IONS Insider Trading

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Insider Trading History
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About

Insider Ownership Percentage: 1.81%

Insider Buying (Last 12 Months): $1,058,700.00

Insider Selling (Last 12 Months): $135,835,002.94

Ionis Pharmaceuticals Insider Trading History Chart

Ionis Pharmaceuticals Share Price & Price History

^$44.44

▼ -2.31 (-4.94%)

As of 09/18/2026 04:00 PM ET

Days: 30 | 90 | 365

Ionis Pharmaceuticals Insider Trading History

Transaction Date	Insider Name	Title	Buy/Sell	Number of Shares	Average Share Price	Total Transaction	Shares Held After Transaction
7/31/2026	Michael R. Hayden	Director	Buy	5,000	$51.60	$258,000.00	24,000
7/30/2026	Michael R. Hayden	Director	Buy	15,000	$53.38	$800,700.00	19,000
7/7/2026	Allene M. Diaz	Director	Sell	10,111	$85.42	$863,681.62	3,811
7/7/2026	C. Frank Bennett	EVP	Sell	5,536	$83.58	$462,698.88	75,018
7/7/2026	C. Frank Bennett	EVP	Sell	15,000	$85.46	$1,281,900.00	75,018
7/7/2026	Holly B. Kordasiewicz	EVP	Sell	362	$84.30	$30,516.60	22,096
6/26/2026	Brett P. Monia	CEO	Sell	50,000	$80.59	$4,029,500.00	245,571
6/26/2026	Eugene Schneider	EVP	Sell	26,000	$81.05	$2,107,300.00	77,114
6/26/2026	Patrick R. O'Neil	EVP	Sell	3,069	$80.00	$245,520.00	61,470
6/25/2026	Brett P. Monia	CEO	Sell	21,072	$78.49	$1,653,941.28	245,571
6/25/2026	Eric Swayze	EVP	Sell	10,602	$79.18	$839,466.36	21,759
6/24/2026	Brett P. Monia	CEO	Sell	14,565	$78.41	$1,142,041.65	245,571
6/15/2026	Spencer R. Berthelsen	Director	Sell	8,000	$73.49	$587,920.00	156,013
6/12/2026	Holly B. Kordasiewicz	EVP	Sell	60,846	$73.41	$4,466,704.86	22,458
6/1/2026	Spencer R. Berthelsen	Director	Sell	8,000	$75.67	$605,360.00	156,013
4/16/2026	Brian Birchler	EVP	Sell	973	$75.04	$73,013.92	67,500
4/16/2026	Kyle Jenne	EVP	Sell	4,902	$75.17	$368,483.34	23,713
4/15/2026	B. Lynne Parshall, Esq.	Director	Sell	5,000	$76.27	$381,350.00	51,344
4/2/2026	Shannon L. Devers	EVP	Sell	6,193	$74.05	$458,591.65	16,348
3/19/2026	Eugene Schneider	EVP	Sell	5,812	$70.97	$412,477.64	63,890
3/17/2026	Elizabeth L. Hougen	EVP	Sell	10,172	$73.21	$744,692.12	82,660
3/16/2026	Elizabeth L. Hougen	EVP	Sell	215,048	$72.40	$15,569,475.20	92,832
3/10/2026	Brett P. Monia	CEO	Sell	34,103	$75.92	$2,589,099.76	242,662
3/10/2026	Kyle Jenne	EVP	Sell	37,277	$75.85	$2,827,460.45	11,714
3/9/2026	Brett P. Monia	CEO	Sell	126,670	$75.20	$9,525,584.00	242,662
3/9/2026	Patrick R. O'Neil	EVP	Sell	10,148	$75.25	$763,637.00	62,211
3/3/2026	Allene M. Diaz	Director	Sell	54,878	$79.35	$4,354,569.30	3,811
3/3/2026	C. Frank Bennett	EVP	Sell	85,089	$79.23	$6,741,601.47	80,554
3/3/2026	Shannon L. Devers	EVP	Sell	20,106	$79.40	$1,596,416.40	22,541
