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PRAX Insider Trading

Insider Ownership Percentage: 3.00%
Insider Buying (Last 12 Months): $0.00
Insider Selling (Last 12 Months): $7,464,639.70

Praxis Precision Medicines Insider Trading History Chart

This chart shows the insider buying and selling history at Praxis Precision Medicines by year and by quarter.

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Praxis Precision Medicines Share Price & Price History

Current Price: $282.31
Price Change: +0.30 (1.20%)
As of 06/18/2026 04:00 PM ET

This chart shows the closing price history over time for PRAX up to the past year.

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Days: 30 | 90 | 365

Praxis Precision Medicines Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
11/20/2025Alex NemiroffGeneral CounselSell25,130$193.09$4,852,351.7020,832View SEC Filing Icon  
11/20/2025Lauren MastrocolaInsiderSell13,600$192.08$2,612,288.0010,442View SEC Filing Icon  
11/14/2024Alex NemiroffGeneral CounselSell8,239$80.20$660,767.8010,301View SEC Filing Icon  
11/14/2024Lauren MastrocolaInsiderSell5,188$81.78$424,274.645,613View SEC Filing Icon  
10/5/2023Jill DesimoneDirectorBuy966$26.25$25,357.50966View SEC Filing Icon  
6/27/2023Marcio SouzaCEOBuy666$15.90$10,589.403,000View SEC Filing Icon  
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SEC Filings (Institutional Ownership Changes) for Praxis Precision Medicines (NASDAQ:PRAX)

67.84% of Praxis Precision Medicines stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at PRAX by year and by quarter.

