| 5/16/2026 | venBio Partners LLC | 531,337 | $3.42M | 1.2% | -18.1% | 2.149% |  |
| 5/15/2026 | OMERS ADMINISTRATION Corp | 11,400 | $73K | 0.0% | -46.0% | 0.046% |  |
| 5/14/2026 | Renaissance Technologies LLC | 80,038 | $0.52M | 0.0% | -31.1% | 0.324% |  |
| 5/7/2026 | Dimensional Fund Advisors LP | 20,370 | $0.13M | 0.0% | N/A | 0.082% |  |
| 5/5/2026 | Sanctuary Advisors LLC | 21,581 | $0.14M | 0.0% | N/A | 0.087% |  |
| 4/27/2026 | Simplify Asset Management Inc. | 23,230 | $0.15M | 0.0% | N/A | 0.094% |  |
| 2/18/2026 | venBio Partners LLC | 648,507 | $2.78M | 1.3% | -43.6% | 2.642% |  |
| 2/18/2026 | Millennium Management LLC | 217,097 | $0.93M | 0.0% | -17.2% | 0.884% |  |
| 2/16/2026 | OMERS ADMINISTRATION Corp | 21,100 | $91K | 0.0% | N/A | 0.086% |  |
| 2/13/2026 | Marshall Wace LLP | 79,559 | $0.34M | 0.0% | N/A | 0.324% |  |
| 2/13/2026 | State Street Corp | 35,824 | $0.15M | 0.0% | -40.1% | 0.146% |  |
| 2/12/2026 | Jane Street Group LLC | 40,671 | $0.17M | 0.0% | N/A | 0.166% |  |
| 2/12/2026 | Renaissance Technologies LLC | 116,200 | $0.50M | 0.0% | +46.8% | 0.473% |  |
| 2/10/2026 | Goldman Sachs Group Inc. | 12,060 | $52K | 0.0% | -75.8% | 0.049% |  |
| 2/9/2026 | Geode Capital Management LLC | 101,117 | $0.43M | 0.0% | -8.8% | 0.412% |  |
| 11/17/2025 | Qube Research & Technologies Ltd | 25,552 | $73K | 0.0% | -34.0% | 0.104% |  |
| 11/17/2025 | Prelude Capital Management LLC | 14,302 | $41K | 0.0% | N/A | 0.058% |  |
| 11/17/2025 | Millennium Management LLC | 262,160 | $0.75M | 0.0% | -19.8% | 1.068% |  |
| 11/17/2025 | Citadel Advisors LLC | 798,397 | $2.29M | 0.0% | +419.3% | 3.252% |  |
| 11/17/2025 | Bank of America Corp DE | 16,145 | $46K | 0.0% | +225.8% | 0.066% |  |
| 11/13/2025 | Landscape Capital Management L.L.C. | 39,133 | $0.11M | 0.0% | N/A | 0.160% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 118,547 | $0.34M | 0.0% | +14,463.5% | 0.485% |  |
| 8/15/2025 | Bridgeway Capital Management LLC | 35,000 | $53K | 0.0% | N/A | 0.143% |  |
| 8/14/2025 | Jane Street Group LLC | 44,215 | $67K | 0.0% | N/A | 0.181% |  |
| 8/14/2025 | Qube Research & Technologies Ltd | 38,692 | $58K | 0.0% | N/A | 0.158% |  |
| 8/13/2025 | Marshall Wace LLP | 52,213 | $79K | 0.0% | N/A | 0.214% |  |
| 8/8/2025 | Geode Capital Management LLC | 159,041 | $0.24M | 0.0% | -61.3% | 0.653% |  |
| 8/1/2025 | Y Intercept Hong Kong Ltd | 31,567 | $48K | 0.0% | N/A | 0.130% |  |
| 7/31/2025 | Ground Swell Capital LLC | 24,849 | $38K | 0.1% | N/A | 0.102% |  |
| 5/15/2025 | venBio Partners LLC | 1,198,975 | $3.60M | 2.9% | -21.1% | 4.921% |  |
| 5/12/2025 | Nuveen LLC | 47,892 | $0.14M | 0.0% | N/A | 0.197% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 54,881 | $0.17M | 0.0% | +26.1% | 0.225% |  |
| 2/17/2025 | Deutsche Bank AG | 21,423 | $0.22M | 0.0% | N/A | 0.088% |  |
| 2/17/2025 | Bank of America Corp DE | 10,817 | $0.11M | 0.0% | -39.3% | 0.045% |  |
| 2/17/2025 | BNP Paribas Financial Markets | 9,879 | $100K | 0.0% | +262.1% | 0.041% |  |
| 2/14/2025 | Northern Trust Corp | 117,112 | $1.18M | 0.0% | +3.8% | 0.482% |  |
| 2/13/2025 | Barclays PLC | 24,161 | $0.24M | 0.0% | +23.2% | 0.099% |  |
| 2/13/2025 | Wells Fargo & Company MN | 8,616 | $87K | 0.0% | +64.0% | 0.035% |  |
| 2/12/2025 | Geode Capital Management LLC | 315,758 | $3.18M | 0.0% | +2.2% | 1.300% |  |
| 2/12/2025 | Norges Bank | 30,000 | $0.30M | 0.0% | N/A | 0.124% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 37,619 | $0.38M | 0.0% | +250.7% | 0.155% |  |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 43,526 | $0.44M | 0.0% | +8.0% | 0.179% |  |
| 1/30/2025 | Rhumbline Advisers | 12,879 | $0.13M | 0.0% | -13.1% | 0.053% |  |
| 1/24/2025 | China Universal Asset Management Co. Ltd. | 5,150 | $52K | 0.0% | N/A | 0.021% |  |
| 12/26/2024 | JPMorgan Chase & Co. | 10,726 | $0.17M | 0.0% | N/A | 0.044% |  |
| 11/27/2024 | Franklin Resources Inc. | 520,301 | $7.44M | 0.0% | N/A | 2.142% |  |
| 11/19/2024 | Barclays PLC | 19,616 | $0.30M | 0.0% | N/A | 0.081% |  |
| 11/16/2024 | Geode Capital Management LLC | 308,930 | $4.77M | 0.0% | N/A | 1.272% |  |
| 11/15/2024 | Barclays PLC | 19,616 | $0.30M | 0.0% | N/A | 0.081% |  |
| 11/15/2024 | Wellington Management Group LLP | 194,108 | $2.91M | 0.0% | N/A | 0.799% |  |
| 11/15/2024 | State Street Corp | 86,559 | $1.34M | 0.0% | N/A | 0.356% |  |
| 11/15/2024 | Samsara BioCapital LLC | 291,666 | $4.51M | 0.9% | N/A | 1.201% |  |
| 11/15/2024 | RA Capital Management L.P. | 9,853,302 | $152.23M | 1.8% | N/A | 40.565% |  |
| 11/15/2024 | RTW Investments LP | 148,844 | $2.30M | 0.0% | N/A | 0.613% |  |
| 11/14/2024 | Acuta Capital Partners LLC | 44,000 | $0.68M | 0.6% | N/A | 0.181% |  |
| 11/14/2024 | MetLife Investment Management LLC | 8,733 | $0.14M | 0.0% | N/A | 0.036% |  |
| 11/13/2024 | BNP Paribas Financial Markets | 2,728 | $42K | 0.0% | N/A | 0.011% |  |
| 11/12/2024 | Charles Schwab Investment Management Inc. | 40,293 | $0.62M | 0.0% | N/A | 0.166% |  |