| 5/14/2026 | Renaissance Technologies LLC | 624,367 | $1.72M | 0.0% | -6.7% | 0.614% |  |
| 5/14/2026 | Arrowstreet Capital Limited Partnership | 405,658 | $1.12M | 0.0% | +8.0% | 0.399% |  |
| 5/7/2026 | Dimensional Fund Advisors LP | 390,165 | $1.07M | 0.0% | +82.8% | 0.383% |  |
| 2/18/2026 | Millennium Management LLC | 933,342 | $2.93M | 0.0% | -5.7% | 0.930% |  |
| 2/17/2026 | EFG International AG | 12,900 | $41K | 0.0% | N/A | 0.013% |  |
| 2/13/2026 | Marshall Wace LLP | 186,709 | $0.59M | 0.0% | N/A | 0.186% |  |
| 2/13/2026 | Wells Fargo & Company MN | 1,006,289 | $3.16M | 0.0% | -0.4% | 1.002% |  |
| 2/12/2026 | Renaissance Technologies LLC | 668,867 | $2.10M | 0.0% | -13.2% | 0.666% |  |
| 2/12/2026 | Dimensional Fund Advisors LP | 213,464 | $0.67M | 0.0% | +20.5% | 0.213% |  |
| 2/10/2026 | Goldman Sachs Group Inc. | 18,555 | $58K | 0.0% | +46.9% | 0.018% |  |
| 2/6/2026 | Banque Cantonale Vaudoise | 7,892 | $25K | 0.0% | -57.2% | 0.008% |  |
| 11/17/2025 | Susquehanna International Group LLP | 21,840 | $63K | 0.0% | N/A | 0.022% |  |
| 11/14/2025 | Two Sigma Investments LP | 16,775 | $48K | 0.0% | -45.3% | 0.017% |  |
| 11/13/2025 | Sei Investments Co. | 15,884 | $46K | 0.0% | -36.2% | 0.016% |  |
| 11/13/2025 | Private Advisor Group LLC | 16,600 | $48K | 0.0% | N/A | 0.017% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 177,111 | $0.51M | 0.0% | -10.9% | 0.176% |  |
| 10/7/2025 | Assenagon Asset Management S.A. | 189,892 | $0.55M | 0.0% | N/A | 0.189% |  |
| 8/14/2025 | Sei Investments Co. | 24,897 | $51K | 0.0% | N/A | 0.025% |  |
| 8/13/2025 | Marshall Wace LLP | 135,841 | $0.28M | 0.0% | -36.0% | 0.135% |  |
| 8/12/2025 | Handelsbanken Fonder AB | 105,000 | $0.21M | 0.0% | -19.2% | 0.105% |  |
| 5/21/2025 | Acadian Asset Management LLC | 371,177 | $0.68M | 0.0% | +87.1% | 0.370% |  |
| 5/16/2025 | BVF Inc. IL | 19,822,436 | $37.07M | 1.5% | +1.5% | 19.741% |  |
| 5/8/2025 | Banque Cantonale Vaudoise | 26,712 | $50K | 0.0% | N/A | 0.027% |  |
| 4/15/2025 | Handelsbanken Fonder AB | 130,000 | $0.24M | 0.0% | -13.3% | 0.129% |  |
| 2/17/2025 | Squarepoint Ops LLC | 43,784 | $0.12M | 0.0% | N/A | 0.044% |  |
| 2/17/2025 | Two Sigma Advisers LP | 13,410 | $36K | 0.0% | N/A | 0.014% |  |
| 2/17/2025 | Two Sigma Investments LP | 40,818 | $0.11M | 0.0% | -28.8% | 0.041% |  |
| 2/17/2025 | Redmile Group LLC | 1,034,299 | $2.79M | 0.2% | -38.9% | 1.045% |  |
| 2/17/2025 | Millennium Management LLC | 119,040 | $0.32M | 0.0% | -28.3% | 0.120% |  |
| 2/17/2025 | Cantor Fitzgerald L. P. | 25,000 | $68K | 0.0% | N/A | 0.025% |  |
| 2/14/2025 | Jane Street Group LLC | 24,283 | $66K | 0.0% | N/A | 0.025% |  |
| 2/14/2025 | Northern Trust Corp | 403,031 | $1.09M | 0.0% | N/A | 0.407% |  |
| 2/14/2025 | Boothbay Fund Management LLC | 14,046 | $38K | 0.0% | N/A | 0.014% |  |
| 2/14/2025 | Dimensional Fund Advisors LP | 131,410 | $0.36M | 0.0% | +130.3% | 0.133% |  |
| 2/13/2025 | Marshall Wace LLP | 66,318 | $0.18M | 0.0% | -33.3% | 0.067% |  |
| 2/13/2025 | Quinn Opportunity Partners LLC | 10,100 | $27K | 0.0% | N/A | 0.010% |  |
| 2/13/2025 | Renaissance Technologies LLC | 740,198 | $2M | 0.0% | +14.6% | 0.748% |  |
| 2/13/2025 | Wells Fargo & Company MN | 995,636 | $2.69M | 0.0% | -10.1% | 1.006% |  |
| 2/12/2025 | RPO LLC | 18,728 | $51K | 0.0% | N/A | 0.019% |  |
| 2/12/2025 | Geode Capital Management LLC | 64,090 | $0.17M | 0.0% | +9.9% | 0.065% |  |
| 11/16/2024 | Geode Capital Management LLC | 58,296 | $0.22M | 0.0% | +6.4% | 0.059% |  |
| 11/15/2024 | Redmile Group LLC | 1,694,167 | $6.40M | 0.4% | -6.3% | 1.712% |  |
| 11/8/2024 | Banque Cantonale Vaudoise | 18,562 | $70K | 0.0% | -27.0% | 0.019% |  |
