IONS Insider Trading

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Insider Trading History
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About

Insider Ownership Percentage: 1.81%

Insider Buying (Last 12 Months): $0.00

Insider Selling (Last 12 Months): $151,774,361.84

Ionis Pharmaceuticals Insider Trading History Chart

Ionis Pharmaceuticals Share Price & Price History

^$74.12

+0.30 (1.20%)

As of 06/18/2026 04:00 PM ET

Days: 30 | 90 | 365

Ionis Pharmaceuticals Insider Trading History

Transaction Date	Insider Name	Title	Buy/Sell	Number of Shares	Average Share Price	Total Transaction	Shares Held After Transaction
6/15/2026	Spencer R. Berthelsen	Director	Sell	8,000	$73.49	$587,920.00	156,013
6/12/2026	Holly B. Kordasiewicz	EVP	Sell	60,846	$73.41	$4,466,704.86	22,458
6/1/2026	Spencer R. Berthelsen	Director	Sell	8,000	$75.67	$605,360.00	156,013
4/16/2026	Brian Birchler	EVP	Sell	973	$75.04	$73,013.92	67,500
4/16/2026	Kyle Jenne	EVP	Sell	4,902	$75.17	$368,483.34	23,713
4/15/2026	B. Lynne Parshall, Esq.	Director	Sell	5,000	$76.27	$381,350.00	51,344
4/2/2026	Shannon L. Devers	EVP	Sell	6,193	$74.05	$458,591.65	16,348
3/19/2026	Eugene Schneider	EVP	Sell	5,812	$70.97	$412,477.64	63,890
3/17/2026	Elizabeth L. Hougen	EVP	Sell	10,172	$73.21	$744,692.12	82,660
3/16/2026	Elizabeth L. Hougen	EVP	Sell	215,048	$72.40	$15,569,475.20	92,832
3/10/2026	Brett P. Monia	CEO	Sell	34,103	$75.92	$2,589,099.76	242,662
3/10/2026	Kyle Jenne	EVP	Sell	37,277	$75.85	$2,827,460.45	11,714
3/9/2026	Brett P. Monia	CEO	Sell	126,670	$75.20	$9,525,584.00	242,662
3/9/2026	Patrick R. O'Neil	EVP	Sell	10,148	$75.25	$763,637.00	62,211
3/3/2026	Allene M. Diaz	Director	Sell	54,878	$79.35	$4,354,569.30	3,811
3/3/2026	C. Frank Bennett	EVP	Sell	85,089	$79.23	$6,741,601.47	80,554
3/3/2026	Shannon L. Devers	EVP	Sell	20,106	$79.40	$1,596,416.40	22,541
2/13/2026	Eric Swayze	EVP	Sell	15,642	$81.76	$1,278,889.92	32,105
2/11/2026	B. Lynne Parshall, Esq.	Director	Sell	5,000	$82.72	$413,600.00	56,344
2/6/2026	Brett P. Monia	CEO	Sell	29,430	$85.79	$2,524,799.70	254,497
2/2/2026	C. Frank Bennett	EVP	Sell	85,089	$82.93	$7,056,430.77	80,293
1/30/2026	Brett P. Monia	CEO	Sell	62,970	$82.72	$5,208,878.40	283,927
1/30/2026	Brian Birchler	EVP	Sell	6,179	$83.03	$513,042.37	66,247
1/30/2026	C. Frank Bennett	EVP	Sell	5,885	$82.95	$488,160.75	100,293
1/30/2026	C. Frank Bennett	EVP	Sell	5,885	$82.95	$488,160.75	100,293
1/30/2026	Elizabeth L. Hougen	EVP	Sell	6,988	$83.24	$581,681.12	132,881
1/30/2026	Eric Swayze	EVP	Sell	6,179	$82.93	$512,424.47	47,747
