IONS Insider Trading

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Insider Trading History
Frequently Asked Questions
About

Insider Ownership Percentage: 2.60%

Insider Buying (Last 12 Months): $659,000.00

Insider Selling (Last 12 Months): $4,708,098.31

Ionis Pharmaceuticals Insider Trading History Chart

Ionis Pharmaceuticals Share Price & Price History

^$42.77

▲ +0.77 (1.83%)

As of 07/16/2025 05:00 PM ET

Days: 30 | 90 | 365

Ionis Pharmaceuticals Insider Trading History

Transaction Date	Insider Name	Title	Buy/Sell	Number of Shares	Average Share Price	Total Transaction	Shares Held After Transaction
7/11/2025	Brett P. Monia	CEO	Sell	1,160	$41.74	$48,418.40	179,820
5/1/2025	Michael R. Hayden	Director	Buy	15,000	$31.86	$477,900.00	50,219
4/16/2025	Brian Birchler	EVP	Sell	680	$28.37	$19,291.60	56,660
3/11/2025	Brett P. Monia	CEO	Sell	140	$32.32	$4,524.80	180,980
2/20/2025	Patrick R. O'Neil	EVP	Sell	1,207	$32.35	$39,046.45	56,245
2/4/2025	Brett P. Monia	CEO	Sell	38,843	$31.65	$1,229,380.95	180,683
2/4/2025	Patrick R. O'Neil	EVP	Sell	6,165	$31.62	$194,937.30	57,452
1/31/2025	Brett P. Monia	CEO	Sell	13,242	$32.45	$429,702.90	219,526
1/31/2025	Elizabeth L. Hougen	CFO	Sell	1,523	$32.44	$49,406.12	110,500
1/31/2025	Eric Swayze	EVP	Sell	1,367	$32.31	$44,167.77	48,017
1/16/2025	Brett P. Monia	CEO	Sell	33,445	$32.63	$1,091,310.35	207,396
1/16/2025	Elizabeth L. Hougen	CFO	Sell	8,870	$32.81	$291,024.70	107,885
1/16/2025	Eric Swayze	EVP	Sell	7,154	$32.84	$234,937.36	45,670
12/23/2024	Michael R. Hayden	Director	Buy	5,000	$36.22	$181,100.00	35,219
11/12/2024	Brett P. Monia	CEO	Sell	6,630	$38.05	$252,271.50	167,393
11/12/2024	Eric Swayze	EVP	Sell	1,194	$37.92	$45,276.48	33,713
10/16/2024	Eric Swayze	EVP	Sell	53	$38.31	$2,030.43	157
8/28/2024	Richard S. Geary	EVP	Sell	320	$49.16	$15,731.20	85,154
8/5/2024	Richard S. Geary	EVP	Sell	2,430	$48.00	$116,640.00	85,508
7/16/2024	Joseph Klein, III	Director	Sell	12,000	$50.00	$600,000.00	16,346
5/3/2024	Joseph Klein, III	Director	Sell	6,000	$42.71	$256,260.00	16,346
4/16/2024	Joseph Baroldi	EVP	Sell	4,006	$41.60	$166,649.60	19,631
2/16/2024	Brett P. Monia	CEO	Sell	387	$44.49	$17,217.63	173,751
2/2/2024	Brett P. Monia	CEO	Sell	23,501	$49.37	$1,160,244.37	174,138
2/2/2024	Elizabeth L. Hougen	CFO	Sell	2,125	$49.54	$105,272.50	92,905
2/2/2024	Eric Swayze	EVP	Sell	1,907	$49.56	$94,510.92	34,324