| 10/25/2024 | China Universal Asset Management Co. Ltd. | 19,021 | $72K | 0.0% | +63.7% | 0.019% |  |
| 10/23/2024 | Assenagon Asset Management S.A. | 223,880 | $0.85M | 0.0% | -49.1% | 0.226% |  |
| 9/16/2024 | Cubist Systematic Strategies LLC | 54,610 | $0.22M | 0.0% | N/A | 0.055% |  |
| 8/14/2024 | Cubist Systematic Strategies LLC | 54,610 | $0.22M | 0.0% | N/A | 0.055% |  |
| 8/9/2024 | Renaissance Technologies LLC | 652,079 | $2.60M | 0.0% | +26.4% | 0.659% |  |
| 8/8/2024 | Vanguard Capital Wealth Advisors | 14,000 | $56K | 0.0% | N/A | 0.014% |  |
| 7/31/2024 | Banque Cantonale Vaudoise | 25,418 | $0.10M | 0.0% | -53.0% | 0.026% |  |
| 7/18/2024 | Assenagon Asset Management S.A. | 439,730 | $1.76M | 0.0% | +294.7% | 0.445% |  |
| 7/12/2024 | Silverberg Bernstein Capital Management LLC | 10,000 | $40K | 0.0% | N/A | 0.010% |  |
| 5/16/2024 | Redmile Group LLC | 2,007,031 | $5.94M | 0.2% | +0.4% | 2.029% |  |
| 5/15/2024 | Lazard Asset Management LLC | 10,260 | $30K | 0.0% | N/A | 0.010% |  |
| 5/14/2024 | Platinum Investment Management Ltd. | 1,095,026 | $3.24M | 0.1% | -27.7% | 1.107% |  |
| 5/1/2024 | BNP Paribas Financial Markets | 11,092 | $33K | 0.0% | +315.6% | 0.011% |  |
| 4/29/2024 | China Universal Asset Management Co. Ltd. | 19,008 | $56K | 0.0% | +96.5% | 0.019% |  |
| 2/15/2024 | BVF Inc. IL | 14,571,236 | $72.86M | 1.8% | +96.2% | 17.254% |  |
| 2/14/2024 | Avidity Partners Management LP | 4,469,080 | $22.35M | 0.8% | +50.5% | 5.292% |  |
| 2/14/2024 | Platinum Investment Management Ltd. | 1,515,585 | $7.58M | 0.3% | +14.6% | 1.795% |  |
| 2/9/2024 | Nixon Peabody Trust Co. | 12,850 | $64K | 0.0% | N/A | 0.015% |  |
| 1/24/2024 | China Universal Asset Management Co. Ltd. | 9,674 | $48K | 0.0% | N/A | 0.011% |  |
| 11/14/2023 | Avidity Partners Management LP | 2,969,800 | $8.46M | 0.3% | +2.3% | 3.552% |  |
| 8/11/2023 | Platinum Investment Management Ltd. | 1,322,462 | $3.91M | 0.1% | +22.2% | 1.582% |  |
| 8/9/2023 | Banque Cantonale Vaudoise | 80,701 | $0.24M | 0.0% | +22.6% | 0.097% |  |
| 5/11/2023 | Citigroup Inc. | 870,179 | $2.04M | 0.0% | N/A | 1.041% |  |
| 4/20/2023 | Banque Cantonale Vaudoise | 65,803 | $0.15M | 0.0% | +54.9% | 0.079% |  |
| 4/18/2023 | Assenagon Asset Management S.A. | 111,418 | $0.26M | 0.0% | -81.2% | 0.133% |  |
| 2/15/2023 | Avidity Partners Management LP | 325,400 | $0.66M | 0.0% | +18.4% | 0.389% |  |
| 2/13/2023 | Platinum Investment Management Ltd. | 1,082,462 | $2.21M | 0.1% | +2.2% | 1.296% |  |
| 2/10/2023 | Banque Cantonale Vaudoise | 42,488 | $86K | 0.0% | +92.6% | 0.051% |  |
| 1/12/2023 | Assenagon Asset Management S.A. | 592,044 | $1.21M | 0.0% | N/A | 0.709% |  |
| 11/10/2022 | Kingsbury Capital Investment Advisors LLC | 27,291 | $86K | 0.1% | +44.6% | 0.033% |  |
| 8/11/2022 | Platinum Investment Management Ltd. | 1,059,462 | $3.83M | 0.1% | -0.3% | 1.268% |  |
| 5/16/2022 | Eversept Partners LP | 124,589 | $0.50M | 0.0% | -18.8% | 0.149% |  |
| 5/11/2022 | Handelsbanken Fonder AB | 101,064 | $0.40M | 0.0% | N/A | 0.121% |  |
| 5/9/2022 | Banque Cantonale Vaudoise | 21,617 | $86K | 0.0% | -57.6% | 0.026% |  |
| 2/17/2022 | Metatron Capital SICAV plc | 44,000 | $0.22M | 0.2% | N/A | 0.061% |  |
| 2/14/2022 | Lombard Odier Asset Management Switzerland SA | 348,196 | $1.72M | 0.1% | +9.2% | 0.479% |  |
| 2/14/2022 | Virtus ETF Advisers LLC | 32,852 | $0.16M | 0.1% | +14.5% | 0.045% |  |
| 2/14/2022 | Eversept Partners LP | 153,380 | $0.76M | 0.1% | -30.8% | 0.211% |  |
| 2/14/2022 | GSA Capital Partners LLP | 73,046 | $0.36M | 0.0% | N/A | 0.101% |  |
| 2/8/2022 | ProShare Advisors LLC | 11,230 | $56K | 0.0% | -34.1% | 0.015% |  |