| 8/27/2026 | Corient Private Wealth LP | 117,377 | $2.15M | 0.0% | N/A | 0.034% |  |
| 8/25/2026 | VIRGINIA RETIREMENT SYSTEMS ET Al | 10,400 | $0.19M | 0.0% | N/A | 0.003% |  |
| 8/24/2026 | California State Teachers Retirement System | 3,229,321 | $59.16M | 0.0% | +1,479.5% | 0.923% |  |
| 8/23/2026 | Frazier Life Sciences Management L.P. | 24,975,188 | $457.55M | 10.0% | +1.2% | 7.141% |  |
| 8/22/2026 | AlphaGrep UK Ltd | 20,340 | $0.37M | 0.1% | N/A | 0.006% |  |
| 8/21/2026 | AXQ Capital LP | 63,443 | $1.16M | 0.1% | N/A | 0.018% |  |
| 8/21/2026 | Nykredit A S | 1,579 | $29K | 0.0% | N/A | 0.000% |  |
| 8/19/2026 | UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 266,140 | $4.88M | 0.0% | +2.8% | 0.076% |  |
| 8/19/2026 | Wellington Management Group LLP | 655,298 | $12.01M | 0.0% | +10.1% | 0.187% |  |
| 8/17/2026 | Seven Fleet Capital Management LP | 308,007 | $5.64M | 0.9% | +38.5% | 0.088% |  |
| 8/17/2026 | Corient Private Wealth LP | 117,377 | $2.15M | 0.0% | N/A | 0.034% |  |
| 8/17/2026 | Bank of America Corp DE | 3,048,737 | $55.85M | 0.0% | N/A | 0.872% |  |
| 8/15/2026 | Odyssean LLC | 34,780 | $0.64M | 0.1% | +100.7% | 0.010% |  |
| 8/15/2026 | Man Group plc | 202,553 | $3.71M | 0.0% | N/A | 0.058% |  |
| 8/15/2026 | Jupiter Topco LLC | 76,600 | $1.40M | 0.0% | N/A | 0.022% |  |
| 8/15/2026 | ARCH Venture Management LLC | 7,091,557 | $129.92M | 0.0% | N/A | 2.028% |  |
| 8/14/2026 | Parkman Healthcare Partners LLC | 258,684 | $4.74M | 0.5% | N/A | 0.074% |  |
| 8/14/2026 | Legal & General Group Plc | 148,195 | $2.72M | 0.0% | N/A | 0.042% |  |
| 8/14/2026 | The Manufacturers Life Insurance Company | 347,656 | $6.37M | 0.0% | N/A | 0.099% |  |
| 8/14/2026 | Spruce Street Capital LP | 422,543 | $7.74M | 0.0% | N/A | 0.121% |  |
| 8/14/2026 | Algert Global LLC | 31,640 | $0.58M | 0.0% | -64.1% | 0.009% |  |
| 8/13/2026 | Sanctuary Advisors LLC | 11,599 | $0.21M | 0.0% | N/A | 0.004% |  |
| 8/13/2026 | Polymer Capital Management HK LTD | 478,020 | $8.76M | 0.4% | N/A | 0.154% |  |
| 8/12/2026 | Quantbot Technologies LP | 5,806 | $0.11M | 0.0% | N/A | 0.002% |  |
| 8/11/2026 | Allworth Financial LP | 1,836 | $34K | 0.0% | N/A | 0.001% |  |
| 8/11/2026 | E Fund Management Co. Ltd. | 265,381 | $4.86M | 0.1% | N/A | 0.085% |  |
| 8/7/2026 | BlackRock Inc. | 21,154,146 | $387.54M | 0.0% | N/A | 6.802% |  |
| 8/7/2026 | Pallas Capital Advisors LLC | 12,129 | $0.22M | 0.0% | N/A | 0.004% |  |
| 8/7/2026 | Deutsche Bank AG | 222,306 | $4.07M | 0.0% | N/A | 0.071% |  |
| 8/7/2026 | Mitsubishi UFJ Asset Management Co. Ltd. | 41,000 | $0.75M | 0.0% | N/A | 0.013% |  |
| 8/7/2026 | Persistent Asset Partners Ltd | 20,573 | $0.38M | 0.1% | N/A | 0.007% |  |
| 8/6/2026 | Bank of New York Mellon Corp | 567,973 | $10.41M | 0.0% | N/A | 0.183% |  |
| 8/6/2026 | State of Wyoming | 15,500 | $0.28M | 0.0% | N/A | 0.005% |  |
| 7/10/2026 | Tema ETFs LLC | 182,438 | $3.34M | 0.1% | -19.6% | 0.059% |  |