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Praxis Precision Medicines Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
6/3/2026Parallel Advisors LLC124$40K0.0%+3,000.0%0.000%Search for SEC Filing on Google Icon
5/29/2026Perceptive Advisors LLC2,035,986$655.97M12.8%+2.0%7.303%Search for SEC Filing on Google Icon
5/26/2026Glenmede Trust Co. NA3,410$1.10M0.0%-45.8%0.012%Search for SEC Filing on Google Icon
5/21/2026CTC Alternative Strategies Ltd.925$0.30M0.7%N/A0.003%Search for SEC Filing on Google Icon
5/20/2026Vivo Capital LLC338,895$109.19M9.1%+3.0%1.216%Search for SEC Filing on Google Icon
5/19/2026Bank of America Corp DE534,604$172.24M0.0%+2.3%1.918%Search for SEC Filing on Google Icon
5/19/2026Stempoint Capital LP56,267$18.13M3.5%+167.1%0.202%Search for SEC Filing on Google Icon
5/19/2026Janus Henderson Group PLC3,458,863$1.11B0.5%+6.8%12.406%Search for SEC Filing on Google Icon
5/19/2026Ally Bridge Group NY LLC32,810$10.57M8.5%+65.0%0.118%Search for SEC Filing on Google Icon
5/18/2026Amundi1,802$0.58M0.0%+128.1%0.006%Search for SEC Filing on Google Icon
5/18/2026California State Teachers Retirement System27,477$8.85M0.0%+39.7%0.099%Search for SEC Filing on Google Icon
5/18/2026Royal Bank of Canada4,133$1.33M0.0%+22.4%0.015%Search for SEC Filing on Google Icon
5/18/2026Exome Asset Management LLC45,469$14.65M7.6%-21.8%0.163%Search for SEC Filing on Google Icon
5/16/2026The Manufacturers Life Insurance Company 30,093$9.70M0.0%-9.6%0.108%Search for SEC Filing on Google Icon
5/16/2026Quantinno Capital Management LP3,320$1.07M0.0%+21.9%0.012%Search for SEC Filing on Google Icon
5/16/2026SummitTX Capital L.P.36,838$11.87M0.4%-11.5%0.132%Search for SEC Filing on Google Icon
5/16/2026ABS Direct Equity Fund LLC400$0.14M0.1%N/A0.001%Search for SEC Filing on Google Icon
5/16/2026Orbimed Advisors LLC172,500$55.58M1.0%+82.5%0.619%Search for SEC Filing on Google Icon
5/15/2026Affinity Asset Advisors LLC170,000$54.77M2.8%-8.1%0.610%Search for SEC Filing on Google Icon
5/14/2026Sei Investments Co.29,525$9.51M0.0%+86.9%0.106%Search for SEC Filing on Google Icon
5/13/2026First Trust Advisors LP33,335$10.74M0.0%-62.4%0.120%Search for SEC Filing on Google Icon
5/8/2026PNC Financial Services Group Inc.953$0.31M0.0%+33.5%0.003%Search for SEC Filing on Google Icon
5/7/2026Carl P. Sherr & Co. LLC972$0.31M0.1%+8.4%0.003%Search for SEC Filing on Google Icon
5/7/2026Dimensional Fund Advisors LP31,161$10.04M0.0%+32.4%0.112%Search for SEC Filing on Google Icon
5/7/2026Parallel Advisors LLC124$40K0.0%+3,000.0%0.000%Search for SEC Filing on Google Icon
5/7/2026KBC Group NV715$0.23M0.0%+5.8%0.003%Search for SEC Filing on Google Icon
5/7/2026Swiss National Bank46,700$15.05M0.0%+15.3%0.168%Search for SEC Filing on Google Icon
5/6/2026California Public Employees Retirement System42,163$13.58M0.0%N/A0.151%Search for SEC Filing on Google Icon
5/6/2026Allspring Global Investments Holdings LLC8,536$2.73M0.0%+392.8%0.031%Search for SEC Filing on Google Icon
5/5/2026Bank of New York Mellon Corp87,047$28.05M0.0%+11.7%0.313%Search for SEC Filing on Google Icon
5/4/2026Principal Financial Group Inc.1,153$0.37M0.0%+15.9%0.004%Search for SEC Filing on Google Icon
5/4/2026Chicago Partners Investment Group LLC833$0.28M0.0%N/A0.003%Search for SEC Filing on Google Icon
5/1/2026Fifth Third Bancorp3,589$1.16M0.0%N/A0.013%Search for SEC Filing on Google Icon
5/1/2026Candriam S.C.A.63,628$20.50M0.1%-42.5%0.228%Search for SEC Filing on Google Icon
4/30/2026Hsbc Holdings PLC1,634$0.52M0.0%+98.1%0.006%Search for SEC Filing on Google Icon
4/28/2026Abel Hall LLC1,392$0.45M0.1%+34.9%0.005%Search for SEC Filing on Google Icon
4/25/2026Strs Ohio3,600$1.16M0.0%+12.5%0.013%Search for SEC Filing on Google Icon
4/22/2026Pictet Asset Management Holding SA286,644$91.43M0.1%+19.1%1.029%Search for SEC Filing on Google Icon
4/22/2026Sterling Capital Management LLC804$0.26M0.0%-33.6%0.003%Search for SEC Filing on Google Icon
4/21/2026Pinnacle Wealth Management Advisory Group LLC744$0.24M0.0%N/A0.003%Search for SEC Filing on Google Icon
4/16/2026SG Americas Securities LLC852$0.28M0.0%-91.5%0.003%Search for SEC Filing on Google Icon
3/20/2026Hsbc Holdings PLC825$0.24M0.0%-92.6%0.003%Search for SEC Filing on Google Icon
2/26/2026Seven Fleet Capital Management LP2,700$0.80M0.6%N/A0.010%Search for SEC Filing on Google Icon
2/19/2026T. Rowe Price Investment Management Inc.276,392$81.46M0.1%N/A1.097%Search for SEC Filing on Google Icon
2/19/2026Invesco Ltd.77,088$22.72M0.0%+269.4%0.306%Search for SEC Filing on Google Icon
2/18/2026Mercer Global Advisors Inc. ADV1,212$0.36M0.0%N/A0.005%Search for SEC Filing on Google Icon
2/18/2026Mackenzie Financial Corp1,399$0.42M0.0%N/A0.006%Search for SEC Filing on Google Icon
2/18/2026Coastal Bridge Advisors LLC4,154$1.22M0.1%+8.0%0.016%Search for SEC Filing on Google Icon
2/18/2026KVP Capital Advisors LP42,900$12.64M12.2%N/A0.170%Search for SEC Filing on Google Icon
2/18/2026Ikarian Capital LLC86,581$25.52M2.0%-32.7%0.344%Search for SEC Filing on Google Icon
