N/A | 2.146% |  |
| 10/27/2023 | TD Asset Management Inc | 48,166 | $0.23M | 0.0% | +100.0% | 0.196% |  |
| 8/21/2023 | Affinity Asset Advisors LLC | 187,675 | $1.28M | 0.4% | N/A | 0.765% |  |
| 8/14/2023 | Prelude Capital Management LLC | 11,074 | $76K | 0.0% | N/A | 0.045% |  |
| 8/11/2023 | ExodusPoint Capital Management LP | 136,511 | $0.93M | 0.0% | +34.1% | 0.559% |  |
| 8/2/2023 | Bank of Montreal Can | 22,572 | $0.19M | 0.0% | N/A | 0.092% |  |
| 5/16/2023 | BVF Inc. IL | 318,205 | $2.30M | 0.1% | -43.4% | 1.302% |  |
| 5/15/2023 | Ghost Tree Capital LLC | 150,000 | $1.09M | 0.3% | +66.7% | 0.614% |  |
| 5/11/2023 | ExodusPoint Capital Management LP | 101,835 | $0.74M | 0.0% | +35.2% | 0.417% |  |
| 5/11/2023 | Knott David M Jr | 183,688 | $1.33M | 0.5% | +574.3% | 0.752% |  |
| 5/3/2023 | Jump Financial LLC | 20,300 | $0.15M | 0.0% | +91.5% | 0.083% |  |
| 3/23/2023 | MetLife Investment Management LLC | 7,671 | $98K | 0.0% | N/A | 0.031% |  |
| 2/15/2023 | Alerce Investment Management L.P. | 1,630,830 | $20.92M | 24.1% | +26.0% | 6.684% |  |
| 2/13/2023 | Knott David M Jr | 27,242 | $0.35M | 0.1% | -44.4% | 0.112% |  |
| 2/10/2023 | Opaleye Management Inc. | 252,046 | $3.23M | 1.1% | N/A | 1.033% |  |
| 11/14/2022 | Point72 Asset Management L.P. | 567,129 | $8.01M | 0.0% | +4.6% | 2.325% |  |
| 11/14/2022 | RA Capital Management L.P. | 590,218 | $8.34M | 0.2% | +54.1% | 2.419% |  |
| 11/14/2022 | Ghost Tree Capital LLC | 200,000 | $2.83M | 0.8% | +33.3% | 0.820% |  |
| 11/10/2022 | ExodusPoint Capital Management LP | 57,530 | $0.81M | 0.0% | +39.8% | 0.236% |  |
| 11/7/2022 | Jump Financial LLC | 19,300 | $0.27M | 0.0% | N/A | 0.079% |  |
| 10/27/2022 | Strs Ohio | 2,500 | $35K | 0.0% | -26.5% | 0.012% |  |
| 8/15/2022 | Point72 Asset Management L.P. | 542,044 | $6.68M | 0.0% | +156.2% | 2.588% |  |
| 8/15/2022 | Vivo Capital LLC | 509,572 | $6.28M | 0.6% | -34.0% | 2.433% |  |
| 8/12/2022 | Ikarian Capital LLC | 412,343 | $1.27M | 0.2% | +97.9% | 1.969% |  |
| 8/12/2022 | Rafferty Asset Management LLC | 17,839 | $0.22M | 0.0% | -56.2% | 0.085% |  |
| 8/11/2022 | Knott David M Jr | 14,039 | $0.17M | 0.1% | N/A | 0.067% |  |
| 8/11/2022 | Alps Advisors Inc. | 12,423 | $0.15M | 0.0% | -42.1% | 0.059% |  |
| 8/4/2022 | TD Asset Management Inc. | 24,083 | $0.30M | 0.0% | -30.8% | 0.115% |  |
| 7/25/2022 | Strs Ohio | 3,400 | $41K | 0.0% | N/A | 0.016% |  |
| 7/6/2022 | Neville Rodie & Shaw Inc. | 13,333 | $0.16M | 0.0% | N/A | 0.064% |  |
| 5/16/2022 | Eversept Partners LP | 150,817 | $2.56M | 0.2% | N/A | 0.720% |  |
| 5/16/2022 | Ghost Tree Capital LLC | 150,000 | $2.55M | 0.6% | -25.0% | 0.716% |  |
| 5/10/2022 | Decheng Capital Management III Cayman LLC | 526,329 | $8.93M | 2.7% | N/A | 2.513% |  |
| 5/9/2022 | Qube Research & Technologies Ltd | 17,333 | $0.29M | 0.0% | N/A | 0.083% |  |
| 4/26/2022 | Sciencast Management LP | 11,513 | $0.20M | 0.0% | N/A | 0.055% |  |
| 2/16/2022 | Ghost Tree Capital LLC | 200,000 | $4.83M | 1.7% | N/A | 0.957% |  |
| 2/15/2022 | 683 Capital Management LLC | 18,025 | $0.44M | 0.0% | N/A | 0.086% |  |
| 2/11/2022 | Renaissance Technologies LLC | 128,522 | $3.10M | 0.0% | -22.4% | 0.615% |  |
| 2/10/2022 | Rafferty Asset Management LLC | 27,967 | $0.68M | 0.0% | N/A | 0.134% |  |
| 2/10/2022 | Citigroup Inc. | 36,166 | $0.87M | 0.0% | +5,481.2% | 0.173% |  |
| 2/10/2022 | TD Asset Management Inc. | 34,783 | $0.84M | 0.0% | N/A | 0.166% |  |
| 2/9/2022 | Alps Advisors Inc. | 24,174 | $0.58M | 0.0% | N/A | 0.116% |  |
| 2/8/2022 | Northern Trust Corp | 36,808 | $0.89M | 0.0% | N/A | 0.176% |  |
| 1/27/2022 | Ascent Wealth Partners LLC | 10,000 | $0.24M | 0.0% | N/A | 0.048% |  |
| 11/16/2021 | Opaleye Management Inc. | 45,020 | $1.32M | 0.2% | N/A | 1.416% |  |
| 11/16/2021 | VR Adviser LLC | 1,529,402 | $44.92M | 5.8% | N/A | 48.110% |  |
| 11/16/2021 | BVF Inc. IL | 1,147,052 | $33.69M | 1.3% | N/A | 36.082% |  |
| 11/15/2021 | RTW Investments LP | 764,701 | $21.34M | 0.3% | N/A | 24.055% |  |
| 11/15/2021 | Rock Springs Capital Management LP | 764,701 | $22.46M | 0.5% | N/A | 24.055% |  |
| 11/15/2021 | RA Capital Management L.P. | 347,668 | $10.21M | 0.1% | N/A | 10.936% |  |
| 11/12/2021 | Renaissance Technologies LLC | 165,655 | $4.87M | 0.0% | N/A | 5.211% |  |
| 11/10/2021 | US Bancorp DE | 3,333 | $98K | 0.0% | N/A | 0.105% |  |
| 11/9/2021 | BlackRock Inc. | 16,250 | $0.48M | 0.0% | N/A | 0.511% |  |
| 11/2/2021 | Parallel Advisors LLC | 6,408 | $0.19M | 0.0% | N/A | 0.202% |  |
| 8/16/2021 | State Street Corp | 127,850 | $0.22M | 0.0% | N/A | 0.268% |  |