1/31/2024	Eric Swayze	EVP	Sell	10,773	$52.00	$560,196.00	32,516
1/25/2024	Brett P. Monia	CEO	Sell	2,285	$51.75	$118,248.75	151,851
1/25/2024	Patrick R. O'Neil	EVP	Sell	6,450	$51.75	$333,787.50	46,802
1/17/2024	Brett P. Monia	CEO	Sell	32,059	$50.42	$1,616,414.78	154,136
1/17/2024	Elizabeth L. Hougen	CFO	Sell	8,683	$50.42	$437,796.86	90,890
1/17/2024	Onaiza J. Cadoret-Manier	EVP	Sell	5,564	$50.42	$280,536.88	33,810
1/12/2024	Eugene Schneider	EVP	Sell	8,000	$53.50	$428,000.00	38,170
12/28/2023	B. Lynne Parshall, Esq.	Director	Sell	42,525	$50.19	$2,134,329.75	82,588
12/26/2023	B. Lynne Parshall, Esq.	Director	Sell	25,113	$51.46	$1,292,314.98	82,588
12/26/2023	Patrick R. O'Neil	EVP	Sell	20,825	$51.46	$1,071,654.50	40,355
12/21/2023	Brett P. Monia	CEO	Sell	17,500	$49.29	$862,575.00	118,111
12/20/2023	C. Frank Bennett	EVP	Sell	6,500	$49.64	$322,660.00	65,754
12/14/2023	Brett P. Monia	CEO	Sell	24,000	$49.58	$1,189,920.00	118,111
11/15/2023	Joseph Klein, III	Director	Sell	2,000	$50.00	$100,000.00	16,346
10/17/2023	Eric Swayze	EVP	Sell	52	$47.95	$2,493.40	73
10/12/2023	Brett P. Monia	CEO	Sell	3,770	$46.00	$173,420.00	118,111
9/28/2023	C. Frank Bennett	EVP	Sell	4,460	$46.50	$207,390.00	65,754
9/26/2023	B. Lynne Parshall, Esq.	Director	Sell	10,000	$45.13	$451,300.00	82,588
8/1/2023	Allene M. Diaz	Director	Sell	657	$41.05	$26,969.85	12,676
7/18/2023	Joseph Klein, III	Director	Sell	3,555	$42.00	$149,310.00	20,346
7/7/2023	Brett P. Monia	CEO	Sell	18,650	$42.25	$787,962.50	121,724
5/24/2023	Patrick R. O'Neil	EVP	Sell	1,527	$41.70	$63,675.90	40,355
5/22/2023	Brett P. Monia	CEO	Sell	4,931	$40.14	$197,930.34	140,374
4/18/2023	Brian Birchler	EVP	Sell	672	$36.50	$24,528.00	36,528
2/6/2023	Brett P. Monia	CEO	Sell	24,651	$40.69	$1,003,049.19	145,305
2/6/2023	Elizabeth L. Hougen	CFO	Sell	2,079	$40.59	$84,386.61	75,496
2/6/2023	Eric Swayze	EVP	Sell	1,815	$40.79	$74,033.85	31,941
1/30/2023	Patrick R. O'Neil	EVP	Sell	4,500	$39.42	$177,390.00	44,179
1/18/2023	Brett P. Monia	CEO	Sell	25,066	$39.49	$989,856.34	120,863
1/18/2023	Elizabeth L. Hougen	CFO	Sell	8,280	$39.70	$328,716.00	73,435
1/18/2023	Eric Swayze	EVP	Sell	5,631	$39.74	$223,775.94	30,041
1/17/2023	Joseph Klein, III	Director	Sell	2,000	$40.00	$80,000.00	16,791
9/8/2022	Eric Swayze	EVP	Sell	460	$44.55	$20,493.00	19,892
7/15/2022	Joseph Klein, III	Director	Sell	1,333	$38.24	$50,973.92	18,791

