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DNLI Insider Trading

Insider Ownership Percentage: 9.70%
Insider Buying (Last 12 Months): $0.00
Insider Selling (Last 12 Months): $936,488.99

Denali Therapeutics Insider Trading History Chart

This chart shows the insider buying and selling history at Denali Therapeutics by year and by quarter.

Skip ChartChart Data in Insider Trading History Table

Denali Therapeutics Share Price & Price History

Current Price: $24.67
Price Change: ▲ Price Increase of +0.1 (0.41%)
As of 08/27/2026 04:00 PM ET

This chart shows the closing price history over time for DNLI up to the past year.

Skip Chart and Table DataPrice Data in Insider Trading History Table
Days: 30 | 90 | 365

Denali Therapeutics Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
8/11/2026Alexander O SchuthInsiderSell2,857$25.07$71,624.99281,763View SEC Filing Icon  
1/6/2026Alexander O SchuthInsiderSell17,218$16.50$284,097.00282,828View SEC Filing Icon  
1/6/2026Ryan J WattsCEOSell35,198$16.50$580,767.00296,833View SEC Filing Icon  
8/13/2025Carole HoInsiderSell806$14.64$11,799.84216,585View SEC Filing Icon  
8/12/2025Alexander O SchuthInsiderSell2,937$13.58$39,884.46242,346View SEC Filing Icon  
8/12/2025Carole HoInsiderSell2,937$13.58$39,884.46217,391View SEC Filing Icon  
7/9/2025Ryan J WattsCEOSell495,282$15.00$7,429,230.00253,071View SEC Filing Icon  
1/7/2025Steve E KrognesDirectorSell3,339$20.81$69,484.5925,757View SEC Filing Icon  
1/6/2025Carole HoInsiderSell12,255$20.22$247,796.10178,580View SEC Filing Icon  
1/6/2025Ryan J WattsCEOSell29,266$20.22$591,758.52260,721View SEC Filing Icon  
1/2/2025Vicki L. SatoDirectorSell3,080$20.91$64,402.80107,976View SEC Filing Icon  
11/7/2024Alexander O SchuthInsiderSell15,558$29.91$465,339.78178,066View SEC Filing Icon  
11/7/2024Vicki L. SatoDirectorSell1,020$30.00$30,600.00111,056View SEC Filing Icon  
10/18/2024Ryan J WattsCEOSell40,000$27.69$1,107,600.00235,807View SEC Filing Icon  
9/30/2024Steve E KrognesDirectorSell30,000$29.03$870,900.0029,096View SEC Filing Icon  
7/1/2024Steve E KrognesDirectorSell30,000$22.12$663,600.0034,404View SEC Filing Icon  
6/13/2024Steve E KrognesDirectorSell688$21.79$14,991.5252,620View SEC Filing Icon  
6/6/2024Jennifer E. CookDirectorSell1,458$21.73$31,682.3420,038View SEC Filing Icon  
4/15/2024Vicki L. SatoDirectorSell1,666$18.29$30,471.14118,043View SEC Filing Icon  
4/1/2024Steve E KrognesDirectorSell92,500$20.50$1,896,250.0047,341View SEC Filing Icon  
2/15/2024Vicki L. SatoDirectorSell1,666$18.37$30,604.42121,375View SEC Filing Icon  
2/13/2024Carole HoInsiderSell2,784$17.29$48,135.36145,010View SEC Filing Icon  
2/13/2024Ryan J WattsCEOSell9,589$17.29$165,793.81238,067View SEC Filing Icon  
2/13/2024Steve E KrognesDirectorSell2,750$17.29$47,547.50139,841View SEC Filing Icon  
1/16/2024Vicki L. SatoDirectorSell1,666$18.42$30,687.72123,041View SEC Filing Icon  
1/10/2024Carole HoInsiderSell4,668$19.02$88,785.36147,794View SEC Filing Icon  
1/9/2024Ryan J WattsCEOSell7,818$19.78$154,640.042,268,363View SEC Filing Icon  
1/5/2024Carole HoInsiderSell9,972$19.43$193,755.96198,777View SEC Filing Icon  
1/5/2024Ryan J WattsCEOSell17,483$19.43$339,694.692,276,181View SEC Filing Icon  
1/5/2024Steve E KrognesDirectorSell3,208$19.43$62,331.44142,591View SEC Filing Icon  
12/15/2023Vicki L. SatoDirectorSell1,666$23.39$38,967.74124,707View SEC Filing Icon  
11/15/2023Vicki L. SatoDirectorSell1,666$19.13$31,870.58126,373View SEC Filing Icon  
10/16/2023Vicki L. SatoDirectorSell1,666$20.66$34,419.56128,039View SEC Filing Icon  
9/15/2023Vicki L. SatoDirectorSell1,666$23.62$39,350.92129,705View SEC Filing Icon  
See Full Table

