| 11/17/2025 | Susquehanna International Group LLP | 16,159 | $0.26M | 0.0% | -27.9% | 0.076% |  |
| 11/17/2025 | Millennium Management LLC | 125,361 | $2.04M | 0.0% | +140.0% | 0.591% |  |
| 11/17/2025 | Foresite Capital Management V LLC | 477,078 | $7.75M | 7.1% | +17.3% | 2.248% |  |
| 11/17/2025 | Bank of America Corp DE | 4,679 | $76K | 0.0% | -80.3% | 0.022% |  |
| 11/17/2025 | Almitas Capital LLC | 577,807 | $9.38M | 2.1% | -0.4% | 2.723% |  |
| 11/14/2025 | ARCH Venture Management LLC | 2,759,072 | $44.81M | 9.1% | +51.5% | 14.362% |  |
| 11/14/2025 | Two Sigma Investments LP | 20,827 | $0.34M | 0.0% | +107.0% | 0.108% |  |
| 11/13/2025 | Takeda Pharmaceutical Co. Ltd. | 54,887 | $0.89M | 5.4% | +33.3% | 0.286% |  |
| 11/7/2025 | Vanguard Group Inc. | 779,004 | $12.65M | 0.0% | +76.0% | 4.055% |  |
| 10/14/2025 | Clarius Group LLC | 19,958 | $0.32M | 0.0% | +4.3% | 0.104% |  |
| 8/28/2025 | China Universal Asset Management Co. Ltd. | 2,966 | $26K | 0.0% | -94.9% | 0.015% |  |
| 8/15/2025 | Orland Properties Ltd | 754,698 | $6.67M | 2.8% | -95.0% | 3.929% |  |
| 8/15/2025 | MWG Management Ltd. | 1,008,116 | $8.91M | 17.2% | -95.0% | 5.248% |  |
| 8/15/2025 | HSG Holding Ltd | 152,299 | $1.35M | 0.1% | -95.0% | 0.793% |  |
| 8/15/2025 | Boothbay Fund Management LLC | 12,234 | $0.11M | 0.0% | -95.0% | 0.064% |  |
| 8/15/2025 | Bridgeway Capital Management LLC | 18,000 | $0.16M | 0.0% | N/A | 0.094% |  |
| 8/15/2025 | Bank of America Corp DE | 23,758 | $0.21M | 0.0% | -74.7% | 0.124% |  |
| 8/15/2025 | ARCH Venture Management LLC | 1,820,634 | $16.11M | 5.4% | N/A | 9.478% |  |
| 8/14/2025 | Orbimed Advisors LLC | 51,727 | $0.46M | 0.0% | N/A | 0.335% |  |
| 8/14/2025 | Raymond James Financial Inc. | 7,900 | $70K | 0.0% | -95.0% | 0.051% |  |
| 8/14/2025 | Canada Pension Plan Investment Board | 29,411 | $0.26M | 0.0% | -95.0% | 0.190% |  |
| 8/14/2025 | The Manufacturers Life Insurance Company | 24,419 | $0.22M | 0.0% | -95.2% | 0.158% |  |
| 8/14/2025 | RBF Capital LLC | 100,000 | $0.88M | 0.0% | N/A | 0.647% |  |
| 8/13/2025 | Marshall Wace LLP | 10,580 | $94K | 0.0% | N/A | 0.068% |  |
| 8/13/2025 | Walleye Capital LLC | 29,230 | $0.26M | 0.0% | N/A | 0.189% |  |
| 8/13/2025 | Decheng Capital LLC | 595,466 | $5.26M | 1.2% | -95.0% | 3.852% |  |
| 8/13/2025 | Invesco Ltd. | 12,809 | $0.11M | 0.0% | -96.6% | 0.083% |  |
| 8/12/2025 | Foresite Capital Management V LLC | 406,652 | $3.60M | 4.5% | -95.0% | 2.630% |  |
| 8/12/2025 | Foresite Capital Management IV LLC | 800,399 | $7.08M | 5.7% | -95.0% | 5.177% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 3,369 | $30K | 0.0% | -98.3% | 0.022% |  |
| 8/8/2025 | Geode Capital Management LLC | 103,270 | $0.91M | 0.0% | -97.7% | 0.668% |  |
| 8/8/2025 | Takeda Pharmaceutical Co. Ltd. | 41,165 | $0.36M | 1.9% | -95.0% | 0.266% |  |
| 8/1/2025 | Alphabet Inc. | 293,256 | $2.59M | 0.1% | -95.0% | 1.980% |  |