1/30/2026	Eugene Schneider	EVP	Sell	6,179	$83.45	$515,637.55	69,702
1/30/2026	Patrick R. O'Neil	EVP	Sell	6,179	$83.53	$516,131.87	71,983
1/30/2026	Patrick R. O'Neil	EVP	Sell	6,179	$83.53	$516,131.87	71,983
1/22/2026	Shannon L. Devers	EVP	Sell	3,977	$81.34	$323,489.18	22,541
1/16/2026	Brett P. Monia	CEO	Sell	44,034	$74.82	$3,294,623.88	224,683
1/16/2026	Brian Birchler	EVP	Sell	8,480	$75.11	$636,932.80	60,435
1/16/2026	C. Frank Bennett	EVP	Sell	8,977	$75.15	$674,621.55	94,757
1/16/2026	Elizabeth L. Hougen	EVP	Sell	12,922	$75.22	$971,992.84	126,307
1/16/2026	Eric Swayze	EVP	Sell	9,884	$75.34	$744,660.56	41,935
1/16/2026	Eric Swayze	EVP	Sell	49	$75.97	$3,722.53	318
1/16/2026	Eugene Schneider	EVP	Sell	9,302	$75.59	$703,138.18	63,890
1/16/2026	Holly B. Kordasiewicz	EVP	Sell	4,141	$75.66	$313,308.06	14,718
1/16/2026	Kyle Jenne	EVP	Sell	1,823	$75.96	$138,475.08	16,389
1/16/2026	Patrick R. O'Neil	EVP	Sell	9,191	$75.84	$697,045.44	66,171
1/16/2026	Shannon L. Devers	EVP	Sell	8,353	$75.95	$634,410.35	26,518
1/7/2026	Shannon L. Devers	EVP	Sell	44,199	$85.08	$3,760,450.92	17,494
1/2/2026	Eric Swayze	EVP	Sell	23,463	$79.12	$1,856,392.56	30,453
12/1/2025	Joseph H. Wender	Director	Sell	28,000	$80.82	$2,262,960.00	36,035
11/25/2025	Shannon L. Devers	EVP	Sell	16,777	$80.91	$1,357,427.07	17,494
11/6/2025	Brian Birchler	EVP	Sell	8,000	$76.17	$609,360.00	48,826
11/6/2025	Richard S. Geary	EVP	Sell	33,038	$75.72	$2,501,637.36	59,657
11/5/2025	Richard S. Geary	EVP	Sell	1,601	$75.01	$120,091.01	59,657
11/3/2025	Richard S. Geary	EVP	Sell	1,680	$75.05	$126,084.00	59,657
10/31/2025	Joseph H. Wender	Director	Sell	11,200	$75.16	$841,792.00	64,035
10/31/2025	Richard S. Geary	EVP	Sell	89,249	$75.11	$6,703,492.39	59,657
10/30/2025	Joseph H. Wender	Director	Sell	16,800	$73.26	$1,230,768.00	75,235
10/16/2025	Eric Swayze	EVP	Sell	53	$73.62	$3,901.86	256
10/16/2025	Shannon L. Devers	EVP	Sell	1,263	$73.62	$92,982.06	17,494
10/15/2025	B. Lynne Parshall, Esq.	Director	Sell	5,000	$71.74	$358,700.00	61,344
10/15/2025	Brian Birchler	EVP	Sell	12,425	$72.23	$897,457.75	56,826
10/15/2025	Shannon L. Devers	EVP	Sell	6,000	$72.94	$437,640.00	15,937
10/14/2025	Brian Birchler	EVP	Sell	11,475	$72.03	$826,544.25	56,826
10/6/2025	Brett P. Monia	CEO	Sell	437	$69.26	$30,266.62	179,572
10/6/2025	Eric Swayze	EVP	Sell	6,849	$69.02	$472,717.98	30,453
10/6/2025	Patrick R. O'Neil	EVP	Sell	13,441	$69.74	$937,375.34	53,889
10/2/2025	Eric Swayze	EVP	Sell	12,972	$66.23	$859,135.56	37,302
10/2/2025	Patrick R. O'Neil	EVP	Sell	64,664	$67.69	$4,377,106.16	57,130