SEC Filings (Institutional Ownership Changes) for Denali Therapeutics (NASDAQ:DNLI)

92.92% of Denali Therapeutics stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at DNLI by year and by quarter.

Skip Institutional Buying and Selling Chart and Table DataRead Chart Data in Institutional Trading History Table

Denali Therapeutics Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
8/27/2026Corient Private Wealth LP11,704$0.30M0.0%N/A0.007%Search for SEC Filing on Google Icon
8/26/2026HighTower Advisors LLC11,020$0.28M0.0%-7.9%0.007%Search for SEC Filing on Google Icon
8/25/2026VIRGINIA RETIREMENT SYSTEMS ET Al14,300$0.37M0.0%N/A0.009%Search for SEC Filing on Google Icon
8/24/2026California State Teachers Retirement System3,911,652$100.61M0.0%+2,306.0%2.447%Search for SEC Filing on Google Icon
8/21/2026Nykredit A S1,488$38K0.0%N/A0.001%Search for SEC Filing on Google Icon
8/20/2026Alyeska Investment Group L.P.219,334$5.64M0.0%-88.7%0.137%Search for SEC Filing on Google Icon
8/19/2026UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC3,161,972$81.33M0.0%-28.7%1.978%Search for SEC Filing on Google Icon
8/19/2026Wellington Management Group LLP52,618$1.35M0.0%-1.4%0.033%Search for SEC Filing on Google Icon
8/18/2026Empowered Funds LLC14,428$0.37M0.0%N/A0.009%Search for SEC Filing on Google Icon
8/18/2026Jefferies Financial Group Inc.34,425$0.89M0.0%N/A0.022%Search for SEC Filing on Google Icon
8/17/2026Capstone Investment Advisors LLC20,964$0.54M0.0%N/A0.013%Search for SEC Filing on Google Icon
8/17/2026Bank of America Corp DE1,230,957$31.66M0.0%N/A0.770%Search for SEC Filing on Google Icon
8/15/2026Odyssean LLC125,062$3.22M0.5%N/A0.078%Search for SEC Filing on Google Icon
8/15/2026Man Group plc139,065$3.58M0.0%N/A0.087%Search for SEC Filing on Google Icon
8/15/2026Jupiter Topco LLC60,028$1.54M0.0%N/A0.038%Search for SEC Filing on Google Icon
8/14/2026ADAR1 Capital Management LLC1,029,080$26.47M1.2%N/A0.644%Search for SEC Filing on Google Icon
8/14/2026Legal & General Group Plc111,953$2.88M0.0%N/A0.070%Search for SEC Filing on Google Icon
8/14/2026The Manufacturers Life Insurance Company 117,348$3.02M0.0%N/A0.073%Search for SEC Filing on Google Icon
8/13/2026Connor Clark & Lunn Investment Management Ltd.18,556$0.48M0.0%N/A0.012%Search for SEC Filing on Google Icon
8/12/2026Elevation Point Wealth Partners LLC8,343$0.22M0.0%N/A0.005%Search for SEC Filing on Google Icon
8/12/2026Ieq Capital LLC20,185$0.52M0.0%N/A0.013%Search for SEC Filing on Google Icon
8/11/2026Allworth Financial LP1,834$47K0.0%N/A0.001%Search for SEC Filing on Google Icon
8/11/2026B. Metzler seel. Sohn & Co. AG112,300$2.89M0.0%N/A0.071%Search for SEC Filing on Google Icon
8/11/2026E Fund Management Co. Ltd.13,585$0.35M0.0%N/A0.009%Search for SEC Filing on Google Icon
8/11/2026Edmond DE Rothschild Holding S.A.165,080$4.25M0.1%N/A0.104%Search for SEC Filing on Google Icon
8/10/2026Great Lakes Advisors LLC145,045$3.73M0.0%N/A0.091%Search for SEC Filing on Google Icon
8/7/2026BlackRock Inc.14,026,413$360.76M0.0%N/A8.838%Search for SEC Filing on Google Icon
8/7/2026Deutsche Bank AG149,804$3.85M0.0%N/A0.094%Search for SEC Filing on Google Icon
8/7/2026Mitsubishi UFJ Asset Management Co. Ltd.1,001$26K0.0%N/A0.001%Search for SEC Filing on Google Icon
8/6/2026Global Retirement Partners LLC1,103$28K0.0%N/A0.001%Search for SEC Filing on Google Icon
8/6/2026SCS Capital Management LLC197,998$5.09M0.0%N/A0.125%Search for SEC Filing on Google Icon
