SPRO Insider Trading

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Insider Trading History
Frequently Asked Questions
About

Insider Ownership Percentage: 5.50%

Insider Buying (Last 12 Months): $0.00

Insider Selling (Last 12 Months): $299,674.72

Spero Therapeutics Insider Trading History Chart

Spero Therapeutics Share Price & Price History

^$2.28

+0.30 (1.20%)

As of 12/4/2025 05:00 PM ET

Days: 30 | 90 | 365

Spero Therapeutics Insider Trading History

Transaction Date	Insider Name	Title	Buy/Sell	Number of Shares	Average Share Price	Total Transaction	Shares Held After Transaction
11/7/2025	Esther Rajavelu	Insider	Sell	40,270	$2.37	$95,439.90	869,450
8/28/2025	Ankit Mahadevia	Director	Sell	6,572	$1.97	$12,946.84	703,294
2/5/2025	Ankit Mahadevia	Director	Sell	69,219	$0.78	$53,990.82	689,866
2/5/2025	Esther Rajavelu	CFO	Sell	20,689	$0.78	$16,137.42	724,720
2/5/2025	Sath Shukla	CEO	Sell	155,333	$0.78	$121,159.74	1,736,883
8/27/2024	Ankit Mahadevia	Director	Sell	5,912	$1.35	$7,981.20	759,085
8/27/2024	Sath Shukla	CEO	Sell	2,757	$1.35	$3,721.95	1,140,809
8/27/2024	Timothy Keutzer	COO	Sell	2,213	$1.35	$2,987.55	531,837
8/5/2024	Sath Shukla	CEO	Sell	17,641	$1.31	$23,109.71	1,143,566
8/2/2024	Sath Shukla	CEO	Sell	14,800	$1.32	$19,536.00	1,161,207
9/13/2023	Kamal Hamed	Insider	Sell	39,496	$1.27	$50,159.92	576,461
8/29/2023	Sath Shukla	CEO	Sell	4,163	$1.30	$5,411.90	572,500
8/28/2023	Ankit Mahadevia	Director	Sell	9,040	$1.26	$11,390.40	788,792
8/28/2023	Timothy Keutzer	Insider	Sell	1,854	$1.26	$2,336.04	325,290
2/3/2023	Ankit Mahadevia	CEO	Sell	12,286	$1.81	$22,237.66	797,832
2/2/2023	Sath Shukla	CFO	Sell	9,504	$1.83	$17,392.32	312,517
2/2/2023	Timothy Keutzer	COO	Sell	3,394	$1.86	$6,312.84	327,144

SEC Filings (Institutional Ownership Changes) for Spero Therapeutics (NASDAQ:SPRO)

25.60% of Spero Therapeutics stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