10/1/2025	Eric Swayze	EVP	Sell	14,142	$66.09	$934,644.78	37,302
10/1/2025	Joseph H. Wender	Director	Sell	16,800	$65.50	$1,100,400.00	92,035
9/30/2025	Elizabeth L. Hougen	EVP	Sell	49,800	$65.26	$3,249,948.00	110,500
9/30/2025	Patrick R. O'Neil	EVP	Sell	14,827	$64.68	$959,010.36	57,130
9/30/2025	Richard S. Geary	EVP	Sell	57,900	$65.24	$3,777,396.00	79,657
9/29/2025	Patrick R. O'Neil	EVP	Sell	10,473	$64.54	$675,927.42	57,130
9/12/2025	Patrick R. O'Neil	EVP	Sell	1,700	$64.58	$109,786.00	57,130
9/9/2025	Patrick R. O'Neil	EVP	Sell	21,000	$64.56	$1,355,760.00	57,130
9/5/2025	C. Frank Bennett	EVP	Sell	6,000	$59.60	$357,600.00	82,679
9/3/2025	Brett P. Monia	CEO	Sell	203,814	$60.32	$12,294,060.48	180,009
9/3/2025	C. Frank Bennett	EVP	Sell	33,909	$60.62	$2,055,563.58	101,570
9/3/2025	Eugene Schneider	EVP	Sell	19,658	$60.81	$1,195,402.98	51,507
9/3/2025	Joseph H. Wender	Director	Sell	11,200	$60.14	$673,568.00	108,835
9/3/2025	Patrick R. O'Neil	EVP	Sell	76,850	$60.97	$4,685,544.50	5,655
9/3/2025	Shannon L. Devers	EVP	Sell	3,162	$61.02	$192,945.24	15,009
9/2/2025	B. Lynne Parshall, Esq.	Director	Sell	20,000	$50.91	$1,018,200.00	66,344
9/2/2025	C. Frank Bennett	EVP	Sell	5,000	$49.14	$245,700.00	88,679
9/2/2025	Eric Swayze	EVP	Sell	11,130	$49.67	$552,827.10	37,302
9/2/2025	Joseph H. Wender	Director	Sell	16,800	$55.87	$938,616.00	120,035
9/2/2025	Patrick R. O'Neil	EVP	Sell	13,050	$54.51	$711,355.50	57,130
9/2/2025	Richard S. Geary	EVP	Sell	10,000	$50.37	$503,700.00	79,657
8/22/2025	Allene M. Diaz	Director	Sell	1,427	$42.53	$60,690.31	18,368
8/18/2025	C. Frank Bennett	EVP	Sell	10,000	$43.98	$439,800.00	93,466
8/6/2025	B. Lynne Parshall, Esq.	Director	Sell	5,000	$41.93	$209,650.00	86,344
8/5/2025	Richard S. Geary	EVP	Sell	10,000	$42.86	$428,600.00	89,492
8/4/2025	Eugene Schneider	EVP	Sell	9,549	$42.80	$408,697.20	51,507
7/30/2025	Brett P. Monia	CEO	Sell	2,432	$45.00	$109,440.00	179,820
7/11/2025	Brett P. Monia	CEO	Sell	1,160	$41.74	$48,418.40	179,820
5/1/2025	Michael R. Hayden	Director	Buy	15,000	$31.86	$477,900.00	50,219
4/16/2025	Brian Birchler	EVP	Sell	680	$28.37	$19,291.60	56,660
3/11/2025	Brett P. Monia	CEO	Sell	140	$32.32	$4,524.80	180,980
2/20/2025	Patrick R. O'Neil	EVP	Sell	1,207	$32.35	$39,046.45	56,245
2/4/2025	Brett P. Monia	CEO	Sell	38,843	$31.65	$1,229,380.95	180,683
2/4/2025	Patrick R. O'Neil	EVP	Sell	6,165	$31.62	$194,937.30	57,452
1/31/2025	Brett P. Monia	CEO	Sell	13,242	$32.45	$429,702.90	219,526
1/31/2025	Elizabeth L. Hougen	CFO	Sell	1,523	$32.44	$49,406.12	110,500
1/31/2025	Eric Swayze	EVP	Sell	1,367	$32.31	$44,167.77	48,017