8/6/2026Bank of New York Mellon Corp800,283$20.58M0.0%N/A0.504%Search for SEC Filing on Google Icon
8/6/2026State of Wyoming17,778$0.46M0.0%N/A0.011%Search for SEC Filing on Google Icon
7/10/2026E. Ohman J or Asset Management AB160,000$4.12M0.1%N/A0.101%Search for SEC Filing on Google Icon
7/10/2026Handelsbanken Fonder AB59,600$1.53M0.0%+36.1%0.038%Search for SEC Filing on Google Icon
6/12/2026Defilade Capital Management L.P.1,359,969$26.11M3.7%+107.1%0.857%Search for SEC Filing on Google Icon
6/4/2026Seven Fleet Capital Management LP35,286$0.68M0.2%N/A0.022%Search for SEC Filing on Google Icon
5/22/2026Groupama Asset Managment207,130$3.98M0.1%+36.6%0.131%Search for SEC Filing on Google Icon
5/22/2026Segall Bryant & Hamill LLC510,543$9.80M0.1%-4.9%0.322%Search for SEC Filing on Google Icon
5/19/2026Bank of America Corp DE1,134,183$21.78M0.0%+21.7%0.715%Search for SEC Filing on Google Icon
5/19/2026Stempoint Capital LP426,561$8.19M1.6%+1.8%0.269%Search for SEC Filing on Google Icon
5/18/2026ADAR1 Capital Management LLC1,871,455$35.93M2.1%+3,490.9%1.179%Search for SEC Filing on Google Icon
5/18/2026Amundi18,604$0.36M0.0%N/A0.012%Search for SEC Filing on Google Icon
5/18/2026California State Teachers Retirement System162,576$3.12M0.0%+25.6%0.102%Search for SEC Filing on Google Icon
5/18/2026Royal Bank of Canada7,535$0.15M0.0%-33.5%0.005%Search for SEC Filing on Google Icon
5/18/2026Empowered Funds LLC15,787$0.30M0.0%+39.4%0.010%Search for SEC Filing on Google Icon
5/16/2026The Manufacturers Life Insurance Company125,442$2.41M0.0%-31.9%0.079%Search for SEC Filing on Google Icon
5/16/2026Quantinno Capital Management LP30,170$0.58M0.0%+14.7%0.019%Search for SEC Filing on Google Icon
5/16/2026Masters Capital Management LLC600,000$11.52M0.4%-40.0%0.378%Search for SEC Filing on Google Icon
5/14/2026Sei Investments Co.52,235$1M0.0%N/A0.033%Search for SEC Filing on Google Icon
5/13/2026Cetera Investment Advisers11,059$0.21M0.0%N/A0.007%Search for SEC Filing on Google Icon
5/8/2026PNC Financial Services Group Inc.9,220$0.18M0.0%+8.7%0.006%Search for SEC Filing on Google Icon
5/7/2026Dimensional Fund Advisors LP2,692,175$51.69M0.0%+13.4%1.697%Search for SEC Filing on Google Icon
5/7/2026KBC Group NV4,943$95K0.0%-21.1%0.003%Search for SEC Filing on Google Icon
5/5/2026D.A. Davidson & CO.110,235$2.12M0.0%+3.1%0.069%Search for SEC Filing on Google Icon
5/5/2026Bank of New York Mellon Corp768,039$14.75M0.0%+0.8%0.484%Search for SEC Filing on Google Icon
5/4/2026Principal Financial Group Inc.1,478,486$28.39M0.0%-3.0%0.932%Search for SEC Filing on Google Icon
5/4/2026Teachers Retirement System of The State of Kentucky166,181$3.19M0.0%+8.1%0.105%Search for SEC Filing on Google Icon
5/1/2026Fifth Third Bancorp2,847$55K0.0%N/A0.002%Search for SEC Filing on Google Icon
5/1/2026Candriam S.C.A.1,099,845$21.12M0.1%-5.7%0.693%Search for SEC Filing on Google Icon
4/27/2026Y Intercept Hong Kong Ltd78,007$1.50M0.0%-16.6%0.049%Search for SEC Filing on Google Icon
4/22/2026Pictet Asset Management Holding SA2,558,865$48.44M0.1%+92.5%1.614%Search for SEC Filing on Google Icon
4/22/2026Sterling Capital Management LLC4,493$86K0.0%-37.9%0.003%Search for SEC Filing on Google Icon
4/21/2026Contravisory Investment Management Inc.14,451$0.28M0.1%N/A0.009%Search for SEC Filing on Google Icon
4/20/2026Breakwater Capital Group15,586$0.30M0.0%-4.8%0.010%Search for SEC Filing on Google Icon
4/16/2026SG Americas Securities LLC46,642$0.90M0.0%-68.8%0.029%Search for SEC Filing on Google Icon