SEC Filings (Institutional Ownership Changes) for Ionis Pharmaceuticals (NASDAQ:IONS)

93.86% of Ionis Pharmaceuticals stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

Ionis Pharmaceuticals Institutional Trading History

Reporting Date	Hedge Fund	Shares Held	Market Value	% of Portfolio	Quarterly Change in Shares	Ownership in Company
7/16/2025	Signaturefd LLC	2,030	$80K	0.0%	+46.9%	0.001%
7/15/2025	Significant Wealth Partners LLC	15,504	$0.61M	0.3%	+14.0%	0.010%
7/15/2025	Fifth Third Bancorp	7,598	$0.30M	0.0%	-23.9%	0.005%
7/11/2025	Assenagon Asset Management S.A.	17,654	$0.70M	0.0%	N/A	0.011%
7/10/2025	Wedmont Private Capital	5,282	$0.23M	0.0%	N/A	0.003%
7/10/2025	Sovran Advisors LLC	321,913	$13.31M	1.4%	-2.1%	0.202%
7/8/2025	Parallel Advisors LLC	1,872	$74K	0.0%	+151.3%	0.001%
5/29/2025	Rhumbline Advisers	188,216	$5.68M	0.0%	-1.9%	0.118%
5/20/2025	Focus Partners Wealth	9,832	$0.30M	0.0%	+30.1%	0.006%
5/19/2025	UBS AM A Distinct Business Unit of UBS Asset Management Americas LLC	659,435	$19.90M	0.0%	+6.4%	0.414%
5/16/2025	Exome Asset Management LLC	135,616	$4.09M	3.5%	+121.0%	0.085%
5/16/2025	Goldman Sachs Group Inc.	652,518	$19.69M	0.0%	+72.5%	0.410%
5/16/2025	Teza Capital Management LLC	10,244	$0.31M	0.1%	+20.2%	0.006%
5/16/2025	Millennium Management LLC	635,370	$19.17M	0.0%	-17.9%	0.399%
5/16/2025	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	8,206	$0.26M	0.0%	-13.2%	0.005%
5/16/2025	Edmond DE Rothschild Holding S.A.	124,200	$3.75M	0.1%	N/A	0.078%
5/16/2025	BVF Inc. IL	1,913,385	$57.73M	2.4%	N/A	1.202%
5/16/2025	Allostery Investments LP	35,000	$1.06M	1.5%	-46.2%	0.022%
5/16/2025	Ancora Advisors LLC	2,000	$60K	0.0%	N/A	0.001%
5/16/2025	Adage Capital Partners GP L.L.C.	1,075,600	$32.45M	0.1%	+291.1%	0.676%
5/15/2025	Baker BROS. Advisors LP	357,915	$10.80M	0.1%	-98.8%	0.225%
5/15/2025	PDT Partners LLC	96,056	$2.90M	0.2%	+231.3%	0.060%
5/15/2025	Alpine Global Management LLC	28,097	$0.85M	0.2%	N/A	0.018%
5/15/2025	Quarry LP	3,000	$91K	0.0%	-50.0%	0.002%
5/15/2025	Tema Etfs LLC	25,141	$0.76M	0.2%	-55.8%	0.016%
5/15/2025	Orion Investment Co	215,290	$6.50M	2.7%	-0.3%	0.135%
5/14/2025	Rafferty Asset Management LLC	176,248	$5.32M	0.0%	-25.7%	0.111%
5/14/2025	FORA Capital LLC	11,570	$0.35M	0.0%	N/A	0.007%
5/14/2025	Comerica Bank	1,320	$40K	0.0%	-82.1%	0.001%
5/14/2025	Jump Financial LLC	81,321	$2.45M	0.0%	+104.6%	0.051%
5/14/2025	Northwestern Mutual Wealth Management Co.	12,358	$0.37M	0.0%	+9.1%	0.008%
5/14/2025	Price T Rowe Associates Inc. MD	3,265,034	$98.51M	0.0%	-14.7%	2.051%
5/14/2025	Candriam S.C.A.	993,704	$29.98M	0.2%	+16.9%	0.624%
5/14/2025	T. Rowe Price Investment Management Inc.	16,175,533	$488.02M	0.3%	+14.2%	10.163%
5/14/2025	Capital Fund Management S.A.	58,014	$1.75M	0.0%	N/A	0.036%
5/14/2025	Groupama Asset Managment	1,069,211	$32.26M	0.3%	+5.1%	0.672%
5/14/2025	Hsbc Holdings PLC	74,833	$2.22M	0.0%	-9.9%	0.047%
5/13/2025	Northern Trust Corp	834,847	$25.19M	0.0%	-0.6%	0.525%
5/13/2025	Raymond James Financial Inc.	148,690	$4.49M	0.0%	+40.8%	0.093%
5/13/2025	Tocqueville Asset Management L.P.	187,395	$5.65M	0.1%	-46.8%	0.118%
5/13/2025	American Century Companies Inc.	116,768	$3.52M	0.0%	N/A	0.073%
5/13/2025	Sector Gamma AS	285,842	$8.62M	2.8%	+21.2%	0.180%
5/13/2025	Aberdeen Group plc	446,197	$13.50M	0.0%	+11.1%	0.280%
5/13/2025	Liontrust Investment Partners LLP	30,390	$0.92M	0.0%	-27.0%	0.019%
5/13/2025	E Fund Management Co. Ltd.	16,471	$0.50M	0.0%	-2.4%	0.010%
5/12/2025	Connor Clark & Lunn Investment Management Ltd.	129,273	$3.90M	0.0%	+3.1%	0.081%
5/12/2025	Swiss National Bank	275,300	$8.31M	0.0%	-1.4%	0.173%
5/12/2025	Mitsubishi UFJ Asset Management Co. Ltd.	6,135	$0.19M	0.0%	+8.5%	0.004%