1/16/2025	Brett P. Monia	CEO	Sell	33,445	$32.63	$1,091,310.35	207,396
1/16/2025	Elizabeth L. Hougen	CFO	Sell	8,870	$32.81	$291,024.70	107,885
1/16/2025	Eric Swayze	EVP	Sell	7,154	$32.84	$234,937.36	45,670
12/23/2024	Michael R. Hayden	Director	Buy	5,000	$36.22	$181,100.00	35,219
11/12/2024	Brett P. Monia	CEO	Sell	6,630	$38.05	$252,271.50	167,393
11/12/2024	Eric Swayze	EVP	Sell	1,194	$37.92	$45,276.48	33,713
10/16/2024	Eric Swayze	EVP	Sell	53	$38.31	$2,030.43	157
8/28/2024	Richard S. Geary	EVP	Sell	320	$49.16	$15,731.20	85,154
8/5/2024	Richard S. Geary	EVP	Sell	2,430	$48.00	$116,640.00	85,508
7/16/2024	Joseph Klein, III	Director	Sell	12,000	$50.00	$600,000.00	16,346
5/3/2024	Joseph Klein, III	Director	Sell	6,000	$42.71	$256,260.00	16,346
4/16/2024	Joseph Baroldi	EVP	Sell	4,006	$41.60	$166,649.60	19,631
2/16/2024	Brett P. Monia	CEO	Sell	387	$44.49	$17,217.63	173,751
2/2/2024	Brett P. Monia	CEO	Sell	23,501	$49.37	$1,160,244.37	174,138
2/2/2024	Elizabeth L. Hougen	CFO	Sell	2,125	$49.54	$105,272.50	92,905
2/2/2024	Eric Swayze	EVP	Sell	1,907	$49.56	$94,510.92	34,324
1/31/2024	Eric Swayze	EVP	Sell	10,773	$52.00	$560,196.00	32,516
1/25/2024	Brett P. Monia	CEO	Sell	2,285	$51.75	$118,248.75	151,851
1/25/2024	Patrick R. O'Neil	EVP	Sell	6,450	$51.75	$333,787.50	46,802
1/17/2024	Brett P. Monia	CEO	Sell	32,059	$50.42	$1,616,414.78	154,136
1/17/2024	Elizabeth L. Hougen	CFO	Sell	8,683	$50.42	$437,796.86	90,890
1/17/2024	Onaiza J. Cadoret-Manier	EVP	Sell	5,564	$50.42	$280,536.88	33,810
1/12/2024	Eugene Schneider	EVP	Sell	8,000	$53.50	$428,000.00	38,170
12/28/2023	B. Lynne Parshall, Esq.	Director	Sell	42,525	$50.19	$2,134,329.75	82,588
12/26/2023	B. Lynne Parshall, Esq.	Director	Sell	25,113	$51.46	$1,292,314.98	82,588
12/26/2023	Patrick R. O'Neil	EVP	Sell	20,825	$51.46	$1,071,654.50	40,355
12/21/2023	Brett P. Monia	CEO	Sell	17,500	$49.29	$862,575.00	118,111
12/20/2023	C. Frank Bennett	EVP	Sell	6,500	$49.64	$322,660.00	65,754
12/14/2023	Brett P. Monia	CEO	Sell	24,000	$49.58	$1,189,920.00	118,111
11/15/2023	Joseph Klein, III	Director	Sell	2,000	$50.00	$100,000.00	16,346
10/17/2023	Eric Swayze	EVP	Sell	52	$47.95	$2,493.40	73
10/12/2023	Brett P. Monia	CEO	Sell	3,770	$46.00	$173,420.00	118,111
9/28/2023	C. Frank Bennett	EVP	Sell	4,460	$46.50	$207,390.00	65,754
9/26/2023	B. Lynne Parshall, Esq.	Director	Sell	10,000	$45.13	$451,300.00	82,588
8/1/2023	Allene M. Diaz	Director	Sell	657	$41.05	$26,969.85	12,676
7/18/2023	Joseph Klein, III	Director	Sell	3,555	$42.00	$149,310.00	20,346
7/7/2023	Brett P. Monia	CEO	Sell	18,650	$42.25	$787,962.50	121,724

