| 8/19/2026 | Wellington Management Group LLP | 1,647,852 | $16.69M | 0.0% | +5.5% | 1.229% |  |
| 7/10/2026 | Wasatch Advisors LP | 441,510 | $4.47M | 0.0% | -5.0% | 0.329% |  |
| 5/19/2026 | Bank of America Corp DE | 25,394 | $0.25M | 0.0% | +87.5% | 0.019% |  |
| 5/16/2026 | SummitTX Capital L.P. | 151,112 | $1.49M | 0.0% | +56.1% | 0.113% |  |
| 5/15/2026 | Troluce Capital Advisors LLC | 250,000 | $2.46M | 0.2% | N/A | 0.186% |  |
| 4/27/2026 | Y Intercept Hong Kong Ltd | 75,427 | $0.74M | 0.0% | N/A | 0.056% |  |
| 4/21/2026 | Wasatch Advisors LP | 464,823 | $4.57M | 0.0% | -9.8% | 0.347% |  |
| 4/16/2026 | SG Americas Securities LLC | 99,441 | $0.98M | 0.0% | -52.3% | 0.074% |  |
| 2/19/2026 | T. Rowe Price Investment Management Inc. | 21,459,156 | $225.32M | 0.1% | +10.7% | 17.655% |  |
| 2/18/2026 | Vestal Point Capital LP | 6,125,000 | $64.31M | 2.2% | -3.5% | 5.039% |  |
| 2/18/2026 | Virtus Investment Advisers LLC | 26,497 | $0.28M | 0.1% | +43.0% | 0.022% |  |
| 2/18/2026 | SummitTX Capital L.P. | 96,784 | $1.02M | 0.0% | +117.7% | 0.080% |  |
| 2/18/2026 | Tudor Investment Corp ET AL | 54,720 | $0.58M | 0.0% | N/A | 0.045% |  |
| 2/18/2026 | Sphera Funds Management LTD. | 861,105 | $9.04M | 1.7% | +47.7% | 0.708% |  |
| 2/18/2026 | Suvretta Capital Management LLC | 11,190,129 | $117.50M | 2.4% | -7.0% | 9.206% |  |
| 2/18/2026 | RTW Investments LP | 11,433,354 | $120.05M | 1.2% | +29.7% | 9.406% |  |
| 2/18/2026 | Perceptive Advisors LLC | 10,383,456 | $109.03M | 1.9% | +10.7% | 8.543% |  |
| 2/18/2026 | Millennium Management LLC | 83,122 | $0.87M | 0.0% | -88.5% | 0.068% |  |
| 2/18/2026 | Ishara Investments LP | 80,000 | $0.84M | 1.0% | N/A | 0.066% |  |
| 2/18/2026 | Balyasny Asset Management L.P. | 592,428 | $6.22M | 0.0% | N/A | 0.487% |  |
| 2/17/2026 | Burkehill Global Management LP | 150,000 | $1.58M | 0.1% | N/A | 0.123% |  |
| 2/17/2026 | Jump Financial LLC | 50,868 | $0.53M | 0.0% | N/A | 0.042% |  |
| 2/17/2026 | Price T Rowe Associates Inc. MD | 748,035 | $7.86M | 0.0% | +3.2% | 0.615% |  |
| 2/17/2026 | T. Rowe Price Investment Management Inc. | 4,789,996 | $50.30M | 0.1% | -75.3% | 3.941% |  |
| 2/17/2026 | Graham Capital Management L.P. | 19,630 | $0.21M | 0.0% | N/A | 0.016% |  |
| 2/16/2026 | Sofinnova Investments Inc. | 3,435,542 | $36.07M | 1.5% | +54.2% | 2.826% |  |
| 2/16/2026 | Vanguard Personalized Indexing Management LLC | 49,374 | $0.52M | 0.0% | +3.7% | 0.041% |  |
| 2/16/2026 | Verition Fund Management LLC | 206,568 | $2.17M | 0.0% | +357.0% | 0.170% |  |
| 2/16/2026 | Barclays PLC | 28,185 | $0.30M | 0.0% | +11.4% | 0.023% |  |
| 2/13/2026 | The Manufacturers Life Insurance Company | 55,300 | $0.56M | 0.0% | +18.2% | 0.045% |  |
| 2/13/2026 | Quarry LP | 8,001 | $84K | 0.0% | N/A | 0.007% |  |
| 2/13/2026 | Schroder Investment Management Group | 402,352 | $4.05M | 0.0% | -6.0% | 0.331% |  |
| 2/13/2026 | Alyeska Investment Group L.P. | 789,163 | $8.29M | 0.0% | +163.1% | 0.649% |  |