| 7/10/2026 | Handelsbanken Fonder AB | 81,900 | $1.50M | 0.0% | N/A | 0.026% |  |
| 7/10/2026 | Wealthcare Advisory Partners LLC | 15,924 | $0.29M | 0.0% | +5.0% | 0.005% |  |
| 7/8/2026 | Assenagon Asset Management S.A. | 812,876 | $14.89M | 0.0% | N/A | 0.261% |  |
| 6/4/2026 | Seven Fleet Capital Management LP | 222,468 | $3.60M | 1.1% | N/A | 0.072% |  |
| 5/20/2026 | Vivo Capital LLC | 12,151,480 | $196.61M | 16.3% | +31.0% | 3.907% |  |
| 5/19/2026 | Bank of America Corp DE | 3,055,897 | $49.44M | 0.0% | +89.6% | 0.983% |  |
| 5/19/2026 | Stempoint Capital LP | 239,861 | $3.88M | 0.7% | N/A | 0.077% |  |
| 5/19/2026 | Janus Henderson Group PLC | 3,710,966 | $59.99M | 0.0% | N/A | 1.193% |  |
| 5/18/2026 | ADAR1 Capital Management LLC | 10,000 | $0.16M | 0.0% | N/A | 0.003% |  |
| 5/18/2026 | EverSource Wealth Advisors LLC | 4,249 | $69K | 0.0% | +77.8% | 0.001% |  |
| 5/18/2026 | California State Teachers Retirement System | 204,449 | $3.31M | 0.0% | +1,812.7% | 0.066% |  |
| 5/18/2026 | Rock Springs Capital Management LP | 1,103,469 | $17.85M | 1.1% | +15.9% | 0.355% |  |
| 5/18/2026 | EcoR1 Capital LLC | 900,000 | $14.56M | 0.6% | N/A | 0.289% |  |
| 5/16/2026 | The Manufacturers Life Insurance Company | 216,614 | $3.51M | 0.0% | +295.5% | 0.070% |  |
| 5/15/2026 | Commodore Capital LP | 3,175,000 | $51.37M | 3.0% | N/A | 1.021% |  |
| 5/15/2026 | Affinity Asset Advisors LLC | 5,350,000 | $86.56M | 4.5% | +37.2% | 1.720% |  |
| 5/15/2026 | Spruce Street Capital LP | 422,543 | $6.84M | 1.6% | -89.1% | 0.136% |  |
| 5/14/2026 | Renaissance Technologies LLC | 1,398,869 | $22.63M | 0.0% | +64.6% | 0.450% |  |
| 5/14/2026 | Siren L.L.C. | 11,244,246 | $181.93M | 5.0% | +28.4% | 3.616% |  |
| 5/14/2026 | Sei Investments Co. | 31,760 | $0.51M | 0.0% | +90.4% | 0.010% |  |
| 5/14/2026 | State of Wyoming | 5,850 | $95K | 0.0% | N/A | 0.002% |  |
| 5/8/2026 | Baader Bank Aktiengesellschaft | 18,000 | $0.29M | 0.0% | N/A | 0.006% |  |
| 5/7/2026 | Dimensional Fund Advisors LP | 1,786,389 | $28.87M | 0.0% | +0.6% | 0.574% |  |
| 5/7/2026 | KBC Group NV | 4,996 | $81K | 0.0% | N/A | 0.002% |  |
| 5/7/2026 | Swiss National Bank | 336,800 | $5.45M | 0.0% | N/A | 0.108% |  |
| 5/5/2026 | Marks Group Wealth Management Inc | 29,879 | $0.48M | 0.0% | N/A | 0.010% |  |
| 5/5/2026 | Bank of New York Mellon Corp | 559,629 | $9.06M | 0.0% | +2.4% | 0.180% |  |
| 4/28/2026 | Abel Hall LLC | 16,947 | $0.27M | 0.1% | +8.1% | 0.005% |  |
| 4/25/2026 | Strs Ohio | 33,000 | $0.53M | 0.0% | N/A | 0.011% |  |
| 4/22/2026 | Pictet Asset Management Holding SA | 208,273 | $3.15M | 0.0% | N/A | 0.067% |  |
| 4/22/2026 | Sterling Capital Management LLC | 6,348 | $0.10M | 0.0% | -37.2% | 0.002% |  |
| 4/16/2026 | SG Americas Securities LLC | 44,697 | $0.72M | 0.0% | -8.2% | 0.014% |  |
| 2/19/2026 | T. Rowe Price Investment Management Inc. | 16,111,414 | $59.94M | 0.0% | -20.4% | 5.204% |  |