SEC Filings (Institutional Ownership Changes) for Ionis Pharmaceuticals (NASDAQ:IONS)

93.86% of Ionis Pharmaceuticals stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

Ionis Pharmaceuticals Institutional Trading History

Reporting Date	Hedge Fund	Shares Held	Market Value	% of Portfolio	Quarterly Change in Shares	Ownership in Company
6/16/2026	Empowered Funds LLC	103,141	$7.75M	0.0%	+318.1%	0.062%
6/15/2026	Carmignac Gestion	53,000	$3.98M	0.1%	N/A	0.032%
5/29/2026	Perceptive Advisors LLC	504,000	$37.85M	0.7%	N/A	0.305%
5/22/2026	Groupama Asset Managment	824,540	$61.92M	0.9%	+7.5%	0.499%
5/19/2026	Stempoint Capital LP	26,385	$1.98M	0.4%	N/A	0.016%
5/19/2026	Edgestream Partners L.P.	68,369	$5.13M	0.2%	N/A	0.041%
5/18/2026	ADAR1 Capital Management LLC	160,338	$12.04M	0.7%	+9.0%	0.097%
5/18/2026	EverSource Wealth Advisors LLC	1,794	$0.14M	0.0%	+57.8%	0.001%
5/18/2026	California State Teachers Retirement System	176,485	$13.25M	0.0%	+22.4%	0.107%
5/18/2026	Readystate Asset Management LP	20,436	$1.54M	0.1%	N/A	0.012%
5/18/2026	Empowered Funds LLC	103,141	$7.75M	0.0%	+318.1%	0.062%
5/18/2026	Eversept Partners LP	632,100	$47.46M	2.5%	+17.4%	0.382%
5/18/2026	Exome Asset Management LLC	110,064	$8.27M	4.3%	-5.5%	0.067%
5/16/2026	The Manufacturers Life Insurance Company	149,538	$11.23M	0.0%	-2.4%	0.090%
5/16/2026	Quantinno Capital Management LP	55,502	$4.17M	0.0%	+17.1%	0.034%
5/15/2026	Entropy Technologies LP	27,207	$2.04M	0.1%	N/A	0.016%
5/14/2026	Renaissance Technologies LLC	305,549	$22.94M	0.0%	+36.6%	0.185%
5/14/2026	Public Employees Retirement System of Ohio	46,030	$3.46M	0.0%	-3.3%	0.028%
5/14/2026	Arrowstreet Capital Limited Partnership	737,859	$55.41M	0.0%	-30.6%	0.446%
5/14/2026	Inceptionr LLC	16,821	$1.26M	0.3%	-5.8%	0.010%
5/13/2026	Cetera Investment Advisers	11,280	$0.85M	0.0%	+3.9%	0.007%
5/13/2026	First Trust Advisors LP	468,363	$35.17M	0.0%	-10.8%	0.283%
5/8/2026	PNC Financial Services Group Inc.	13,545	$1.02M	0.0%	-2.0%	0.008%
5/8/2026	Cassaday & Co Wealth Management LLC	400	$30K	0.0%	N/A	0.000%
5/8/2026	Amova Asset Management Americas Inc.	81,696	$6.13M	0.1%	-12.7%	0.049%
5/7/2026	Florida Financial Advisors LLC	25,886	$1.94M	0.5%	N/A	0.016%
5/7/2026	Dimensional Fund Advisors LP	267,215	$20.06M	0.0%	+51.8%	0.162%
5/7/2026	AlphaCentric Advisors LLC	19,587	$1.47M	1.5%	+5.7%	0.012%
5/7/2026	KBC Group NV	30,213	$2.27M	0.0%	+233.8%	0.018%
