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SYRE Insider Trading

Insider Ownership Percentage: 15.43%
Insider Buying (Last 12 Months): $0.00
Insider Selling (Last 12 Months): $3,471,464.28

Spyre Therapeutics Insider Trading History Chart

This chart shows the insider buying and selling history at Spyre Therapeutics by year and by quarter.

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Spyre Therapeutics Share Price & Price History

Current Price: $41.25
Price Change: ▼ Price Decrease of -1.06 (-2.51%)
As of 03/20/2026 05:00 PM ET

This chart shows the closing price history over time for SYRE up to the past year.

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Days: 30 | 90 | 365

Spyre Therapeutics Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
3/3/2026Scott L. BurrowsCFOSell2,500$40.65$101,625.0097,994View SEC Filing Icon  
3/2/2026Cameron TurtleCEOSell15,000$42.19$632,850.00642,540View SEC Filing Icon  
2/2/2026Cameron TurtleCEOSell15,000$32.80$492,000.00657,540View SEC Filing Icon  
1/2/2026Cameron TurtleCEOSell15,000$30.68$460,200.00671,907View SEC Filing Icon  
12/1/2025Cameron TurtleCEOSell15,000$29.02$435,300.00686,907View SEC Filing Icon  
11/3/2025Cameron TurtleCEOSell45,000$23.33$1,049,850.00701,907View SEC Filing Icon  
9/2/2025Scott L. BurrowsCFOSell18,428$16.26$299,639.2897,994View SEC Filing Icon  
10/25/2024Jeffrey W. AlbersDirectorSell300$36.43$10,929.0034,060View SEC Filing Icon  
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SEC Filings (Institutional Ownership Changes) for Spyre Therapeutics (NASDAQ:SYRE)

80.39% of Spyre Therapeutics stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at SYRE by year and by quarter.