2/13/2026	Eric Swayze	EVP	Sell	15,642	$81.76	$1,278,889.92	32,105
2/11/2026	B. Lynne Parshall, Esq.	Director	Sell	5,000	$82.72	$413,600.00	56,344
2/6/2026	Brett P. Monia	CEO	Sell	29,430	$85.79	$2,524,799.70	254,497
2/2/2026	C. Frank Bennett	EVP	Sell	85,089	$82.93	$7,056,430.77	80,293
1/30/2026	Brett P. Monia	CEO	Sell	62,970	$82.72	$5,208,878.40	283,927
1/30/2026	Brian Birchler	EVP	Sell	6,179	$83.03	$513,042.37	66,247
1/30/2026	C. Frank Bennett	EVP	Sell	5,885	$82.95	$488,160.75	100,293
1/30/2026	C. Frank Bennett	EVP	Sell	5,885	$82.95	$488,160.75	100,293
1/30/2026	Elizabeth L. Hougen	EVP	Sell	6,988	$83.24	$581,681.12	132,881
1/30/2026	Eric Swayze	EVP	Sell	6,179	$82.93	$512,424.47	47,747
1/30/2026	Eugene Schneider	EVP	Sell	6,179	$83.45	$515,637.55	69,702
1/30/2026	Patrick R. O'Neil	EVP	Sell	6,179	$83.53	$516,131.87	71,983
1/30/2026	Patrick R. O'Neil	EVP	Sell	6,179	$83.53	$516,131.87	71,983
1/22/2026	Shannon L. Devers	EVP	Sell	3,977	$81.34	$323,489.18	22,541
1/16/2026	Brett P. Monia	CEO	Sell	44,034	$74.82	$3,294,623.88	224,683
1/16/2026	Brian Birchler	EVP	Sell	8,480	$75.11	$636,932.80	60,435
1/16/2026	C. Frank Bennett	EVP	Sell	8,977	$75.15	$674,621.55	94,757
1/16/2026	Elizabeth L. Hougen	EVP	Sell	12,922	$75.22	$971,992.84	126,307
1/16/2026	Eric Swayze	EVP	Sell	9,884	$75.34	$744,660.56	41,935
1/16/2026	Eric Swayze	EVP	Sell	49	$75.97	$3,722.53	318
1/16/2026	Eugene Schneider	EVP	Sell	9,302	$75.59	$703,138.18	63,890
1/16/2026	Holly B. Kordasiewicz	EVP	Sell	4,141	$75.66	$313,308.06	14,718
1/16/2026	Kyle Jenne	EVP	Sell	1,823	$75.96	$138,475.08	16,389
1/16/2026	Patrick R. O'Neil	EVP	Sell	9,191	$75.84	$697,045.44	66,171
1/16/2026	Shannon L. Devers	EVP	Sell	8,353	$75.95	$634,410.35	26,518
1/7/2026	Shannon L. Devers	EVP	Sell	44,199	$85.08	$3,760,450.92	17,494
1/2/2026	Eric Swayze	EVP	Sell	23,463	$79.12	$1,856,392.56	30,453
12/1/2025	Joseph H. Wender	Director	Sell	28,000	$80.82	$2,262,960.00	36,035
11/25/2025	Shannon L. Devers	EVP	Sell	16,777	$80.91	$1,357,427.07	17,494
11/6/2025	Brian Birchler	EVP	Sell	8,000	$76.17	$609,360.00	48,826
11/6/2025	Richard S. Geary	EVP	Sell	33,038	$75.72	$2,501,637.36	59,657
11/5/2025	Richard S. Geary	EVP	Sell	1,601	$75.01	$120,091.01	59,657
11/3/2025	Richard S. Geary	EVP	Sell	1,680	$75.05	$126,084.00	59,657
10/31/2025	Joseph H. Wender	Director	Sell	11,200	$75.16	$841,792.00	64,035
10/31/2025	Richard S. Geary	EVP	Sell	89,249	$75.11	$6,703,492.39	59,657
10/30/2025	Joseph H. Wender	Director	Sell	16,800	$73.26	$1,230,768.00	75,235
10/16/2025	Eric Swayze	EVP	Sell	53	$73.62	$3,901.86	256
10/16/2025	Shannon L. Devers	EVP	Sell	1,263	$73.62	$92,982.06	17,494
10/15/2025	B. Lynne Parshall, Esq.	Director	Sell	5,000	$71.74	$358,700.00	61,344
10/15/2025	Brian Birchler	EVP	Sell	12,425	$72.23	$897,457.75	56,826