| 2/19/2026 | Invesco Ltd. | 329,795 | $1.23M | 0.0% | +16.9% | 0.107% |  |
| 2/18/2026 | EP Wealth Advisors LLC | 30,000 | $0.11M | 0.0% | N/A | 0.010% |  |
| 2/18/2026 | XTX Topco Ltd | 10,798 | $40K | 0.0% | N/A | 0.003% |  |
| 2/18/2026 | Ikarian Capital LLC | 735,396 | $2.74M | 0.2% | N/A | 0.238% |  |
| 2/18/2026 | Wellington Management Group LLP | 543,196 | $2.02M | 0.0% | -9.6% | 0.175% |  |
| 2/18/2026 | Susquehanna Portfolio Strategies LLC | 59,087 | $0.22M | 0.0% | +58.4% | 0.019% |  |
| 2/18/2026 | Tang Capital Management LLC | 900,000 | $3.35M | 0.2% | -40.1% | 0.291% |  |
| 2/18/2026 | Tudor Investment Corp ET AL | 53,436 | $0.20M | 0.0% | N/A | 0.017% |  |
| 2/18/2026 | Quadrature Capital Ltd | 13,162 | $49K | 0.0% | N/A | 0.004% |  |
| 2/18/2026 | RTW Investments LP | 146,651 | $0.55M | 0.0% | N/A | 0.047% |  |
| 2/18/2026 | Millennium Management LLC | 2,237,951 | $8.33M | 0.0% | -28.3% | 0.723% |  |
| 2/18/2026 | Balyasny Asset Management L.P. | 98,073 | $0.37M | 0.0% | -2.4% | 0.032% |  |
| 2/18/2026 | Boothbay Fund Management LLC | 188,467 | $0.70M | 0.0% | N/A | 0.061% |  |
| 2/17/2026 | Logos Global Management LP | 13,000,000 | $48.36M | 2.9% | -14.2% | 4.199% |  |
| 2/17/2026 | AQR Capital Management LLC | 669,876 | $2.49M | 0.0% | +0.8% | 0.216% |  |
| 2/17/2026 | Abel Hall LLC | 15,682 | $58K | 0.0% | N/A | 0.005% |  |
| 2/17/2026 | Jain Global LLC | 42,336 | $0.16M | 0.0% | N/A | 0.014% |  |
| 2/17/2026 | Paradigm Biocapital Advisors LP | 14,159,095 | $52.67M | 1.3% | +4.4% | 4.574% |  |
| 2/17/2026 | Price T Rowe Associates Inc. MD | 103,503 | $0.39M | 0.0% | +10.6% | 0.033% |  |
| 2/17/2026 | T. Rowe Price Investment Management Inc. | 4,786,825 | $17.81M | 0.0% | -76.3% | 1.546% |  |
| 2/17/2026 | Rock Springs Capital Management LP | 951,710 | $3.54M | 0.2% | N/A | 0.307% |  |
| 2/17/2026 | Captrust Financial Advisors | 17,606 | $65K | 0.0% | -23.1% | 0.006% |  |
| 2/17/2026 | ExodusPoint Capital Management LP | 1,490,967 | $5.55M | 0.0% | N/A | 0.482% |  |
| 2/16/2026 | Squarepoint Ops LLC | 258,275 | $0.96M | 0.0% | +204.9% | 0.083% |  |
| 2/16/2026 | Spruce Street Capital LP | 3,889,632 | $14.47M | 4.8% | N/A | 1.256% |  |
| 2/16/2026 | Panagora Asset Management Inc. | 118,218 | $0.44M | 0.0% | +15.5% | 0.038% |  |
| 2/16/2026 | Mariner LLC | 10,825 | $40K | 0.0% | N/A | 0.003% |  |
| 2/16/2026 | Barclays PLC | 402,796 | $1.50M | 0.0% | +50.2% | 0.130% |  |
| 2/13/2026 | Marshall Wace LLP | 61,960 | $0.23M | 0.0% | -88.2% | 0.020% |  |
| 2/13/2026 | The Manufacturers Life Insurance Company | 54,769 | $0.20M | 0.0% | -11.4% | 0.018% |  |
| 2/13/2026 | Affinity Asset Advisors LLC | 3,900,000 | $14.51M | 0.8% | -9.0% | 1.260% |  |
| 2/13/2026 | Stifel Financial Corp | 10,300 | $38K | 0.0% | N/A | 0.003% |  |
| 2/13/2026 | Hudson Bay Capital Management LP | 158,020 | $0.59M | 0.0% | N/A | 0.051% |  |