| 7/28/2025 | TD Asset Management Inc | 50,232 | $0.44M | 0.0% | -95.0% | 0.339% |  |
| 7/22/2025 | Johnson & Johnson | 41,165 | $0.37M | 0.1% | -95.0% | 0.278% |  |
| 7/22/2025 | Clarius Group LLC | 19,138 | $0.17M | 0.0% | -95.2% | 0.129% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 358,592 | $0.19M | 0.0% | -42.8% | 2.421% |  |
| 6/18/2025 | Voya Investment Management LLC | 50,329 | $27K | 0.0% | -4.9% | 0.340% |  |
| 5/29/2025 | Rhumbline Advisers | 235,694 | $0.13M | 0.0% | -16.2% | 0.080% |  |
| 5/21/2025 | Acadian Asset Management LLC | 660,899 | $0.35M | 0.0% | +204.2% | 0.224% |  |
| 5/19/2025 | Jane Street Group LLC | 64,241 | $35K | 0.0% | -73.2% | 0.022% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 358,592 | $0.19M | 0.0% | -42.8% | 0.121% |  |
| 5/16/2025 | Jacobs Levy Equity Management Inc. | 558,979 | $0.30M | 0.0% | -59.6% | 0.189% |  |
| 5/16/2025 | AQR Capital Management LLC | 174,279 | $94K | 0.0% | +773.5% | 0.059% |  |
| 5/16/2025 | Almitas Capital LLC | 2,482,606 | $1.34M | 0.4% | +136.3% | 0.841% |  |
| 5/12/2025 | Nuveen LLC | 641,173 | $0.35M | 0.0% | N/A | 0.217% |  |
| 5/12/2025 | Invesco Ltd. | 378,880 | $0.20M | 0.0% | -7.0% | 0.128% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 1,604,676 | $0.86M | 0.0% | -2.5% | 0.543% |  |
| 4/17/2025 | Exchange Traded Concepts LLC | 246,349 | $0.13M | 0.0% | +82.4% | 0.083% |  |
| 4/8/2025 | Rhumbline Advisers | 235,694 | $0.13M | 0.0% | -16.2% | 0.080% |  |
| 2/19/2025 | Public Employees Retirement System of Ohio | 99,307 | $64K | 0.0% | N/A | 0.034% |  |
| 2/17/2025 | venBio Partners LLC | 7,102,190 | $4.55M | 2.7% | N/A | 2.431% |  |
| 2/17/2025 | Two Sigma Investments LP | 204,501 | $0.13M | 0.0% | -15.4% | 0.070% |  |
| 2/17/2025 | Two Sigma Advisers LP | 306,400 | $0.20M | 0.0% | +143.8% | 0.105% |  |
| 2/17/2025 | Nuveen Asset Management LLC | 641,173 | $0.41M | 0.0% | -25.1% | 0.219% |  |
| 2/17/2025 | Orbimed Advisors LLC | 3,103,623 | $1.99M | 0.0% | -49.0% | 1.062% |  |
| 2/17/2025 | Millennium Management LLC | 957,507 | $0.61M | 0.0% | +34.8% | 0.328% |  |
| 2/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 308,551 | $0.20M | 0.0% | +13.4% | 0.106% |  |
| 2/17/2025 | Jacobs Levy Equity Management Inc. | 1,385,301 | $0.89M | 0.0% | N/A | 0.474% |  |
| 2/17/2025 | Graham Capital Management L.P. | 52,136 | $33K | 0.0% | N/A | 0.018% |  |
| 2/17/2025 | Foresite Capital Management V LLC | 8,133,047 | $5.21M | 4.3% | N/A | 2.784% |  |
| 2/17/2025 | D. E. Shaw & Co. Inc. | 966,265 | $0.62M | 0.0% | +104.4% | 0.331% |  |
| 2/17/2025 | BNP Paribas Financial Markets | 253,669 | $0.16M | 0.0% | N/A | 0.087% |  |
| 2/17/2025 | Almitas Capital LLC | 1,050,520 | $0.67M | 0.1% | N/A | 0.360% |  |
| 2/14/2025 | Jane Street Group LLC | 239,439 | $0.15M | 0.0% | -16.8% | 0.082% |  |
| 2/14/2025 | Northern Trust Corp | 1,310,224 | $0.84M | 0.0% | -3.4% | 0.448% |  |
| 2/14/2025 | Decheng Capital LLC | 11,909,341 | $7.62M | 1.6% | N/A | 4.076% |  |