5/7/2026	SEB Asset Management AB	114,334	$8.59M	0.0%	N/A	0.069%
5/7/2026	Swiss National Bank	304,500	$22.87M	0.0%	+2.0%	0.184%
5/7/2026	ANB Bank	3,769	$0.28M	0.1%	+18.0%	0.002%
5/6/2026	California Public Employees Retirement System	255,485	$19.18M	0.0%	+19.7%	0.155%
5/6/2026	Future Fund LLC	58,732	$4.41M	1.6%	+28.1%	0.036%
5/6/2026	Assetmark Inc.	9,574	$0.72M	0.0%	+10.7%	0.006%
5/5/2026	Bank of New York Mellon Corp	514,617	$38.64M	0.0%	-31.7%	0.311%
5/5/2026	Sanctuary Advisors LLC	3,918	$0.29M	0.0%	-13.0%	0.002%
5/5/2026	Checchi Capital Advisers LLC	4,429	$0.33M	0.0%	+3.7%	0.003%
5/5/2026	Maryland State Retirement & Pension System	7,380	$0.55M	0.0%	-10.9%	0.004%
5/4/2026	Bleakley Financial Group LLC	14,316	$1.08M	0.0%	+3.2%	0.009%
5/4/2026	Principal Financial Group Inc.	7,019	$0.53M	0.0%	+110.2%	0.004%
5/4/2026	J. Safra Sarasin Holding AG	6,431	$0.48M	0.0%	-63.0%	0.004%
5/1/2026	Fifth Third Bancorp	11,011	$0.83M	0.0%	+39.6%	0.007%
5/1/2026	Candriam S.C.A.	484,053	$36.35M	0.2%	-28.6%	0.293%
4/30/2026	Hsbc Holdings PLC	185,967	$13.97M	0.0%	+590.3%	0.113%
4/30/2026	Granite Investment Partners LLC	5,345	$0.40M	0.0%	+11.2%	0.003%
4/30/2026	Sumitomo Mitsui Trust Group Inc.	81,876	$6.15M	0.0%	-12.7%	0.050%
4/30/2026	Capstone Capital Management Ltd	21,447	$1.61M	1.6%	N/A	0.013%
4/29/2026	R Squared Ltd	4,359	$0.33M	0.2%	N/A	0.003%
4/29/2026	Swedbank AB	32,253	$2.42M	0.0%	+18.3%	0.020%
4/28/2026	Cypress Capital LLC	6,000	$0.45M	0.1%	-40.0%	0.004%
4/28/2026	Stephens Inc. AR	26,761	$2.01M	0.0%	N/A	0.016%
4/28/2026	Praxis Investment Management Inc.	6,232	$0.47M	0.0%	-7.9%	0.004%
4/28/2026	QRG Capital Management Inc.	3,094	$0.23M	0.0%	N/A	0.002%
4/27/2026	Optas LLC	4,034	$0.30M	0.0%	N/A	0.002%
4/27/2026	Fideuram Intesa Sanpaolo Private Banking S.P.A.	54,269	$4.08M	0.1%	-55.4%	0.033%
4/25/2026	Strs Ohio	28,782	$2.16M	0.0%	+659.8%	0.017%
4/24/2026	Root Financial Partners LLC	681	$51K	0.0%	-49.1%	0.000%
4/22/2026	Pictet Asset Management Holding SA	1,434,995	$107.08M	0.1%	+1.2%	0.869%
4/22/2026	Sterling Capital Management LLC	1,425	$0.11M	0.0%	-16.8%	0.001%
4/22/2026	Ground Swell Capital LLC	7,285	$0.55M	1.1%	N/A	0.004%
4/21/2026	Sicart Associates LLC	159,412	$11.97M	3.1%	-2.5%	0.097%
4/20/2026	Hilton Head Capital Partners LLC	353	$27K	0.0%	-41.1%	0.000%
4/20/2026	Assenagon Asset Management S.A.	33,673	$2.53M	0.0%	+14.9%	0.020%
4/16/2026	SG Americas Securities LLC	63,295	$4.75M	0.0%	+89.5%	0.038%