2/18/2026Virtus Investment Advisers LLC989$0.29M0.1%-60.9%0.004%Search for SEC Filing on Google Icon
2/18/2026Wellington Management Group LLP176,562$52.04M0.0%+188.3%0.701%Search for SEC Filing on Google Icon
2/18/2026SummitTX Capital L.P.41,629$12.27M0.4%+19.2%0.165%Search for SEC Filing on Google Icon
2/18/2026Readystate Asset Management LP36,792$10.84M0.4%-66.3%0.146%Search for SEC Filing on Google Icon
2/18/2026Orbimed Advisors LLC94,500$27.85M0.6%N/A0.375%Search for SEC Filing on Google Icon
2/18/2026Perceptive Advisors LLC1,995,986$588.30M10.5%+27.6%7.924%Search for SEC Filing on Google Icon
2/18/2026Man Group plc21,170$6.24M0.0%N/A0.084%Search for SEC Filing on Google Icon
2/18/2026Ishara Investments LP40,000$11.79M13.6%N/A0.159%Search for SEC Filing on Google Icon
2/18/2026Janus Henderson Group PLC3,240,086$954.83M0.4%+17.2%12.863%Search for SEC Filing on Google Icon
2/18/2026Cormorant Asset Management LP950,000$280M12.9%-5.0%3.771%Search for SEC Filing on Google Icon
2/18/2026Artia Global Partners LP2,500$0.74M0.1%N/A0.010%Search for SEC Filing on Google Icon
2/18/2026Baker BROS. Advisors LP1,126,488$332.02M1.9%+63.4%4.472%Search for SEC Filing on Google Icon
2/18/2026Boothbay Fund Management LLC20,974$6.18M0.1%-78.2%0.083%Search for SEC Filing on Google Icon
2/18/2026ACT Capital Management LLC700$0.21M0.2%N/A0.003%Search for SEC Filing on Google Icon
2/17/2026Logos Global Management LP375,000$110.53M6.7%+200.0%1.489%Search for SEC Filing on Google Icon
2/17/2026ADAR1 Capital Management LLC1,500$0.44M0.0%N/A0.006%Search for SEC Filing on Google Icon
2/17/2026Burkehill Global Management LP25,000$7.37M0.5%N/A0.099%Search for SEC Filing on Google Icon
2/17/2026AQR Capital Management LLC28,828$8.50M0.0%+31.6%0.114%Search for SEC Filing on Google Icon
2/17/2026Abel Hall LLC1,032$0.30M0.1%N/A0.004%Search for SEC Filing on Google Icon
2/17/2026Ally Bridge Group NY LLC19,882$5.86M6.1%-80.1%0.079%Search for SEC Filing on Google Icon
2/17/2026RA Capital Management L.P.373,787$110.17M1.1%N/A1.484%Search for SEC Filing on Google Icon
2/17/2026ArrowMark Colorado Holdings LLC30,000$8.84M0.2%N/A0.119%Search for SEC Filing on Google Icon
2/17/2026Trexquant Investment LP8,331$2.46M0.0%-6.4%0.033%Search for SEC Filing on Google Icon
2/17/2026Amundi790$0.23M0.0%N/A0.003%Search for SEC Filing on Google Icon
2/17/2026Orbis Allan Gray Ltd1,255,162$369.95M1.6%N/A4.983%Search for SEC Filing on Google Icon
2/17/2026Price T Rowe Associates Inc. MD785,987$231.66M0.0%-21.7%3.120%Search for SEC Filing on Google Icon
2/17/2026T. Rowe Price Investment Management Inc.18,018$5.31M0.0%N/A0.072%Search for SEC Filing on Google Icon
2/17/2026Integral Health Asset Management LLC40,000$11.79M0.6%N/A0.159%Search for SEC Filing on Google Icon
2/17/2026Adage Capital Partners GP L.L.C.965,313$284.52M0.4%-59.3%3.832%Search for SEC Filing on Google Icon
2/17/2026California State Teachers Retirement System19,671$5.80M0.0%+5.9%0.078%Search for SEC Filing on Google Icon
2/17/2026Russell Investments Group Ltd.20,612$6.08M0.0%+368.0%0.082%Search for SEC Filing on Google Icon
2/17/2026B Group Inc.33,237$9.80M7.2%+5.5%0.132%Search for SEC Filing on Google Icon
2/17/2026Atom Investors LP16,487$4.86M0.4%N/A0.065%Search for SEC Filing on Google Icon
2/17/2026State of Wisconsin Investment Board15,231$4.49M0.0%+68.6%0.060%Search for SEC Filing on Google Icon
2/17/2026Royal Bank of Canada3,378$1M0.0%-14.6%0.013%Search for SEC Filing on Google Icon
2/17/2026Opal Capital LLC996$0.32M0.1%N/A0.004%Search for SEC Filing on Google Icon
2/16/2026Squarepoint Ops LLC1,890$0.56M0.0%N/A0.008%Search for SEC Filing on Google Icon
2/16/2026Sofinnova Investments Inc.125,722$37.06M1.5%-27.3%0.499%Search for SEC Filing on Google Icon
2/16/2026Public Employees Retirement Association of Colorado2,390$0.70M0.0%+1,001.4%0.009%Search for SEC Filing on Google Icon
2/16/2026MML Investors Services LLC864$0.26M0.0%N/A0.003%Search for SEC Filing on Google Icon
2/16/2026First Turn Management LLC35,749$10.54M1.2%N/A0.142%Search for SEC Filing on Google Icon
2/16/2026Healthcare of Ontario Pension Plan Trust Fund4,587$1.35M0.0%N/A0.018%Search for SEC Filing on Google Icon
2/16/2026Eventide Asset Management LLC67,100$19.78M0.3%N/A0.266%Search for SEC Filing on Google Icon
2/16/2026Barclays PLC530,751$156.43M0.0%+592.6%2.107%Search for SEC Filing on Google Icon
2/13/2026Kestra Advisory Services LLC1,180$0.35M0.0%N/A0.005%Search for SEC Filing on Google Icon
2/13/2026Marshall Wace LLP69,242$20.41M0.0%+1.6%0.275%Search for SEC Filing on Google Icon
2/13/2026The Manufacturers Life Insurance Company 33,291$9.86M0.0%-7.1%0.132%Search for SEC Filing on Google Icon
2/13/2026Quinn Opportunity Partners LLC2,000$0.59M0.0%N/A0.008%Search for SEC Filing on Google Icon
2/13/2026Walleye Capital LLC3,587$1.06M0.0%N/A0.014%Search for SEC Filing on Google Icon
2/13/2026Affinity Asset Advisors LLC185,000$54.53M3.1%N/A0.734%Search for SEC Filing on Google Icon
Data available starting January 2016

