| 11/21/2025 | CIBC Bancorp USA Inc. | 18,504 | $40K | 0.0% | N/A | 0.007% |  |
| 11/17/2025 | Woodline Partners LP | 1,534,390 | $3.35M | 0.0% | -26.0% | 0.541% |  |
| 11/17/2025 | Vivo Capital LLC | 9,273,428 | $20.22M | 1.6% | +37.2% | 3.269% |  |
| 11/17/2025 | Paradigm Biocapital Advisors LP | 13,560,017 | $29.56M | 0.8% | +13.9% | 4.780% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 81,534 | $0.18M | 0.0% | -14.2% | 0.029% |  |
| 11/17/2025 | Brevan Howard Capital Management LP | 90,746 | $0.20M | 0.0% | -26.0% | 0.032% |  |
| 11/17/2025 | Bank of America Corp DE | 1,534,274 | $3.35M | 0.0% | -2.4% | 0.541% |  |
| 11/14/2025 | Creative Planning | 350,314 | $0.76M | 0.0% | +43.4% | 0.123% |  |
| 11/14/2025 | Qtron Investments LLC | 33,593 | $73K | 0.0% | +219.9% | 0.012% |  |
| 11/14/2025 | Two Sigma Investments LP | 347,767 | $0.76M | 0.0% | -18.7% | 0.123% |  |
| 11/14/2025 | Squarepoint Ops LLC | 84,701 | $0.19M | 0.0% | N/A | 0.030% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 38,161 | $83K | 0.0% | +76.8% | 0.013% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 14,378 | $31K | 0.0% | N/A | 0.005% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 1,371,935 | $2.99M | 0.0% | -19.0% | 0.484% |  |
| 11/12/2025 | Intech Investment Management LLC | 79,975 | $0.17M | 0.0% | -39.5% | 0.028% |  |
| 11/10/2025 | China Universal Asset Management Co. Ltd. | 49,723 | $0.11M | 0.0% | -12.6% | 0.018% |  |
| 11/7/2025 | GSA Capital Partners LLP | 62,678 | $0.14M | 0.0% | -49.1% | 0.022% |  |
| 11/7/2025 | Vanguard Group Inc. | 12,811,832 | $27.93M | 0.0% | +0.9% | 4.516% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 1,269,042 | $2.77M | 0.0% | -7.5% | 0.447% |  |
| 11/6/2025 | ProShare Advisors LLC | 39,786 | $87K | 0.0% | -13.8% | 0.014% |  |
| 11/5/2025 | Alps Advisors Inc. | 132,499 | $0.29M | 0.0% | -13.3% | 0.047% |  |
| 11/5/2025 | Savant Capital LLC | 63,754 | $0.14M | 0.0% | -6.5% | 0.022% |  |
| 11/3/2025 | New York State Common Retirement Fund | 60,452 | $0.13M | 0.0% | +61.8% | 0.021% |  |
| 10/23/2025 | SG Americas Securities LLC | 14,605 | $32K | 0.0% | N/A | 0.005% |  |
| 10/21/2025 | Crowley Wealth Management Inc. | 15,000 | $33K | 0.0% | N/A | 0.005% |  |
| 10/15/2025 | CWM LLC | 33,300 | $73K | 0.0% | -19.0% | 0.012% |  |
| 10/9/2025 | Voya Investment Management LLC | 33,187 | $72K | 0.0% | -36.6% | 0.012% |  |
| 8/15/2025 | Captrust Financial Advisors | 54,111 | $69K | 0.0% | +13.6% | 0.019% |  |
| 8/15/2025 | Octagon Capital Advisors LP | 700,000 | $0.89M | 0.2% | -86.4% | 0.247% |  |
| 8/15/2025 | Frazier Life Sciences Management L.P. | 22,729,436 | $28.87M | 1.2% | +0.7% | 8.013% |  |
| 8/15/2025 | EP Wealth Advisors LLC | 23,000 | $29K | 0.0% | N/A | 0.008% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 21,579 | $27K | 0.0% | +58.0% | 0.008% |  |
| 8/15/2025 | Brevan Howard Capital Management LP | 122,671 | $0.16M | 0.0% | N/A | 0.043% |  |