Spero Therapeutics Institutional Trading History

Reporting Date	Hedge Fund	Shares Held	Market Value	% of Portfolio	Quarterly Change in Shares	Ownership in Company
11/17/2025	Ionic Capital Management LLC	208,725	$0.39M	0.0%	+39.2%	0.370%
11/17/2025	Anson Funds Management LP	1,603,569	$3.02M	0.2%	-0.7%	2.846%
11/14/2025	ADAR1 Capital Management LLC	115,539	$0.22M	0.0%	-19.7%	0.205%
11/14/2025	Shay Capital LLC	63,667	$0.12M	0.0%	N/A	0.113%
11/14/2025	Two Sigma Investments LP	49,399	$93K	0.0%	N/A	0.088%
11/13/2025	Arrowstreet Capital Limited Partnership	150,516	$0.28M	0.0%	N/A	0.267%
11/12/2025	Dimensional Fund Advisors LP	28,994	$55K	0.0%	N/A	0.052%
11/7/2025	GSA Capital Partners LLP	106,894	$0.20M	0.0%	N/A	0.190%
11/7/2025	Vanguard Group Inc.	1,989,855	$3.74M	0.0%	+2.0%	3.536%
10/7/2025	Assenagon Asset Management S.A.	36,993	$70K	0.0%	N/A	0.066%
8/15/2025	Bridgeway Capital Management LLC	114,800	$0.33M	0.0%	-25.8%	0.204%
8/13/2025	Stonepine Capital Management LLC	156,888	$0.46M	0.4%	N/A	0.281%
8/13/2025	Invesco Ltd.	14,968	$43K	0.0%	N/A	0.027%
8/13/2025	Quadrature Capital Ltd	31,205	$90K	0.0%	N/A	0.056%
8/12/2025	XTX Topco Ltd	34,551	$100K	0.0%	N/A	0.062%
8/8/2025	Geode Capital Management LLC	510,699	$1.48M	0.0%	-2.7%	0.913%
7/28/2025	Axxcess Wealth Management LLC	32,548	$94K	0.0%	N/A	0.058%
7/7/2025	Capital Asset Advisory Services LLC	32,548	$94K	0.0%	N/A	0.058%
5/28/2025	Anson Funds Management LP	3,798,932	$2.74M	0.4%	-1.1%	6.795%
5/21/2025	Acadian Asset Management LLC	871,212	$0.63M	0.0%	-16.2%	1.558%
5/14/2025	Anson Funds Management LP	7,638,818	$5.50M	0.8%	+98.9%	13.662%
5/7/2025	Mackenzie Financial Corp	209,031	$0.15M	0.0%	+11.4%	0.374%
2/20/2025	Mackenzie Financial Corp	187,559	$0.19M	0.0%	+487.9%	0.344%
2/17/2025	Squarepoint Ops LLC	55,051	$57K	0.0%	N/A	0.101%
2/17/2025	Anson Funds Management LP	3,839,886	$3.96M	0.4%	+2.4%	7.043%
2/14/2025	Jane Street Group LLC	52,869	$54K	0.0%	N/A	0.097%
2/14/2025	Northern Trust Corp	86,447	$89K	0.0%	-22.5%	0.159%
2/14/2025	Three Seasons Wealth LLC	30,000	$31K	0.0%	N/A	0.055%
2/13/2025	XTX Topco Ltd	30,138	$31K	0.0%	N/A	0.055%
2/13/2025	Renaissance Technologies LLC	1,105,591	$1.14M	0.0%	+13.4%	2.028%
2/13/2025	ADAR1 Capital Management LLC	801,277	$0.83M	0.2%	+7.8%	1.470%
2/12/2025	JPMorgan Chase & Co.	61,624	$63K	0.0%	+26,011.9%	0.113%
2/11/2025	Prudential Financial Inc.	49,200	$51K	0.0%	N/A	0.090%
2/11/2025	Virtu Financial LLC	46,046	$47K	0.0%	N/A	0.084%
2/10/2025	Monimus Capital Management LP	310,908	$0.32M	0.3%	N/A	0.570%
2/6/2025	Atlas Venture Life Science Advisors LLC	305,255	$0.31M	0.0%	-24.2%	0.560%
11/16/2024	Geode Capital Management LLC	481,187	$0.65M	0.0%	-2.2%	0.891%
8/9/2024	Renaissance Technologies LLC	975,952	$1.27M	0.0%	+14.2%	1.808%
8/9/2024	Atlas Venture Life Science Advisors LLC	535,336	$0.70M	0.1%	-11.9%	0.992%
8/6/2024	Acadian Asset Management LLC	1,071,860	$1.39M	0.0%	+40.6%	1.985%
5/20/2024	Virtu Financial LLC	18,180	$31K	0.0%	N/A	0.034%
5/16/2024	Murchinson Ltd.	873,910	$1.50M	0.1%	+1.3%	1.622%
5/14/2024	Anson Funds Management LP	3,750,450	$6.45M	0.4%	-12.7%	6.959%
5/10/2024	Acadian Asset Management LLC	762,598	$1.31M	0.0%	+121.8%	1.415%
5/10/2024	Vanguard Group Inc.	1,653,432	$2.84M	0.0%	+0.6%	3.068%
5/6/2024	Atlas Venture Life Science Advisors LLC	607,613	$1.05M	0.1%	-40.0%	1.128%
2/14/2024	ADAR1 Capital Management LLC	1,067,711	$1.57M	0.6%	N/A	2.015%
11/15/2023	Rock Springs Capital Management LP	57,373	$69K	0.0%	-91.4%	0.109%
11/14/2023	AWM Investment Company Inc.	333,400	$0.40M	0.1%	-13.0%	0.632%
11/13/2023	Acadian Asset Management LLC	272,024	$0.33M	0.0%	+56.8%	0.516%