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Praxis Precision Medicines logo
Praxis Precision Medicines, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for central nervous system disorders characterized by neuronal excitation-inhibition imbalance. It is developing ulixacaltamide, a small molecule inhibitor of T-type calcium channels that is in Phase III clinical trial for the treatment of essential tremor; PRAX-562 for the treatment of pediatric patients with developmental and epileptic encephalopathies (DEE); and PRAX-628 to treat focal epilepsy. The company also develops PRAX-222 for the treatment of pediatric patients with early-onset SCN2A-DEE; PRAX-020 to treat KCNT1 related epilepsies; PRAX-080 for the treatment of PCDH19; and PRAX-090 and PRAX-100 for SYNGAP1 and SCN2A-LoF. It has a license agreement with RogCon Inc.; a research collaboration and license agreement with Ionis Pharmaceuticals, Inc.; a strategic collaboration and license agreement with UCB Biopharma SRL; and collaboration with The Florey Institute to develop three novel ASOs. The company was incorporated in 2015 and is based in Boston, Massachusetts.
Read More on Praxis Precision Medicines

Today's Range

Now: $282.31
Low: $274.16
High: $289.67

50 Day Range

MA: $315.29
Low: $240.66
High: $357.13

52 Week Range

Now: $282.31
Low: $37.19
High: $366.52

Volume

684,321 shs

Average Volume

523,564 shs

Market Capitalization

$7.87 billion

P/E Ratio

N/A

Dividend Yield

N/A

Beta

2.71

Who are the company insiders with the largest holdings of Praxis Precision Medicines?

Praxis Precision Medicines' top insider investors include:
  1. Alex Nemiroff (General Counsel)
  2. Marcio Souza (CEO)
  3. Lauren Mastrocola (Insider)
  4. Dean J Mitchell (Director)
  5. Timothy Edwin Kelly (CFO)
  6. Jill Desimone (Director)
  7. Parallel Master Fund LP Bsof (Major Shareholder)
Learn More about top insider investors at Praxis Precision Medicines.

Who are the major institutional investors of Praxis Precision Medicines?

Praxis Precision Medicines' top institutional investors include:
  1. Janus Henderson Group PLC — 12.41%
  2. Perceptive Advisors LLC — 7.30%
  3. Bank of America Corp DE — 1.92%
  4. Vivo Capital LLC — 1.22%
  5. Pictet Asset Management Holding SA — 1.03%
  6. Orbimed Advisors LLC — 0.62%
Learn More about top institutional investors of Praxis Precision Medicines stock.

Which major investors are selling Praxis Precision Medicines stock?

In the last quarter, PRAX stock was sold by these institutional investors:
  1. First Trust Advisors LP
  2. Candriam S.C.A.
  3. Affinity Asset Advisors LLC
  4. Exome Asset Management LLC
  5. SG Americas Securities LLC
  6. SummitTX Capital L.P.
  7. The Manufacturers Life Insurance Company
  8. Glenmede Trust Co. NA
During the previous year, company insiders that have sold Praxis Precision Medicines company stock include:
  1. Alex Nemiroff (General Counsel)
  2. Lauren Mastrocola (Insider)
Learn More investors selling Praxis Precision Medicines stock.

Which major investors are buying Praxis Precision Medicines stock?

During the previous quarter, PRAX stock was bought by institutional investors including:
  1. Janus Henderson Group PLC
  2. Orbimed Advisors LLC
  3. Pictet Asset Management Holding SA
  4. California Public Employees Retirement System
  5. Perceptive Advisors LLC
  6. Stempoint Capital LP
  7. Sei Investments Co.
  8. Ally Bridge Group NY LLC

Praxis Precision Medicines Active Insiders

Marcio Souza
Marcio Souza (Age 47)
CEO
Jill Desimone
Jill Desimone
Director
Alex Nemiroff
Alex Nemiroff (Age 47)
General Counsel
Lauren Mastrocola
Lauren Mastrocola
Insider