2/27/2026Groupama Asset Managment151,591$2.50M0.0%+11.7%0.103%Search for SEC Filing on Google Icon
2/19/2026T. Rowe Price Investment Management Inc.7,254,132$119.77M0.1%+28.7%4.946%Search for SEC Filing on Google Icon
2/19/2026Invesco Ltd.291,936$4.82M0.0%+17.0%0.199%Search for SEC Filing on Google Icon
2/18/2026Voloridge Investment Management LLC591,461$9.77M0.0%-36.8%0.403%Search for SEC Filing on Google Icon
2/18/2026Vestal Point Capital LP465,000$7.68M0.3%N/A0.317%Search for SEC Filing on Google Icon
2/18/2026Virtus Investment Advisers LLC14,795$0.24M0.1%+94.1%0.010%Search for SEC Filing on Google Icon
2/18/2026Wellington Management Group LLP54,543$0.90M0.0%-7.9%0.037%Search for SEC Filing on Google Icon
2/18/2026Susquehanna Portfolio Strategies LLC167,713$2.77M0.0%N/A0.114%Search for SEC Filing on Google Icon
2/18/2026Tudor Investment Corp ET AL53,683$0.89M0.0%-4.8%0.037%Search for SEC Filing on Google Icon
2/18/2026Millennium Management LLC369,767$6.11M0.0%-71.7%0.252%Search for SEC Filing on Google Icon
2/18/2026Man Group plc48,994$0.81M0.0%N/A0.033%Search for SEC Filing on Google Icon
2/18/2026Ishara Investments LP70,000$1.16M1.3%N/A0.048%Search for SEC Filing on Google Icon
2/18/2026Casdin Capital LLC1,840,000$30.38M1.9%+106.7%1.255%Search for SEC Filing on Google Icon
2/18/2026Clough Capital Partners L P51,830$0.86M0.1%N/A0.035%Search for SEC Filing on Google Icon
2/17/2026Guggenheim Capital LLC12,468$0.21M0.0%-74.8%0.009%Search for SEC Filing on Google Icon
2/17/2026ADAR1 Capital Management LLC52,116$0.86M0.1%+1.2%0.036%Search for SEC Filing on Google Icon
2/17/2026Burkehill Global Management LP200,000$3.30M0.2%N/A0.136%Search for SEC Filing on Google Icon
2/17/2026AQR Capital Management LLC38,438$0.64M0.0%+59.2%0.026%Search for SEC Filing on Google Icon
2/17/2026Trexquant Investment LP209,609$3.46M0.0%-51.3%0.143%Search for SEC Filing on Google Icon
2/17/2026Jump Financial LLC40,608$0.67M0.0%-75.6%0.028%Search for SEC Filing on Google Icon
2/17/2026Price T Rowe Associates Inc. MD3,915,951$64.65M0.0%-14.3%2.670%Search for SEC Filing on Google Icon
2/17/2026T. Rowe Price Investment Management Inc.1,245,994$20.57M0.0%-77.9%0.850%Search for SEC Filing on Google Icon
2/17/2026Ghisallo Capital Management LLC100,000$1.65M0.1%N/A0.068%Search for SEC Filing on Google Icon
2/17/2026State of Wisconsin Investment Board73,581$1.22M0.0%-8.2%0.050%Search for SEC Filing on Google Icon
2/17/2026ExodusPoint Capital Management LP1,023,253$16.89M0.1%N/A0.698%Search for SEC Filing on Google Icon
2/17/2026Royal Bank of Canada11,335$0.19M0.0%-97.0%0.008%Search for SEC Filing on Google Icon
2/17/2026Graham Capital Management L.P.18,121$0.30M0.0%-53.9%0.012%Search for SEC Filing on Google Icon
2/17/2026Persistent Asset Partners Ltd5,670$94K0.0%N/A0.004%Search for SEC Filing on Google Icon
2/17/2026Aster Capital Management DIFC Ltd3,451$57K0.0%N/A0.002%Search for SEC Filing on Google Icon
2/17/2026Temasek Holdings Private Ltd7,012,974$115.78M0.4%+30.9%4.782%Search for SEC Filing on Google Icon
2/16/2026Barclays PLC407,359$6.73M0.0%-6.8%0.278%Search for SEC Filing on Google Icon
2/13/2026Marshall Wace LLP763,892$12.61M0.0%-2.9%0.521%Search for SEC Filing on Google Icon
2/13/2026The Manufacturers Life Insurance Company 184,238$3.03M0.0%-10.5%0.126%Search for SEC Filing on Google Icon
2/13/2026Segall Bryant & Hamill LLC537,000$8.87M0.1%+4.7%0.366%Search for SEC Filing on Google Icon
Data available starting January 2016