| 2/13/2026 | State Street Corp | 444,658 | $4.67M | 0.0% | +103.5% | 0.366% |  |
| 2/12/2026 | Wasatch Advisors LP | 515,128 | $5.41M | 0.0% | -28.3% | 0.424% |  |
| 2/12/2026 | Jane Street Group LLC | 104,929 | $1.10M | 0.0% | N/A | 0.086% |  |
| 2/12/2026 | Alps Advisors Inc. | 110,082 | $1.16M | 0.0% | N/A | 0.091% |  |
| 2/12/2026 | Monashee Investment Management LLC | 160,336 | $1.68M | 0.9% | N/A | 0.132% |  |
| 2/11/2026 | Fox Run Management L.L.C. | 12,307 | $0.13M | 0.0% | N/A | 0.010% |  |
| 2/10/2026 | TD Asset Management Inc | 500,724 | $5.26M | 0.0% | +30.5% | 0.412% |  |
| 2/10/2026 | Goldman Sachs Group Inc. | 323,023 | $3.39M | 0.0% | +69.3% | 0.266% |  |
| 2/9/2026 | Geode Capital Management LLC | 134,763 | $1.42M | 0.0% | +96.1% | 0.111% |  |
| 2/9/2026 | Sectoral Asset Management Inc. | 63,015 | $0.66M | 0.5% | -88.8% | 0.052% |  |
| 2/9/2026 | Jefferies Financial Group Inc. | 5,059,551 | $53.13M | 0.3% | +323.4% | 4.163% |  |
| 2/3/2026 | Mitsubishi UFJ Asset Management Co. Ltd. | 16,955 | $0.18M | 0.0% | -46.9% | 0.014% |  |
| 1/29/2026 | UBS Group AG | 563,463 | $5.92M | 0.0% | +61.3% | 0.464% |  |
| 1/16/2026 | Aberdeen Group plc | 714,569 | $7.50M | 0.0% | -9.5% | 0.588% |  |
| 1/9/2026 | SG Americas Securities LLC | 208,456 | $2.19M | 0.0% | N/A | 0.171% |  |
| 1/1/2026 | JPMorgan Chase & Co. | 135,957 | $1.16M | 0.0% | -31.6% | 0.112% |  |
| 11/17/2025 | Woodline Partners LP | 1,841,602 | $15.69M | 0.1% | -52.5% | 1.515% |  |
| 11/17/2025 | Alyeska Investment Group L.P. | 300,000 | $2.56M | 0.0% | N/A | 0.247% |  |
| 11/17/2025 | Wasatch Advisors LP | 718,897 | $6.13M | 0.0% | -8.4% | 0.591% |  |
| 11/17/2025 | Verition Fund Management LLC | 45,202 | $0.39M | 0.0% | N/A | 0.037% |  |
| 11/17/2025 | Vestal Point Capital LP | 6,350,000 | $54.10M | 2.4% | +1.6% | 5.224% |  |
| 11/17/2025 | Qube Research & Technologies Ltd | 154,753 | $1.32M | 0.0% | -45.3% | 0.127% |  |
| 11/17/2025 | Millennium Management LLC | 721,866 | $6.15M | 0.0% | +4,991.1% | 0.594% |  |
| 11/17/2025 | Baker BROS. Advisors LP | 12,094,094 | $103.04M | 0.7% | +18.9% | 9.950% |  |
| 11/14/2025 | Orbimed Advisors LLC | 466,601 | $3.98M | 0.1% | -35.2% | 0.384% |  |
| 11/14/2025 | Wellington Management Group LLP | 1,512,241 | $12.88M | 0.0% | -71.6% | 1.244% |  |
| 11/13/2025 | UBS Group AG | 349,379 | $2.98M | 0.0% | -13.6% | 0.287% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 122,510 | $1.04M | 0.0% | +56.8% | 0.101% |  |
| 11/13/2025 | Jefferies Financial Group Inc. | 1,194,915 | $10.18M | 0.0% | N/A | 0.983% |  |
| 11/12/2025 | Insigneo Advisory Services LLC | 12,062 | $0.10M | 0.0% | N/A | 0.010% |  |
| 11/10/2025 | TD Asset Management Inc | 383,804 | $3.27M | 0.0% | +33.1% | 0.316% |  |
| 11/7/2025 | Readystate Asset Management LP | 49,947 | $0.43M | 0.0% | N/A | 0.041% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 135,957 | $1.16M | 0.0% | -31.6% | 0.112% |  |
| 11/7/2025 | Aberdeen Group plc | 789,446 | $6.73M | 0.0% | +9.7% | 0.649% |  |