10/15/2025	Shannon L. Devers	EVP	Sell	6,000	$72.94	$437,640.00	15,937
10/14/2025	Brian Birchler	EVP	Sell	11,475	$72.03	$826,544.25	56,826
10/6/2025	Brett P. Monia	CEO	Sell	437	$69.26	$30,266.62	179,572
10/6/2025	Eric Swayze	EVP	Sell	6,849	$69.02	$472,717.98	30,453
10/6/2025	Patrick R. O'Neil	EVP	Sell	13,441	$69.74	$937,375.34	53,889
10/2/2025	Eric Swayze	EVP	Sell	12,972	$66.23	$859,135.56	37,302
10/2/2025	Patrick R. O'Neil	EVP	Sell	64,664	$67.69	$4,377,106.16	57,130
10/1/2025	Eric Swayze	EVP	Sell	14,142	$66.09	$934,644.78	37,302
10/1/2025	Joseph H. Wender	Director	Sell	16,800	$65.50	$1,100,400.00	92,035
9/30/2025	Elizabeth L. Hougen	EVP	Sell	49,800	$65.26	$3,249,948.00	110,500
9/30/2025	Patrick R. O'Neil	EVP	Sell	14,827	$64.68	$959,010.36	57,130
9/30/2025	Richard S. Geary	EVP	Sell	57,900	$65.24	$3,777,396.00	79,657
9/29/2025	Patrick R. O'Neil	EVP	Sell	10,473	$64.54	$675,927.42	57,130
9/12/2025	Patrick R. O'Neil	EVP	Sell	1,700	$64.58	$109,786.00	57,130
9/9/2025	Patrick R. O'Neil	EVP	Sell	21,000	$64.56	$1,355,760.00	57,130
9/5/2025	C. Frank Bennett	EVP	Sell	6,000	$59.60	$357,600.00	82,679
9/3/2025	Brett P. Monia	CEO	Sell	203,814	$60.32	$12,294,060.48	180,009
9/3/2025	C. Frank Bennett	EVP	Sell	33,909	$60.62	$2,055,563.58	101,570
9/3/2025	Eugene Schneider	EVP	Sell	19,658	$60.81	$1,195,402.98	51,507
9/3/2025	Joseph H. Wender	Director	Sell	11,200	$60.14	$673,568.00	108,835
9/3/2025	Patrick R. O'Neil	EVP	Sell	76,850	$60.97	$4,685,544.50	5,655
9/3/2025	Shannon L. Devers	EVP	Sell	3,162	$61.02	$192,945.24	15,009
9/2/2025	B. Lynne Parshall, Esq.	Director	Sell	20,000	$50.91	$1,018,200.00	66,344
9/2/2025	C. Frank Bennett	EVP	Sell	5,000	$49.14	$245,700.00	88,679
9/2/2025	Eric Swayze	EVP	Sell	11,130	$49.67	$552,827.10	37,302
9/2/2025	Joseph H. Wender	Director	Sell	16,800	$55.87	$938,616.00	120,035
9/2/2025	Patrick R. O'Neil	EVP	Sell	13,050	$54.51	$711,355.50	57,130
9/2/2025	Richard S. Geary	EVP	Sell	10,000	$50.37	$503,700.00	79,657
8/22/2025	Allene M. Diaz	Director	Sell	1,427	$42.53	$60,690.31	18,368
8/18/2025	C. Frank Bennett	EVP	Sell	10,000	$43.98	$439,800.00	93,466
8/6/2025	B. Lynne Parshall, Esq.	Director	Sell	5,000	$41.93	$209,650.00	86,344
8/5/2025	Richard S. Geary	EVP	Sell	10,000	$42.86	$428,600.00	89,492
8/4/2025	Eugene Schneider	EVP	Sell	9,549	$42.80	$408,697.20	51,507
7/30/2025	Brett P. Monia	CEO	Sell	2,432	$45.00	$109,440.00	179,820
7/11/2025	Brett P. Monia	CEO	Sell	1,160	$41.74	$48,418.40	179,820
5/1/2025	Michael R. Hayden	Director	Buy	15,000	$31.86	$477,900.00	50,219
4/16/2025	Brian Birchler	EVP	Sell	680	$28.37	$19,291.60	56,660
3/11/2025	Brett P. Monia	CEO	Sell	140	$32.32	$4,524.80	180,980
2/20/2025	Patrick R. O'Neil	EVP	Sell	1,207	$32.35	$39,046.45	56,245