See Full Table
Denali Therapeutics logo
Denali Therapeutics Inc., a biopharmaceutical company, develops a portfolio of product candidates engineered to cross the blood-brain barrier for neurodegenerative diseases and lysosomal storage diseases in the United States. The company's transport vehicle (TV)-enabled programs include DNL310 ETV, an IDS enzyme replacement therapy program for MPS II; TAK-594/DNL593 which is in Phase 1/II for frontotemporal dementia-granulin; DNL126 program for MPS IIIA; and DNL622 for MPS I, as well as other preclinical programs that target amyloid beta and HER2. Its brain-penetrant small molecule programs comprise BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; SAR443820/DNL788 RIPK1 inhibitor program for CNS disease; DNL343 eIF2B Activator program for amyotrophic lateral sclerosis; and SAR443122/DNL758 RIPK1 inhibitor program for peripheral inflammatory diseases. It also provides early stage program include TAK-594/DNL593 program for FTD-GRN; DNL126 program for MPS IIIA, a Sanfilippo Syndrome A; DNL622 for MPS I which is Hurler syndrome; Antibody Transport Vehicle Amyloid beta program; Oligonucleotide Transport Vehicle platform, a novel class of biotherapeutics to address the root cause of diseases through modulation of gene expression; and other TV-enabled discovery programs. The company has collaboration agreements with Biogen MA Inc. and Biogen International GmbH; Genzyme Corporation; Takeda Pharmaceutical Company Limited; F-star Gamma Limited, F-star Biotechnologische Forschungs-und Entwicklungsges m.b.H, and F-star Biotechnology Limited; and Genentech, Inc. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.
Read More on Denali Therapeutics