| 2/14/2025 | Boothbay Fund Management LLC | 406,234 | $0.26M | 0.0% | +190.4% | 0.139% |  |
| 2/14/2025 | Price T Rowe Associates Inc. MD | 6,910,749 | $4.42M | 0.0% | -6.0% | 2.365% |  |
| 2/14/2025 | Johnson & Johnson | 823,317 | $0.53M | 0.1% | N/A | 0.282% |  |
| 2/13/2025 | Barclays PLC | 258,380 | $0.17M | 0.0% | +7.4% | 0.088% |  |
| 2/13/2025 | Renaissance Technologies LLC | 1,612,146 | $1.03M | 0.0% | +716.7% | 0.552% |  |
| 2/13/2025 | Wells Fargo & Company MN | 94,320 | $60K | 0.0% | +27.8% | 0.032% |  |
| 2/12/2025 | RPO LLC | 66,378 | $42K | 0.0% | N/A | 0.023% |  |
| 2/12/2025 | Geode Capital Management LLC | 4,137,264 | $2.65M | 0.0% | +2.9% | 1.416% |  |
| 2/12/2025 | Takeda Pharmaceutical Co. Ltd. | 823,317 | $0.53M | 2.0% | N/A | 0.282% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 433,265 | $0.28M | 0.0% | +347.8% | 0.148% |  |
| 2/11/2025 | Prudential Financial Inc. | 48,057 | $31K | 0.0% | -66.8% | 0.016% |  |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 1,645,787 | $1.05M | 0.0% | +43.4% | 0.563% |  |
| 1/17/2025 | SG Americas Securities LLC | 116,748 | $75K | 0.0% | +102.8% | 0.040% |  |
| 11/19/2024 | Barclays PLC | 240,615 | $0.33M | 0.0% | +312.7% | 0.082% |  |
| 11/15/2024 | Barclays PLC | 240,615 | $0.33M | 0.0% | +312.7% | 0.086% |  |
| 11/15/2024 | Jane Street Group LLC | 287,717 | $0.40M | 0.0% | +63.7% | 0.103% |  |
| 11/15/2024 | State Street Corp | 3,889,553 | $5.37M | 0.0% | +1.9% | 1.393% |  |
| 11/15/2024 | Centiva Capital LP | 22,160 | $31K | 0.0% | N/A | 0.008% |  |
| 11/15/2024 | Point72 Asia Singapore Pte. Ltd. | 37,704 | $52K | 0.0% | N/A | 0.014% |  |
| 11/15/2024 | Erste Asset Management GmbH | 54,000 | $82K | 0.0% | N/A | 0.019% |  |
| 11/14/2024 | MetLife Investment Management LLC | 36,287 | $50K | 0.0% | -57.5% | 0.013% |  |
| 11/13/2024 | FMR LLC | 1,024,583 | $1.41M | 0.0% | -62.5% | 0.367% |  |
| 11/12/2024 | Charles Schwab Investment Management Inc. | 1,147,370 | $1.58M | 0.0% | -11.6% | 0.448% |  |
| 11/9/2024 | Intech Investment Management LLC | 37,495 | $52K | 0.0% | N/A | 0.015% |  |
| 11/8/2024 | WuXi AppTec Co. Ltd. | 7,390,710 | $10.20M | 53.6% | -3.8% | 2.887% |  |
| 11/6/2024 | Cornercap Investment Counsel Inc. | 47,763 | $66K | 0.0% | -50.4% | 0.019% |  |
| 11/5/2024 | Baillie Gifford & Co. | 141,949 | $0.20M | 0.0% | -72.7% | 0.055% |  |
| 11/5/2024 | GSA Capital Partners LLP | 354,815 | $0.49M | 0.0% | +1,285.5% | 0.139% |  |
| 10/25/2024 | China Universal Asset Management Co. Ltd. | 49,238 | $68K | 0.0% | +64.4% | 0.019% |  |
| 10/10/2024 | Exchange Traded Concepts LLC | 135,050 | $0.19M | 0.0% | +37.3% | 0.053% |  |
| 10/3/2024 | SG Americas Securities LLC | 57,566 | $79K | 0.0% | +78.1% | 0.023% |  |
| 8/15/2024 | Susquehanna Fundamental Investments LLC | 128,203 | $0.19M | 0.0% | +49.5% | 0.050% |  |
| 8/15/2024 | The Manufacturers Life Insurance Company | 553,163 | $0.80M | 0.0% | +14.4% | 0.217% |  |