2/4/2025	Brett P. Monia	CEO	Sell	38,843	$31.65	$1,229,380.95	180,683
2/4/2025	Patrick R. O'Neil	EVP	Sell	6,165	$31.62	$194,937.30	57,452
1/31/2025	Brett P. Monia	CEO	Sell	13,242	$32.45	$429,702.90	219,526
1/31/2025	Elizabeth L. Hougen	CFO	Sell	1,523	$32.44	$49,406.12	110,500
1/31/2025	Eric Swayze	EVP	Sell	1,367	$32.31	$44,167.77	48,017
1/16/2025	Brett P. Monia	CEO	Sell	33,445	$32.63	$1,091,310.35	207,396
1/16/2025	Elizabeth L. Hougen	CFO	Sell	8,870	$32.81	$291,024.70	107,885
1/16/2025	Eric Swayze	EVP	Sell	7,154	$32.84	$234,937.36	45,670
12/23/2024	Michael R. Hayden	Director	Buy	5,000	$36.22	$181,100.00	35,219
11/12/2024	Brett P. Monia	CEO	Sell	6,630	$38.05	$252,271.50	167,393
11/12/2024	Eric Swayze	EVP	Sell	1,194	$37.92	$45,276.48	33,713
10/16/2024	Eric Swayze	EVP	Sell	53	$38.31	$2,030.43	157
8/28/2024	Richard S. Geary	EVP	Sell	320	$49.16	$15,731.20	85,154
8/5/2024	Richard S. Geary	EVP	Sell	2,430	$48.00	$116,640.00	85,508
7/16/2024	Joseph Klein, III	Director	Sell	12,000	$50.00	$600,000.00	16,346
5/3/2024	Joseph Klein, III	Director	Sell	6,000	$42.71	$256,260.00	16,346
4/16/2024	Joseph Baroldi	EVP	Sell	4,006	$41.60	$166,649.60	19,631
2/16/2024	Brett P. Monia	CEO	Sell	387	$44.49	$17,217.63	173,751
2/2/2024	Brett P. Monia	CEO	Sell	23,501	$49.37	$1,160,244.37	174,138
2/2/2024	Elizabeth L. Hougen	CFO	Sell	2,125	$49.54	$105,272.50	92,905
2/2/2024	Eric Swayze	EVP	Sell	1,907	$49.56	$94,510.92	34,324
1/31/2024	Eric Swayze	EVP	Sell	10,773	$52.00	$560,196.00	32,516
1/25/2024	Brett P. Monia	CEO	Sell	2,285	$51.75	$118,248.75	151,851
1/25/2024	Patrick R. O'Neil	EVP	Sell	6,450	$51.75	$333,787.50	46,802
1/17/2024	Brett P. Monia	CEO	Sell	32,059	$50.42	$1,616,414.78	154,136
1/17/2024	Elizabeth L. Hougen	CFO	Sell	8,683	$50.42	$437,796.86	90,890
1/17/2024	Onaiza J. Cadoret-Manier	EVP	Sell	5,564	$50.42	$280,536.88	33,810
1/12/2024	Eugene Schneider	EVP	Sell	8,000	$53.50	$428,000.00	38,170
12/28/2023	B. Lynne Parshall, Esq.	Director	Sell	42,525	$50.19	$2,134,329.75	82,588
12/26/2023	B. Lynne Parshall, Esq.	Director	Sell	25,113	$51.46	$1,292,314.98	82,588
12/26/2023	Patrick R. O'Neil	EVP	Sell	20,825	$51.46	$1,071,654.50	40,355
12/21/2023	Brett P. Monia	CEO	Sell	17,500	$49.29	$862,575.00	118,111
12/20/2023	C. Frank Bennett	EVP	Sell	6,500	$49.64	$322,660.00	65,754
12/14/2023	Brett P. Monia	CEO	Sell	24,000	$49.58	$1,189,920.00	118,111
11/15/2023	Joseph Klein, III	Director	Sell	2,000	$50.00	$100,000.00	16,346
10/17/2023	Eric Swayze	EVP	Sell	52	$47.95	$2,493.40	73
10/12/2023	Brett P. Monia	CEO	Sell	3,770	$46.00	$173,420.00	118,111
9/28/2023	C. Frank Bennett	EVP	Sell	4,460	$46.50	$207,390.00	65,754
9/26/2023	B. Lynne Parshall, Esq.	Director	Sell	10,000	$45.13	$451,300.00	82,588