Today's Range

Now: $24.67
Low: $24.16
High: $24.74

50 Day Range

MA: $24.60
Low: $22.65
High: $27.21

52 Week Range

Now: $24.67
Low: $12.58
High: $27.30

Volume

700,064 shs

Average Volume

1,261,230 shs

Market Capitalization

$3.94 billion

P/E Ratio

N/A

Dividend Yield

N/A

Beta

1.01

Who are the company insiders with the largest holdings of Denali Therapeutics?

Denali Therapeutics' top insider investors include:
  1. Marc Tessier-Lavigne (Director)
  2. Ryan J Watts (CEO)
  3. Steve E Krognes (CFO)
  4. Alexander O Schuth (Insider)
  5. Carole Ho (Insider)
  6. Steve E Krognes (Director)
  7. Vicki L Sato (Director)
  8. David P Schenkein (Director)
  9. Alexander O Schuth (COO)
  10. Jennifer E Cook (Director)
Learn More about top insider investors at Denali Therapeutics.

Who are the major institutional investors of Denali Therapeutics?

Denali Therapeutics' top institutional shareholders include:
  1. BlackRock Inc. — 8.84%
  2. California State Teachers Retirement System — 2.45%
  3. UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC — 1.98%
  4. Bank of America Corp DE — 0.77%
  5. ADAR1 Capital Management LLC — 0.64%
  6. Bank of New York Mellon Corp — 0.50%
Learn More about top institutional investors of Denali Therapeutics stock.

Which major investors are selling Denali Therapeutics stock?

Within the previous quarter, DNLI stock was sold by these institutional investors:
  1. Alyeska Investment Group L.P.
  2. UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC
  3. HighTower Advisors LLC
  4. Wellington Management Group LLP
During the last year, company insiders that have sold Denali Therapeutics company stock include:
  1. Ryan J Watts (CEO)
  2. Alexander O Schuth (Insider)
Learn More investors selling Denali Therapeutics stock.

Which major investors are buying Denali Therapeutics stock?

Within the last quarter, DNLI stock was purchased by institutional investors including:
  1. BlackRock Inc.
  2. California State Teachers Retirement System
  3. Bank of America Corp DE
  4. ADAR1 Capital Management LLC
  5. Bank of New York Mellon Corp
  6. SCS Capital Management LLC
  7. Edmond DE Rothschild Holding S.A.
  8. E. Ohman J or Asset Management AB

Denali Therapeutics Active Insiders

Ryan J. Watts
Ryan J. Watts (Age 50)
CEO
Alexander O. Schuth
Alexander O. Schuth (Age 52)
COO
1 recent trades
Steve E. Krognes
Steve E. Krognes (Age 57)
CFO
Vicki L Sato
Vicki L Sato
Director
Marc Tessier-Lavigne
Marc Tessier-Lavigne (Age 66)
Director
David P Schenkein
David P Schenkein
Director
Jennifer E Cook
Jennifer E Cook
Director
Carole Ho
Carole Ho (Age 53)
Insider