3/20/2026	Hsbc Holdings PLC	26,941	$2.14M	0.0%	-40.7%	0.016%
3/17/2026	Rockefeller Capital Management L.P.	2,726	$0.22M	0.0%	+23.7%	0.002%
3/9/2026	Corient Private Wealth LLC	216,438	$17.12M	0.0%	+3,184.3%	0.131%
3/6/2026	Hsbc Holdings PLC	26,941	$2.14M	0.0%	-40.7%	0.016%
2/27/2026	Groupama Asset Managment	766,889	$60.67M	0.9%	-27.8%	0.473%
2/26/2026	Alpine Global Management LLC	53,600	$4.24M	0.7%	-4.1%	0.033%
2/19/2026	T. Rowe Price Investment Management Inc.	9,108,019	$720.54M	0.5%	-30.8%	5.623%
2/19/2026	Axxcess Wealth Management LLC	2,877	$0.23M	0.0%	N/A	0.002%
2/19/2026	Corient Private Wealth LLC	214,936	$17M	0.0%	+3,161.5%	0.133%
2/18/2026	Mercer Global Advisors Inc. ADV	5,554	$0.44M	0.0%	+48.2%	0.003%
2/18/2026	Vident Advisory LLC	10,235	$0.81M	0.0%	-11.4%	0.006%
2/18/2026	Mackenzie Financial Corp	3,891	$0.31M	0.0%	+8.4%	0.002%
2/18/2026	ADAR1 Capital Management LLC	147,130	$11.64M	0.9%	+9.9%	0.091%
2/18/2026	Empowered Funds LLC	24,671	$1.95M	0.0%	N/A	0.015%
2/18/2026	XTX Topco Ltd	16,917	$1.34M	0.0%	N/A	0.010%
2/18/2026	Zurich Insurance Group Ltd FI	261,820	$20.71M	0.1%	N/A	0.162%
2/18/2026	Voloridge Investment Management LLC	584,970	$46.28M	0.2%	-27.2%	0.361%
2/18/2026	Virtus Investment Advisers LLC	8,454	$0.67M	0.2%	-32.2%	0.005%
2/18/2026	Tudor Investment Corp ET AL	3,661	$0.29M	0.0%	N/A	0.002%
2/18/2026	Summit Securities Group LLC	748	$59K	0.0%	N/A	0.000%
2/18/2026	Janus Henderson Group PLC	68,191	$5.40M	0.0%	+6.8%	0.042%
2/18/2026	Gotham Asset Management LLC	43,212	$3.42M	0.0%	+34.4%	0.027%
2/18/2026	Engineers Gate Manager LP	22,191	$1.76M	0.0%	-13.9%	0.014%
2/18/2026	Eversept Partners LP	538,218	$42.58M	2.1%	-0.1%	0.332%
2/18/2026	Cinctive Capital Management LP	13,726	$1.09M	0.1%	-92.1%	0.008%
2/18/2026	Artia Global Partners LP	144,376	$11.42M	1.6%	+139.9%	0.089%
2/18/2026	Baker BROS. Advisors LP	1,791,841	$141.75M	0.8%	+216.1%	1.106%
2/18/2026	Bamco Inc. NY	36,000	$2.85M	0.0%	+44.0%	0.022%
2/17/2026	Guggenheim Capital LLC	37,709	$2.98M	0.0%	+6.7%	0.023%
2/17/2026	ADAR1 Capital Management LLC	147,130	$11.64M	0.8%	+9.9%	0.091%
2/17/2026	AQR Capital Management LLC	18,762	$1.48M	0.0%	+175.3%	0.012%
2/17/2026	Cetera Investment Advisers	10,856	$0.86M	0.0%	+58.0%	0.007%
2/17/2026	EFG International AG	75,276	$5.96M	0.1%	N/A	0.046%
2/17/2026	Jain Global LLC	356,259	$28.18M	0.1%	+57.8%	0.220%
2/17/2026	Quantedge Capital Pte Ltd	18,500	$1.46M	0.7%	N/A	0.011%