SEC Filings (Institutional Ownership Changes) for Ionis Pharmaceuticals (NASDAQ:IONS)

93.86% of Ionis Pharmaceuticals stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

Ionis Pharmaceuticals Institutional Trading History

Reporting Date	Hedge Fund	Shares Held	Market Value	% of Portfolio	Quarterly Change in Shares	Ownership in Company
9/9/2026	Sequoia Financial Advisors LLC	3,567	$0.28M	0.0%	N/A	0.002%
9/9/2026	Tidal Investments LLC	49,178	$3.90M	0.0%	+42.8%	0.030%
9/9/2026	MCF Advisors LLC	6,136	$0.49M	0.0%	+12,172.0%	0.004%
9/9/2026	Engineers Gate Manager LP	14,840	$1.18M	0.0%	-88.9%	0.009%
9/9/2026	Integrated Wealth Concepts LLC	2,926	$0.23M	0.0%	+7.4%	0.002%
9/9/2026	NewEdge Advisors LLC	4,822	$0.38M	0.0%	-77.9%	0.003%
9/9/2026	Squarepoint Ops LLC	109,379	$8.67M	0.0%	-84.3%	0.066%
9/8/2026	Arizona State Retirement System	43,302	$3.43M	0.0%	+2.5%	0.026%
9/8/2026	Carmignac Gestion	321,000	$25.45M	0.3%	+505.7%	0.193%
9/8/2026	Nykredit A S	6,154	$0.49M	0.0%	N/A	0.004%
8/26/2026	HighTower Advisors LLC	4,084	$0.32M	0.0%	+7.6%	0.002%
8/25/2026	VIRGINIA RETIREMENT SYSTEMS ET Al	13,400	$1.06M	0.0%	N/A	0.008%
8/22/2026	AlphaGrep UK Ltd	2,946	$0.23M	0.1%	N/A	0.002%
8/21/2026	AXQ Capital LP	10,423	$0.83M	0.1%	+171.0%	0.006%
8/21/2026	Braidwell LP	116,762	$9.26M	0.3%	-10.8%	0.070%
8/21/2026	Nykredit A S	6,154	$0.49M	0.0%	N/A	0.004%
8/20/2026	Ancora Advisors LLC	2,215	$0.18M	0.0%	-7.4%	0.001%
8/20/2026	Alyeska Investment Group L.P.	1,417,916	$112.43M	0.3%	+199.7%	0.853%
8/20/2026	Northwestern Mutual Wealth Management Co.	10,925	$0.87M	0.0%	-1.8%	0.007%
8/19/2026	Van ECK Associates Corp	63,396	$5.03M	0.0%	+83.7%	0.038%
8/19/2026	Hsbc Holdings PLC	188,402	$15.05M	0.0%	+1.3%	0.113%
8/19/2026	Archer Investment Corp	600	$48K	0.0%	N/A	0.000%
8/18/2026	North Star Asset Management Inc.	16,560	$1.31M	0.1%	N/A	0.010%
8/18/2026	Empowered Funds LLC	223,142	$17.69M	0.1%	N/A	0.134%
8/18/2026	Jefferies Financial Group Inc.	38,665	$3.07M	0.0%	N/A	0.023%
8/18/2026	Public Employees Retirement System of Ohio	46,862	$3.72M	0.0%	N/A	0.028%
8/17/2026	Corient Private Wealth LP	196,791	$15.60M	0.0%	N/A	0.118%
8/17/2026	Artia Global Partners LP	144,376	$11.45M	2.1%	N/A	0.087%
8/17/2026	Bamco Inc. NY	14,000	$1.11M	0.0%	N/A	0.008%
8/17/2026	Bank of America Corp DE	790,990	$62.72M	0.0%	N/A	0.476%
8/17/2026	Boone Capital Management LLC	519,977	$41.23M	9.6%	N/A	0.313%