| 8/15/2025 | Bank of America Corp DE | 1,571,325 | $2M | 0.0% | -19.4% | 0.554% |  |
| 8/14/2025 | Jane Street Group LLC | 132,269 | $0.17M | 0.0% | N/A | 0.047% |  |
| 8/14/2025 | VR Adviser LLC | 17,857,083 | $22.68M | 1.7% | +10.1% | 6.304% |  |
| 8/14/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 94,986 | $0.12M | 0.0% | -12.7% | 0.034% |  |
| 8/14/2025 | Velan Capital Investment Management LP | 65,000 | $83K | 0.1% | +30.0% | 0.023% |  |
| 8/14/2025 | Cerity Partners LLC | 57,817 | $73K | 0.0% | +62.8% | 0.020% |  |
| 8/13/2025 | Affinity Asset Advisors LLC | 4,085,787 | $5.19M | 0.7% | +22.3% | 1.442% |  |
| 8/13/2025 | Marshall Wace LLP | 2,074,425 | $2.64M | 0.0% | +2.3% | 0.732% |  |
| 8/13/2025 | Invesco Ltd. | 172,226 | $0.22M | 0.0% | +51.6% | 0.061% |  |
| 8/13/2025 | Sio Capital Management LLC | 1,369,748 | $1.74M | 0.7% | +1.0% | 0.484% |  |
| 8/13/2025 | Panagora Asset Management Inc. | 49,606 | $63K | 0.0% | N/A | 0.018% |  |
| 8/13/2025 | New York State Common Retirement Fund | 37,360 | $47K | 0.0% | +39.1% | 0.013% |  |
| 8/12/2025 | XTX Topco Ltd | 106,779 | $0.14M | 0.0% | -13.5% | 0.038% |  |
| 8/12/2025 | Rhumbline Advisers | 201,516 | $0.26M | 0.0% | -3.8% | 0.071% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 1,372,569 | $1.74M | 0.0% | -3.0% | 0.485% |  |
| 8/12/2025 | Dynamic Technology Lab Private Ltd | 29,177 | $37K | 0.0% | +180.8% | 0.010% |  |
| 8/8/2025 | Creative Planning | 244,332 | $0.31M | 0.0% | +423.3% | 0.086% |  |
| 8/8/2025 | Geode Capital Management LLC | 4,835,642 | $6.14M | 0.0% | +1.6% | 1.707% |  |
| 8/7/2025 | Los Angeles Capital Management LLC | 35,075 | $45K | 0.0% | N/A | 0.012% |  |
| 8/6/2025 | Savant Capital LLC | 68,221 | $87K | 0.0% | N/A | 0.024% |  |
| 7/25/2025 | Vanguard Personalized Indexing Management LLC | 36,362 | $46K | 0.0% | +130.1% | 0.013% |  |
| 7/15/2025 | Palumbo Wealth Management LLC | 120,466 | $0.15M | 0.0% | +178.0% | 0.043% |  |
| 7/10/2025 | Wealth Enhancement Advisory Services LLC | 21,349 | $27K | 0.0% | -24.1% | 0.008% |  |
| 5/29/2025 | Rhumbline Advisers | 209,443 | $0.29M | 0.0% | -6.5% | 0.074% |  |
| 5/23/2025 | Siren L.L.C. | 8,757,249 | $12M | 0.7% | -1.1% | 3.091% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 1,936,257 | $2.65M | 0.0% | -30.9% | 0.683% |  |
| 5/16/2025 | Millennium Management LLC | 3,224,518 | $4.42M | 0.0% | -22.8% | 1.138% |  |
| 5/16/2025 | AQR Capital Management LLC | 396,202 | $0.54M | 0.0% | +594.8% | 0.140% |  |
| 5/15/2025 | Frazier Life Sciences Management L.P. | 22,575,851 | $30.93M | 1.4% | +16.4% | 7.969% |  |
| 5/15/2025 | Paradigm Biocapital Advisors LP | 10,802,354 | $14.80M | 0.7% | +0.5% | 3.813% |  |
| 5/15/2025 | DAFNA Capital Management LLC | 340,000 | $0.47M | 0.1% | N/A | 0.120% |  |
| 5/15/2025 | Velan Capital Investment Management LP | 50,000 | $68K | 0.1% | N/A | 0.018% |  |
| 5/15/2025 | Siren L.L.C. | 8,757,249 | $12M | 0.7% | -1.1% | 3.091% |  |