Data available starting January 2016

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an antisense injection for the treatment of polyneuropathy caused by hereditary transthyretin amyloidosis in adults; and WAYLIVRA, an antisense medicine for treatment for familial chylomicronemia syndrome (FCS) and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of ATTR; Olezarsen for patients with FCS and severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Tofersen to inhibit the production of superoxide dismutase 1; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus. In addition, the company develops IONIS-FB-LRx to inhibit the production of complement factor B and the alternative complement pathway; and ION224 to reduce the production of diacylglycerol acyltransferase 2. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with Metagenomi, Inc, AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis, Roche, Swedish Orphan Biovitrum AB, and PTC Therapeutics. The company was incorporated in 1989 and is based in Carlsbad, California.

Today's Range

Now: $74.12

$73.50

$75.66

50 Day Range

MA: $74.87

$71.78

$77.60

52 Week Range

Now: $74.12

$36.45

$86.74

Volume

2,984,075 shs

Average Volume

1,631,220 shs

Market Capitalization

$12.25 billion

P/E Ratio

N/A

Dividend Yield

N/A

Beta

0.37

Who are the company insiders with the largest holdings of Ionis Pharmaceuticals?: Ionis Pharmaceuticals' top insider investors include:
Ionis Pharmaceuticals Inc (Major Shareholder)
Brett P Monia (CEO)
Spencer R Berthelsen (Director)
Elizabeth L Hougen (EVP)
Joseph H Wender (Director)
Elizabeth L Hougen (CFO)
Stanley T Crooke (Chairman)
B Lynne Parshall (Director)
C Frank Bennett (EVP)
Richard S Geary (EVP)
Learn More about top insider investors at Ionis Pharmaceuticals.
Who are the major institutional investors of Ionis Pharmaceuticals?: Ionis Pharmaceuticals' top institutional shareholders include:
Pictet Asset Management Holding SA — 0.87%
Groupama Asset Managment — 0.50%
Arrowstreet Capital Limited Partnership — 0.45%
Eversept Partners LP — 0.38%
Bank of New York Mellon Corp — 0.31%
Perceptive Advisors LLC — 0.30%
Learn More about top institutional investors of Ionis Pharmaceuticals stock.
Which institutional investors are selling Ionis Pharmaceuticals stock?: In the last quarter, IONS stock was sold by these institutional investors:
Arrowstreet Capital Limited Partnership
Bank of New York Mellon Corp
Candriam S.C.A.
Fideuram Intesa Sanpaolo Private Banking S.P.A.
First Trust Advisors LP
Sumitomo Mitsui Trust Group Inc.
Amova Asset Management Americas Inc.
J. Safra Sarasin Holding AG
In the previous year, company insiders that have sold Ionis Pharmaceuticals company stock include:
Brett P Monia (CEO)
Spencer R Berthelsen (Director)
Elizabeth L Hougen (EVP)
Joseph H Wender (Director)
C Frank Bennett (EVP)
Richard S Geary (EVP)
B Lynne Parshall (Director)
Patrick R O'neil (EVP)
Eugene Schneider (EVP)
Brian Birchler (EVP)
Eric Swayze (EVP)
Shannon L Devers (EVP)
Kyle Jenne (EVP)
Holly B Kordasiewicz (EVP)
Allene M Diaz (Director)
Learn More investors selling Ionis Pharmaceuticals stock.
Which institutional investors are buying Ionis Pharmaceuticals stock?: During the last quarter, IONS stock was purchased by institutional investors including:
Perceptive Advisors LLC
Hsbc Holdings PLC
SEB Asset Management AB
Eversept Partners LP
Dimensional Fund Advisors LP
Renaissance Technologies LLC
Empowered Funds LLC
Empowered Funds LLC