8/15/2026	Freestone Grove Partners LP	339,967	$26.96M	0.2%	N/A	0.205%
8/15/2026	Jupiter Topco LLC	68,191	$5.41M	0.0%	N/A	0.041%
8/14/2026	ADAR1 Capital Management LLC	166,286	$13.19M	0.6%	N/A	0.100%
8/14/2026	Hsbc Holdings PLC	188,402	$15.05M	0.0%	N/A	0.113%
8/14/2026	EFG International AG	122,804	$9.74M	0.2%	N/A	0.074%
8/14/2026	Ancora Advisors LLC	2,215	$0.18M	0.0%	N/A	0.001%
8/14/2026	Canada Pension Plan Investment Board	33,300	$2.64M	0.0%	N/A	0.020%
8/14/2026	Legal & General Group Plc	299,184	$23.72M	0.0%	N/A	0.180%
8/14/2026	The Manufacturers Life Insurance Company	120,678	$9.57M	0.0%	N/A	0.073%
8/14/2026	Algert Global LLC	206,853	$16.40M	0.2%	+77.5%	0.124%
8/13/2026	Sanctuary Advisors LLC	3,938	$0.31M	0.0%	N/A	0.002%
8/13/2026	Polymer Capital Management HK LTD	177,897	$14.11M	0.7%	N/A	0.107%
8/13/2026	Connor Clark & Lunn Investment Management Ltd.	684,236	$54.25M	0.1%	N/A	0.412%
8/13/2026	Bank of Nova Scotia	68,548	$5.44M	0.0%	N/A	0.041%
8/12/2026	Commerce Bank	11,681	$0.93M	0.0%	N/A	0.007%
8/12/2026	Northwestern Mutual Wealth Management Co.	10,925	$0.87M	0.0%	N/A	0.007%
8/12/2026	Quantbot Technologies LP	4,812	$0.38M	0.0%	N/A	0.003%
8/12/2026	Evolve Private Wealth LLC	10,653	$0.85M	0.1%	N/A	0.006%
8/12/2026	Callan Family Office LLC	7,143	$0.57M	0.0%	N/A	0.004%
8/11/2026	Allworth Financial LP	516	$41K	0.0%	N/A	0.000%
8/11/2026	Silvant Capital Management LLC	540	$43K	0.0%	N/A	0.000%
8/11/2026	E Fund Management Co. Ltd.	5,569	$0.44M	0.0%	N/A	0.003%
8/11/2026	Edmond DE Rothschild Holding S.A.	113,320	$8.99M	0.1%	N/A	0.068%
8/10/2026	DCF Advisers LLC	37,500	$2.97M	0.5%	N/A	0.023%
8/10/2026	NewEdge Wealth LLC	8,977	$0.71M	0.0%	N/A	0.005%
8/10/2026	Eagle Health Investments LP	194,577	$15.43M	2.6%	N/A	0.117%
8/10/2026	Great Lakes Advisors LLC	66,924	$5.31M	0.0%	N/A	0.040%
8/8/2026	Meeder Advisory Services Inc.	7,660	$0.61M	0.0%	N/A	0.005%
8/7/2026	Grandfield & Dodd LLC	37,077	$2.94M	0.2%	N/A	0.022%
8/7/2026	Deutsche Bank AG	169,614	$13.45M	0.0%	N/A	0.102%
8/7/2026	Perigon Wealth Management LLC	3,477	$0.28M	0.0%	N/A	0.002%
8/7/2026	TimesSquare Capital Management LLC	614,070	$48.69M	0.7%	N/A	0.370%
8/7/2026	Mitsubishi UFJ Asset Management Co. Ltd.	2,618	$0.21M	0.0%	N/A	0.002%
8/7/2026	OneDigital Investment Advisors LLC	5,345	$0.42M	0.0%	N/A	0.003%
8/6/2026	Global Retirement Partners LLC	2,282	$0.18M	0.0%	N/A	0.001%