| 5/14/2025 | Affinity Asset Advisors LLC | 3,341,519 | $4.58M | 0.4% | +33.7% | 1.180% |  |
| 5/14/2025 | MetLife Investment Management LLC | 93,594 | $0.13M | 0.0% | -17.0% | 0.033% |  |
| 5/14/2025 | Walleye Capital LLC | 215,220 | $0.30M | 0.0% | +55.2% | 0.076% |  |
| 5/14/2025 | T. Rowe Price Investment Management Inc. | 17,292,164 | $23.69M | 0.0% | +3.5% | 6.104% |  |
| 5/14/2025 | Wellington Management Group LLP | 850,147 | $1.17M | 0.0% | +82.6% | 0.300% |  |
| 5/13/2025 | American Century Companies Inc. | 158,081 | $0.22M | 0.0% | -56.5% | 0.056% |  |
| 5/12/2025 | Nuveen LLC | 483,583 | $0.66M | 0.0% | N/A | 0.171% |  |
| 5/12/2025 | Invesco Ltd. | 113,583 | $0.16M | 0.0% | +133.4% | 0.040% |  |
| 5/12/2025 | Swiss National Bank | 328,700 | $0.45M | 0.0% | -9.0% | 0.116% |  |
| 5/9/2025 | Deutsche Bank AG | 163,052 | $0.22M | 0.0% | +20.1% | 0.058% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 1,441,656 | $1.98M | 0.0% | -18.2% | 0.509% |  |
| 5/9/2025 | IPG Investment Advisors LLC | 248,108 | $0.34M | 0.1% | +46.0% | 0.088% |  |
| 5/8/2025 | XTX Topco Ltd | 123,501 | $0.17M | 0.0% | +123.1% | 0.044% |  |
| 5/7/2025 | TD Asset Management Inc | 256,032 | $0.35M | 0.0% | +6.3% | 0.090% |  |
| 5/6/2025 | Y Intercept Hong Kong Ltd | 98,961 | $0.14M | 0.0% | N/A | 0.035% |  |
| 5/1/2025 | CWM LLC | 36,250 | $50K | 0.0% | +1,907.2% | 0.013% |  |
| 4/30/2025 | Cerity Partners LLC | 35,504 | $49K | 0.0% | N/A | 0.013% |  |
| 4/30/2025 | Alps Advisors Inc. | 210,283 | $0.29M | 0.0% | -8.0% | 0.074% |  |
| 4/28/2025 | Teacher Retirement System of Texas | 45,790 | $63K | 0.0% | -16.3% | 0.016% |  |
| 4/28/2025 | Aaron Wealth Advisors LLC | 54,658 | $75K | 0.0% | +97.1% | 0.019% |  |
| 4/22/2025 | Palumbo Wealth Management LLC | 43,331 | $59K | 0.0% | +51.5% | 0.015% |  |
| 4/17/2025 | Exchange Traded Concepts LLC | 87,251 | $0.12M | 0.0% | +46.9% | 0.031% |  |
| 4/16/2025 | Wealth Enhancement Advisory Services LLC | 28,139 | $39K | 0.0% | N/A | 0.010% |  |
| 4/8/2025 | Rhumbline Advisers | 209,443 | $0.29M | 0.0% | -6.5% | 0.074% |  |
| 3/24/2025 | Wellington Management Group LLP | 465,672 | $1.17M | 0.0% | N/A | 0.165% |  |
| 3/18/2025 | California State Teachers Retirement System | 171,821 | $0.43M | 0.0% | +7.1% | 0.061% |  |
| 2/20/2025 | Mackenzie Financial Corp | 11,141 | $28K | 0.0% | N/A | 0.004% |  |
| 2/17/2025 | UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 444,769 | $1.12M | 0.0% | +22.2% | 0.157% |  |
| 2/17/2025 | Woodline Partners LP | 4,147,275 | $10.41M | 0.1% | +0.2% | 1.467% |  |
| 2/17/2025 | Squarepoint Ops LLC | 50,308 | $0.13M | 0.0% | N/A | 0.018% |  |
| 2/17/2025 | Two Sigma Advisers LP | 594,600 | $1.49M | 0.0% | -25.0% | 0.210% |  |
| 2/17/2025 | Two Sigma Investments LP | 958,245 | $2.41M | 0.0% | -28.8% | 0.339% |  |
| 2/17/2025 | Tang Capital Management LLC | 602,915 | $1.51M | 0.1% | +19.9% | 0.213% |  |
| 2/17/2025 | Suvretta Capital Management LLC | 12,315,004 | $30.91M | 1.1% | -10.6% | 4.356% |  |