| 10/31/2025 | Vanguard Personalized Indexing Management LLC | 47,635 | $0.41M | 0.0% | +8.3% | 0.039% |  |
| 10/15/2025 | Vontobel Holding Ltd. | 10,000 | $85K | 0.0% | -9.1% | 0.008% |  |
| 8/15/2025 | Vestal Point Capital LP | 6,250,000 | $33.63M | 1.8% | -13.1% | 5.142% |  |
| 8/15/2025 | Wasatch Advisors LP | 785,154 | $4.22M | 0.0% | +35.9% | 0.646% |  |
| 8/15/2025 | Sofinnova Investments Inc. | 2,240,528 | $12.05M | 0.7% | +44.1% | 1.843% |  |
| 8/15/2025 | Engineers Gate Manager LP | 23,133 | $0.12M | 0.0% | N/A | 0.019% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 78,123 | $0.42M | 0.0% | +105.2% | 0.064% |  |
| 8/15/2025 | 683 Capital Management LLC | 540,000 | $2.91M | 0.2% | -12.2% | 0.444% |  |
| 8/14/2025 | Orbimed Advisors LLC | 719,901 | $3.87M | 0.1% | -76.7% | 0.592% |  |
| 8/14/2025 | Qube Research & Technologies Ltd | 282,678 | $1.52M | 0.0% | -41.0% | 0.233% |  |
| 8/13/2025 | Virtus Investment Advisers LLC | 15,315 | $82K | 0.0% | -30.9% | 0.013% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 198,769 | $1.07M | 0.0% | +31.5% | 0.164% |  |
| 8/7/2025 | Mitsubishi UFJ Asset Management Co. Ltd. | 31,894 | $0.17M | 0.0% | +28.7% | 0.026% |  |
| 8/6/2025 | Fox Run Management L.L.C. | 25,233 | $0.14M | 0.0% | N/A | 0.021% |  |
| 7/28/2025 | TD Asset Management Inc | 288,256 | $1.55M | 0.0% | +19.5% | 0.237% |  |
| 7/25/2025 | Vanguard Personalized Indexing Management LLC | 43,969 | $0.24M | 0.0% | N/A | 0.036% |  |
| 7/23/2025 | Vontobel Holding Ltd. | 11,000 | $59K | 0.0% | N/A | 0.009% |  |
| 5/16/2025 | Woodline Partners LP | 1,684,285 | $7.60M | 0.0% | -17.2% | 1.386% |  |
| 5/16/2025 | Zimmer Partners LP | 145,990 | $0.66M | 0.0% | -64.0% | 0.120% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 1,987,292 | $8.96M | 0.0% | -16.5% | 1.635% |  |
| 5/16/2025 | 683 Capital Management LLC | 615,000 | $2.77M | 0.2% | -5.4% | 0.506% |  |
| 5/15/2025 | Vestal Point Capital LP | 7,192,700 | $32.44M | 2.3% | +14.6% | 5.917% |  |
| 5/15/2025 | Frazier Life Sciences Management L.P. | 1,247,911 | $5.63M | 0.3% | -41.9% | 1.027% |  |
| 5/15/2025 | Paradigm Biocapital Advisors LP | 1,907,108 | $8.60M | 0.4% | -64.8% | 1.569% |  |
| 5/15/2025 | Trexquant Investment LP | 173,518 | $0.78M | 0.0% | N/A | 0.143% |  |
| 5/14/2025 | Pale Fire Capital SE | 34,270 | $0.16M | 0.0% | +8.9% | 0.028% |  |
| 5/14/2025 | T. Rowe Price Investment Management Inc. | 14,677,003 | $66.19M | 0.0% | +38.4% | 12.075% |  |
| 5/14/2025 | Wellington Management Group LLP | 8,583,568 | $38.71M | 0.0% | -17.6% | 7.062% |  |
| 5/13/2025 | Algert Global LLC | 70,668 | $0.32M | 0.0% | +20.6% | 0.058% |  |
| 5/13/2025 | Aberdeen Group plc | 719,586 | $3.25M | 0.0% | +107.1% | 0.592% |  |
| 5/13/2025 | Russell Investments Group Ltd. | 95,383 | $0.43M | 0.0% | N/A | 0.078% |  |
| 5/8/2025 | XTX Topco Ltd | 126,957 | $0.57M | 0.0% | N/A | 0.104% |  |
| 5/7/2025 | TD Asset Management Inc | 241,246 | $1.09M | 0.0% | -5.1% | 0.198% |  |