8/6/2026	Bank of New York Mellon Corp	542,454	$43.01M	0.0%	N/A	0.326%
8/6/2026	State of Wyoming	2,024	$0.16M	0.0%	N/A	0.001%
8/6/2026	GSA Capital Partners LLP	17,306	$1.37M	0.1%	N/A	0.010%
7/10/2026	Handelsbanken Fonder AB	383,211	$30.39M	0.1%	+79.1%	0.232%
7/8/2026	Victrix Investment Advisors	3,400	$0.27M	0.1%	N/A	0.002%
7/8/2026	Assenagon Asset Management S.A.	40,927	$3.25M	0.0%	+21.5%	0.025%
7/7/2026	GAMMA Investing LLC	2,168	$0.17M	0.0%	+22.8%	0.001%
7/7/2026	Harbor Investment Advisory LLC	1,407	$0.11M	0.0%	N/A	0.001%
6/16/2026	Empowered Funds LLC	103,141	$7.75M	0.0%	+318.1%	0.062%
6/15/2026	Carmignac Gestion	53,000	$3.98M	0.1%	N/A	0.032%
5/29/2026	Perceptive Advisors LLC	504,000	$37.85M	0.7%	N/A	0.305%
5/22/2026	Groupama Asset Managment	824,540	$61.92M	0.9%	+7.5%	0.499%
5/19/2026	Stempoint Capital LP	26,385	$1.98M	0.4%	N/A	0.016%
5/19/2026	Edgestream Partners L.P.	68,369	$5.13M	0.2%	N/A	0.041%
5/18/2026	ADAR1 Capital Management LLC	160,338	$12.04M	0.7%	+9.0%	0.097%
5/18/2026	EverSource Wealth Advisors LLC	1,794	$0.14M	0.0%	+57.8%	0.001%
5/18/2026	California State Teachers Retirement System	176,485	$13.25M	0.0%	+22.4%	0.107%
5/18/2026	Readystate Asset Management LP	20,436	$1.54M	0.1%	N/A	0.012%
5/18/2026	Empowered Funds LLC	103,141	$7.75M	0.0%	+318.1%	0.062%
5/18/2026	Eversept Partners LP	632,100	$47.46M	2.5%	+17.4%	0.382%
5/18/2026	Exome Asset Management LLC	110,064	$8.27M	4.3%	-5.5%	0.067%
5/16/2026	The Manufacturers Life Insurance Company	149,538	$11.23M	0.0%	-2.4%	0.090%
5/16/2026	Quantinno Capital Management LP	55,502	$4.17M	0.0%	+17.1%	0.034%
5/15/2026	Entropy Technologies LP	27,207	$2.04M	0.1%	N/A	0.016%
5/14/2026	Renaissance Technologies LLC	305,549	$22.94M	0.0%	+36.6%	0.185%
5/14/2026	Public Employees Retirement System of Ohio	46,030	$3.46M	0.0%	-3.3%	0.028%
5/14/2026	Arrowstreet Capital Limited Partnership	737,859	$55.41M	0.0%	-30.6%	0.446%
5/14/2026	Inceptionr LLC	16,821	$1.26M	0.3%	-5.8%	0.010%
5/13/2026	Cetera Investment Advisers	11,280	$0.85M	0.0%	+3.9%	0.007%
5/13/2026	First Trust Advisors LP	468,363	$35.17M	0.0%	-10.8%	0.283%
5/8/2026	PNC Financial Services Group Inc.	13,545	$1.02M	0.0%	-2.0%	0.008%
5/8/2026	Cassaday & Co Wealth Management LLC	400	$30K	0.0%	N/A	0.000%
5/8/2026	Amova Asset Management Americas Inc.	81,696	$6.13M	0.1%	-12.7%	0.049%
5/7/2026	Florida Financial Advisors LLC	25,886	$1.94M	0.5%	N/A	0.016%