5/9/2025	Charles Schwab Investment Management Inc.	1,443,629	$43.55M	0.0%	-2.6%	0.907%
5/9/2025	Vanguard Group Inc.	16,383,934	$494.30M	0.0%	-0.5%	10.294%
5/9/2025	IQ EQ FUND MANAGEMENT IRELAND Ltd	8,059	$0.24M	0.0%	N/A	0.005%
5/9/2025	Raiffeisen Bank International AG	41,754	$1.30M	0.0%	+2,280.5%	0.026%
5/9/2025	Blair William & Co. IL	38,381	$1.16M	0.0%	-3.8%	0.024%
5/9/2025	Privium Fund Management B.V.	267,594	$8.07M	2.1%	+0.3%	0.168%
5/8/2025	Commerce Bank	7,275	$0.22M	0.0%	-46.4%	0.005%
5/8/2025	Jefferies Financial Group Inc.	22,841	$0.69M	0.0%	-99.2%	0.014%
5/8/2025	XTX Topco Ltd	12,404	$0.37M	0.0%	-51.1%	0.008%
5/7/2025	ARK Investment Management LLC	1,000,527	$30.19M	0.3%	-2.4%	0.629%
5/7/2025	TD Asset Management Inc	1,100,466	$33.20M	0.0%	+4.8%	0.691%
5/7/2025	Nikko Asset Management Americas Inc.	142,433	$4.30M	0.1%	-9.1%	0.089%
5/6/2025	Pinnacle Associates Ltd.	608,517	$18.36M	0.3%	+11.1%	0.383%
5/6/2025	Readystate Asset Management LP	46,394	$1.40M	0.0%	-99.6%	0.029%
5/6/2025	KLP Kapitalforvaltning AS	27,400	$0.83M	0.0%	-6.2%	0.017%
5/5/2025	GW&K Investment Management LLC	182,309	$5.50M	0.1%	-2.6%	0.115%
5/5/2025	Private Advisor Group LLC	34,531	$1.04M	0.0%	-15.1%	0.022%
5/2/2025	Grandfield & Dodd LLC	37,761	$1.14M	0.1%	+5.2%	0.024%
5/2/2025	Victory Capital Management Inc.	18,641	$0.56M	0.0%	+3.5%	0.012%
5/2/2025	Signaturefd LLC	1,382	$42K	0.0%	+45.6%	0.001%
5/1/2025	Bleakley Financial Group LLC	22,284	$0.67M	0.0%	+31.5%	0.014%
5/1/2025	CWM LLC	2,435	$73K	0.0%	+18.7%	0.002%
5/1/2025	Westmount Partners LLC	12,961	$0.39M	0.1%	-3.7%	0.008%
5/1/2025	Arizona State Retirement System	40,687	$1.23M	0.0%	-1.1%	0.026%
5/1/2025	Xponance Inc.	20,319	$0.61M	0.0%	+5.1%	0.013%
4/30/2025	Significant Wealth Partners LLC	13,605	$0.41M	0.2%	+24.8%	0.009%
4/30/2025	Brown Advisory Inc.	12,026	$0.36M	0.0%	-5.5%	0.008%
4/30/2025	China Universal Asset Management Co. Ltd.	31,886	$0.96M	0.1%	-4.8%	0.020%
4/29/2025	Envestnet Asset Management Inc.	15,039	$0.45M	0.0%	-71.5%	0.009%
4/29/2025	GF Fund Management CO. LTD.	4,042	$0.12M	0.0%	+21.9%	0.003%
4/28/2025	Principal Financial Group Inc.	10,447	$0.32M	0.0%	-23.3%	0.007%
4/28/2025	Teacher Retirement System of Texas	500,451	$15.10M	0.1%	+660.7%	0.315%
4/28/2025	DAVENPORT & Co LLC	56,393	$1.70M	0.0%	-10.1%	0.035%
4/25/2025	Sovran Advisors LLC	328,904	$9.34M	1.2%	+91.4%	0.207%
4/25/2025	Sumitomo Mitsui Trust Group Inc.	142,433	$4.30M	0.0%	-9.1%	0.090%
4/22/2025	Moisand Fitzgerald Tamayo LLC	5,000	$0.15M	0.0%	N/A	0.003%
4/17/2025	Exchange Traded Concepts LLC	3,244	$98K	0.0%	+1,722.5%	0.002%
4/15/2025	Fifth Third Bancorp	9,989	$0.30M	0.0%	+4.8%	0.006%
4/15/2025	Handelsbanken Fonder AB	43,211	$1.30M	0.0%	-1.4%	0.027%
4/15/2025	SG Americas Securities LLC	20,050	$0.61M	0.0%	-16.2%	0.013%
4/8/2025	Rhumbline Advisers	188,216	$5.68M	0.0%	-1.9%	0.118%
4/7/2025	GAMMA Investing LLC	28,993	$0.96M	0.0%	+3,786.5%	0.018%
3/18/2025	California State Teachers Retirement System	133,902	$4.68M	0.0%	+6.1%	0.084%
2/19/2025	GF Fund Management CO. LTD.	3,315	$0.12M	0.0%	N/A	0.002%
2/19/2025	Public Employees Retirement System of Ohio	53,748	$1.88M	0.0%	-5.4%	0.034%
2/17/2025	UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	619,641	$21.66M	0.0%	-40.8%	0.392%
2/17/2025	Voloridge Investment Management LLC	316,943	$11.08M	0.0%	-16.7%	0.201%
2/17/2025	Woodline Partners LP	107,610	$3.76M	0.0%	N/A	0.068%
2/17/2025	Vestal Point Capital LP	595,000	$20.80M	1.2%	N/A	0.377%
2/17/2025	Two Sigma Advisers LP	1,349,211	$47.17M	0.1%	+1.3%	0.854%
2/17/2025	Two Sigma Investments LP	921,439	$32.21M	0.1%	+0.3%	0.584%
2/17/2025	Tidal Investments LLC	17,407	$0.61M	0.0%	-7.9%	0.011%