8/14/2023	Anson Funds Management LP	3,444,862	$5M	0.8%	+3.0%	6.537%
8/11/2023	AWM Investment Company Inc.	383,400	$0.56M	0.1%	-70.5%	0.729%
8/11/2023	Atlas Venture Life Science Advisors LLC	1,013,438	$1.47M	0.2%	-1.7%	1.928%
8/7/2023	Acadian Asset Management LLC	173,539	$0.25M	0.0%	N/A	0.330%
8/7/2023	Royce & Associates LP	22,851	$33K	0.0%	N/A	0.043%
8/3/2023	Mackenzie Financial Corp	17,198	$25K	0.0%	N/A	0.033%
7/27/2023	Virtu Financial LLC	22,195	$32K	0.0%	N/A	0.042%
5/15/2023	Anson Funds Management LP	3,344,862	$4.85M	0.8%	+10.8%	6.363%
4/17/2023	Bourgeon Capital Management LLC	25,600	$37K	0.0%	+95.4%	0.049%
2/14/2023	AWM Investment Company Inc.	1,300,400	$2.25M	0.3%	-43.5%	3.708%
11/16/2022	Alphabet Inc.	889,979	$1.78M	0.1%	N/A	2.538%
11/16/2022	Anson Funds Management LP	1,473,872	$2.95M	0.3%	N/A	4.203%
11/15/2022	Murchinson Ltd.	762,700	$1.53M	0.4%	N/A	2.175%
11/15/2022	BVF Inc. IL	1,929,376	$3.86M	0.2%	-37.6%	5.501%
10/21/2022	Weitzel Financial Services Inc.	14,200	$28K	0.0%	N/A	0.040%
8/9/2022	Kingsbury Capital Investment Advisors LLC	60,844	$45K	0.1%	N/A	0.185%
7/27/2022	Assenagon Asset Management S.A.	131,020	$97K	0.0%	+466.6%	0.399%
5/17/2022	Rock Springs Capital Management LP	990,913	$8.62M	0.2%	+4.8%	3.025%
5/16/2022	Eversept Partners LP	59,639	$0.52M	0.0%	N/A	0.182%
5/16/2022	Granahan Investment Management LLC	113,322	$0.99M	0.0%	-70.1%	0.346%
5/11/2022	GSA Capital Partners LLP	25,916	$0.23M	0.0%	N/A	0.079%
5/6/2022	Sentinel Pension Advisors Inc.	42,000	$0.37M	0.1%	+39.1%	0.128%
5/5/2022	New York State Common Retirement Fund	17,123	$0.15M	0.0%	-68.1%	0.052%
5/3/2022	Bourgeon Capital Management LLC	63,096	$0.55M	0.1%	+23.1%	0.193%
4/25/2022	Assenagon Asset Management S.A.	23,123	$0.20M	0.0%	N/A	0.071%
2/14/2022	Williams Jones Wealth Management LLC.	75,000	$1.20M	0.0%	-28.9%	0.232%
2/10/2022	Rafferty Asset Management LLC	34,958	$0.56M	0.0%	+86.1%	0.108%
2/9/2022	BNP Paribas Arbitrage SA	8,997	$0.14M	0.0%	+107.2%	0.028%
2/9/2022	Dimensional Fund Advisors LP	371,222	$5.94M	0.0%	+12.6%	1.148%
2/8/2022	Sentinel Pension Advisors Inc.	30,200	$0.48M	0.2%	+49.5%	0.093%
2/8/2022	Northern Trust Corp	253,200	$4.05M	0.0%	-1.8%	0.783%
2/4/2022	IndexIQ Advisors LLC	28,689	$0.46M	0.0%	-6.1%	0.089%
2/3/2022	OUP Management Co. LLC	249,070	$3.99M	1.8%	N/A	0.771%
2/2/2022	New York State Common Retirement Fund	53,728	$0.86M	0.0%	-24.6%	0.166%
1/31/2022	Bourgeon Capital Management LLC	51,246	$0.82M	0.2%	+22.8%	0.159%
1/28/2022	Allspring Global Investments Holdings LLC	10,186	$0.16M	0.0%	N/A	0.032%
1/21/2022	Russell Investments Group Ltd.	7,250	$0.12M	0.0%	-11.0%	0.022%
1/10/2022	Patriot Financial Group Insurance Agency LLC	4,150	$66K	0.0%	N/A	0.013%
11/16/2021	BVF Inc. IL	1,809,352	$33.31M	1.3%	-15.4%	5.628%
11/15/2021	Rock Springs Capital Management LP	941,543	$17.33M	0.4%	-2.5%	2.929%
11/15/2021	Royal Bank of Canada	180,102	$3.32M	0.0%	+8,249.7%	0.560%
11/15/2021	Granahan Investment Management Inc. MA	555,614	$10.23M	0.2%	+67.0%	1.728%
11/15/2021	Dimensional Fund Advisors LP	329,633	$6.07M	0.0%	-12.0%	1.025%
11/12/2021	Brandywine Global Investment Management LLC	58,400	$1.08M	0.0%	N/A	0.182%
11/12/2021	The Manufacturers Life Insurance Company	14,276	$0.26M	0.0%	-10.4%	0.044%
11/12/2021	Geode Capital Management LLC	444,914	$8.19M	0.0%	+7.5%	1.384%
11/10/2021	Goldman Sachs Group Inc.	137,579	$2.53M	0.0%	+1.0%	0.428%
11/10/2021	IndexIQ Advisors LLC	30,543	$0.56M	0.0%	+11.1%	0.095%
11/10/2021	Citigroup Inc.	16,085	$0.30M	0.0%	-59.1%	0.050%
11/10/2021	Rafferty Asset Management LLC	18,789	$0.35M	0.0%	-21.4%	0.058%