Data available starting January 2016

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an antisense injection for the treatment of polyneuropathy caused by hereditary transthyretin amyloidosis in adults; and WAYLIVRA, an antisense medicine for treatment for familial chylomicronemia syndrome (FCS) and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of ATTR; Olezarsen for patients with FCS and severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Tofersen to inhibit the production of superoxide dismutase 1; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus. In addition, the company develops IONIS-FB-LRx to inhibit the production of complement factor B and the alternative complement pathway; and ION224 to reduce the production of diacylglycerol acyltransferase 2. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with Metagenomi, Inc, AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis, Roche, Swedish Orphan Biovitrum AB, and PTC Therapeutics. The company was incorporated in 1989 and is based in Carlsbad, California.

Today's Range

Now: $44.44

$44.27

$46.75

50 Day Range

MA: $55.97

$44.44

$63.57

52 Week Range

Now: $44.44

$44.27

$86.74

Volume

7,368,969 shs

Average Volume

3,401,087 shs

Market Capitalization

$7.39 billion

P/E Ratio

N/A

Dividend Yield

N/A

Beta

0.42

Who are the company insiders with the largest holdings of Ionis Pharmaceuticals?: Ionis Pharmaceuticals' top insider investors include:
Ionis Pharmaceuticals Inc (Major Shareholder)
Brett P Monia (CEO)
Spencer R Berthelsen (Director)
Elizabeth L Hougen (EVP)
Joseph H Wender (Director)
Elizabeth L Hougen (CFO)
Stanley T Crooke (Chairman)
B Lynne Parshall (Director)
C Frank Bennett (EVP)
Richard S Geary (EVP)
Learn More about top insider investors at Ionis Pharmaceuticals.
Who are the major institutional investors of Ionis Pharmaceuticals?: Ionis Pharmaceuticals' top institutional shareholders include:
Alyeska Investment Group L.P. — 0.85%
Bank of America Corp DE — 0.48%
Connor Clark & Lunn Investment Management Ltd. — 0.41%
TimesSquare Capital Management LLC — 0.37%
Bank of New York Mellon Corp — 0.33%
Boone Capital Management LLC — 0.31%
Learn More about top institutional investors of Ionis Pharmaceuticals stock.
Which institutional investors are selling Ionis Pharmaceuticals stock?: In the last quarter, IONS stock was sold by these institutional investors:
Squarepoint Ops LLC
Engineers Gate Manager LP
NewEdge Advisors LLC
Braidwell LP
Northwestern Mutual Wealth Management Co.
Ancora Advisors LLC
In the previous year, company insiders that have sold Ionis Pharmaceuticals company stock include:
Brett P Monia (CEO)
Spencer R Berthelsen (Director)
Elizabeth L Hougen (EVP)
C Frank Bennett (EVP)
Joseph H Wender (Director)
Richard S Geary (EVP)
Eugene Schneider (EVP)
Patrick R O'neil (EVP)
Brian Birchler (EVP)
B Lynne Parshall (Director)
Eric Swayze (EVP)
Shannon L Devers (EVP)
Kyle Jenne (EVP)
Holly B Kordasiewicz (EVP)
Allene M Diaz (Director)
Learn More investors selling Ionis Pharmaceuticals stock.
Which institutional investors are buying Ionis Pharmaceuticals stock?: During the last quarter, IONS stock was purchased by institutional investors including:
Alyeska Investment Group L.P.
Bank of America Corp DE
Connor Clark & Lunn Investment Management Ltd.
TimesSquare Capital Management LLC
Bank of New York Mellon Corp
Boone Capital Management LLC
Freestone Grove Partners LP
Legal & General Group Plc