Data available starting January 2016

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an antisense injection for the treatment of polyneuropathy caused by hereditary transthyretin amyloidosis in adults; and WAYLIVRA, an antisense medicine for treatment for familial chylomicronemia syndrome (FCS) and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of ATTR; Olezarsen for patients with FCS and severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Tofersen to inhibit the production of superoxide dismutase 1; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus. In addition, the company develops IONIS-FB-LRx to inhibit the production of complement factor B and the alternative complement pathway; and ION224 to reduce the production of diacylglycerol acyltransferase 2. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with Metagenomi, Inc, AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis, Roche, Swedish Orphan Biovitrum AB, and PTC Therapeutics. The company was incorporated in 1989 and is based in Carlsbad, California.

Today's Range

Now: $42.77

$41.79

$42.91

50 Day Range

MA: $36.92

$32.26

$43.59

52 Week Range

Now: $42.77

$23.95

$52.34

Volume

1,384,412 shs

Average Volume

1,620,657 shs

Market Capitalization

$6.81 billion

P/E Ratio

N/A

Dividend Yield

N/A

Beta

0.23

Who are the company insiders with the largest holdings of Ionis Pharmaceuticals?: Ionis Pharmaceuticals' top insider investors include:
Brett P Monia (CEO)
Elizabeth L Hougen (CFO)
Richard S Geary (EVP)
B Lynne Parshall (Director)
C Frank Bennett (EVP)
Patrick R O'neil (EVP)
Brian Birchler (EVP)
Michael R Hayden (Director)
Eric Swayze (EVP)
Eugene Schneider (EVP)
Onaiza Cadoret-Manier (EVP)
Joseph Klein III (Director)
Joseph Baroldi (EVP)
Allene M Diaz (Director)
Learn More about top insider investors at Ionis Pharmaceuticals.
Who are the major institutional investors of Ionis Pharmaceuticals?: Ionis Pharmaceuticals' top institutional shareholders include:
Sovran Advisors LLC — 0.20%
Assenagon Asset Management S.A. — 0.01%
Significant Wealth Partners LLC — 0.01%
Fifth Third Bancorp — 0.00%
Wedmont Private Capital — 0.00%
Parallel Advisors LLC — 0.00%
Learn More about top institutional investors of Ionis Pharmaceuticals stock.
Which institutional investors are selling Ionis Pharmaceuticals stock?: In the last quarter, IONS stock was sold by these institutional investors:
Sovran Advisors LLC
Fifth Third Bancorp
In the previous year, company insiders that have sold Ionis Pharmaceuticals company stock include:
Brett P Monia (CEO)
Elizabeth L Hougen (CFO)
Richard S Geary (EVP)
B Lynne Parshall (Director)
C Frank Bennett (EVP)
Patrick R O'neil (EVP)
Brian Birchler (EVP)
Learn More investors selling Ionis Pharmaceuticals stock.
Which institutional investors are buying Ionis Pharmaceuticals stock?: During the last quarter, IONS stock was purchased by institutional investors including:
Assenagon Asset Management S.A.
Wedmont Private Capital
Significant Wealth Partners LLC
Parallel Advisors LLC