Data available starting January 2016

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying, developing, and commercializing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adults; SPR206, an intravenous-administered antibiotic against MDR Gram-negative pathogens comprising carbapenem-resistant enterobacterales (CRE), acinetobacter baumannii, and pseudomonas aeruginosa, as well as negative bacterial infections in the hospital setting; and SPR720, a novel oral antibiotic agent for the treatment of non-tuberculous mycobacterial pulmonary disease. It has license agreement with Meiji Seika Pharma Co., Ltd. to support the development of tebipenem HBr; Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries; and Vertex Pharmaceuticals Incorporated for patents relating to SPR720, as well as SPR719, an active metabolite. Spero Therapeutics, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.

Today's Range

Now: $2.28

$2.24

$2.33

50 Day Range

MA: $2.30

$1.88

$2.66

52 Week Range

Now: $2.28

$0.51

$3.22

Volume

241,589 shs

Average Volume

444,473 shs

Market Capitalization

$128.46 million

P/E Ratio

N/A

Dividend Yield

N/A

Beta

1.48

Who are the company insiders with the largest holdings of Spero Therapeutics?: Spero Therapeutics' top insider investors include:
Sath Shukla (CEO)
Esther Rajavelu (Insider)
Ankit Mahadevia (Director)
Esther Rajavelu (CFO)
Timothy Keutzer (COO)
Learn More about top insider investors at Spero Therapeutics.
Who are the major institutional investors of Spero Therapeutics?: Spero Therapeutics' top institutional shareholders include:
Vanguard Group Inc. — 3.54%
Anson Funds Management LP — 2.85%
Ionic Capital Management LLC — 0.37%
Arrowstreet Capital Limited Partnership — 0.27%
ADAR1 Capital Management LLC — 0.21%
GSA Capital Partners LLP — 0.19%
Learn More about top institutional investors of Spero Therapeutics stock.
Which institutional investors are selling Spero Therapeutics stock?: In the last quarter, SPRO stock was sold by these institutional investors:
Citadel Advisors LLC
Susquehanna International Group LLP
ADAR1 Capital Management LLC
Group One Trading LLC
Anson Funds Management LP
In the last year, company insiders that have sold Spero Therapeutics company stock include:
Sath Shukla (CEO)
Esther Rajavelu (Insider)
Ankit Mahadevia (Director)
Esther Rajavelu (CFO)
Learn More investors selling Spero Therapeutics stock.
Which institutional investors are buying Spero Therapeutics stock?: Within the previous quarter, SPRO stock was acquired by institutional investors including:
Arrowstreet Capital Limited Partnership
GSA Capital Partners LLP
Shay Capital LLC
Ionic Capital Management LLC
Two Sigma Investments LP
Vanguard Group Inc.
Assenagon Asset Management S.A.
Dimensional Fund Advisors LP