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Spyre Therapeutics Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
2/19/2026Invesco Ltd.150,934$4.95M0.0%+197.7%0.195%Search for SEC Filing on Google Icon
2/18/2026Mercer Global Advisors Inc. ADV106,316$3.48M0.0%-0.3%0.137%Search for SEC Filing on Google Icon
2/18/2026VARCOV Co.8,008$0.26M0.1%N/A0.010%Search for SEC Filing on Google Icon
2/18/2026Virtus Investment Advisers LLC7,913$0.26M0.1%+23.2%0.010%Search for SEC Filing on Google Icon
2/18/2026Wellington Management Group LLP1,549,284$50.76M0.0%-5.5%1.997%Search for SEC Filing on Google Icon
2/18/2026Susquehanna Portfolio Strategies LLC53,101$1.74M0.0%+144.3%0.068%Search for SEC Filing on Google Icon
2/18/2026Tang Capital Management LLC1,892,200$61.99M3.1%-40.9%2.439%Search for SEC Filing on Google Icon
2/18/2026Tudor Investment Corp ET AL10,127$0.33M0.0%N/A0.013%Search for SEC Filing on Google Icon
2/18/2026RTW Investments LP4,171,996$136.68M1.4%+15.2%5.377%Search for SEC Filing on Google Icon
2/18/2026Perceptive Advisors LLC3,069,225$100.55M1.8%+149.6%3.956%Search for SEC Filing on Google Icon
2/18/2026Millennium Management LLC76,194$2.50M0.0%-81.3%0.098%Search for SEC Filing on Google Icon
2/18/2026Janus Henderson Group PLC1,829,009$59.92M0.0%+13,969.3%2.357%Search for SEC Filing on Google Icon
2/18/2026Cinctive Capital Management LP35,935$1.18M0.1%N/A0.046%Search for SEC Filing on Google Icon
2/18/2026Commodore Capital LP2,388,245$78.24M5.2%+20.1%3.078%Search for SEC Filing on Google Icon
2/18/2026Balyasny Asset Management L.P.73,465$2.41M0.0%N/A0.095%Search for SEC Filing on Google Icon
2/18/2026Armistice Capital LLC196,426$6.44M0.1%+25.9%0.253%Search for SEC Filing on Google Icon
2/17/2026AQR Capital Management LLC17,820$0.58M0.0%+4.5%0.023%Search for SEC Filing on Google Icon
2/17/2026Braidwell LP1,634,615$53.55M1.7%-36.6%2.107%Search for SEC Filing on Google Icon
2/17/2026RA Capital Management L.P.1,621,620$53.12M0.5%N/A2.090%Search for SEC Filing on Google Icon
2/17/2026Price T Rowe Associates Inc. MD1,601,882$52.48M0.0%+158.1%2.065%Search for SEC Filing on Google Icon
2/17/2026California State Teachers Retirement System48,038$1.57M0.0%+44.7%0.062%Search for SEC Filing on Google Icon
2/17/2026Russell Investments Group Ltd.5,554$0.18M0.0%+31.2%0.007%Search for SEC Filing on Google Icon
2/17/2026State of Wisconsin Investment Board27,252$0.89M0.0%-18.8%0.035%Search for SEC Filing on Google Icon
2/17/2026ExodusPoint Capital Management LP37,871$1.24M0.0%-44.8%0.049%Search for SEC Filing on Google Icon
2/17/2026Royal Bank of Canada1,988$65K0.0%-74.8%0.003%Search for SEC Filing on Google Icon
2/17/2026Persistent Asset Partners Ltd2,246$74K0.0%N/A0.003%Search for SEC Filing on Google Icon
2/17/2026Polar Capital Holdings Plc740,326$24.25M0.1%-6.1%0.954%Search for SEC Filing on Google Icon
2/16/2026Barclays PLC182,524$5.98M0.0%+8.4%0.235%Search for SEC Filing on Google Icon
2/13/2026The Manufacturers Life Insurance Company 129,013$4.14M0.0%+79.3%0.166%Search for SEC Filing on Google Icon
2/13/2026Carlyle Group Inc.9,620$0.32M0.0%N/A0.012%Search for SEC Filing on Google Icon
2/13/2026Affinity Asset Advisors LLC1,432,591$46.93M2.7%+0.9%1.846%Search for SEC Filing on Google Icon
2/13/2026Schroder Investment Management Group61,574$1.96M0.0%-42.8%0.079%Search for SEC Filing on Google Icon
2/13/2026Rafferty Asset Management LLC53,410$1.75M0.0%-10.5%0.069%Search for SEC Filing on Google Icon
2/13/2026Siren L.L.C.818,598$26.82M0.8%+122.1%1.055%Search for SEC Filing on Google Icon
2/13/2026Charles Schwab Investment Management Inc.574,622$18.83M0.0%+35.1%0.741%Search for SEC Filing on Google Icon
2/13/2026Police & Firemen s Retirement System of New Jersey18,360$0.60M0.0%+33.0%0.024%Search for SEC Filing on Google Icon
2/13/2026State Street Corp2,262,839$74.13M0.0%+26.8%2.916%Search for SEC Filing on Google Icon
2/13/2026Martingale Asset Management L P6,930$0.23M0.0%N/A0.009%Search for SEC Filing on Google Icon
2/13/2026UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC62,216$2.04M0.0%+57.5%0.080%Search for SEC Filing on Google Icon
2/13/2026Wells Fargo & Company MN82,416$2.70M0.0%+109.6%0.106%Search for SEC Filing on Google Icon
2/12/2026Remedium Capital Partners LLC1,456,231$47.71M28.0%N/A1.877%Search for SEC Filing on Google Icon
2/12/2026MetLife Investment Management LLC38,011$1.25M0.0%+27.1%0.049%Search for SEC Filing on Google Icon
2/12/2026State Board of Administration of Florida Retirement System9,030$0.30M0.0%N/A0.012%Search for SEC Filing on Google Icon
2/12/2026Dimensional Fund Advisors LP77,290$2.53M0.0%-8.2%0.100%Search for SEC Filing on Google Icon
2/12/2026Patient Square Capital LP150,000$4.91M1.1%N/A0.193%Search for SEC Filing on Google Icon
2/12/2026New York State Common Retirement Fund19,165$0.63M0.0%+15.7%0.025%Search for SEC Filing on Google Icon
2/12/2026Alps Advisors Inc.63,708$2.09M0.0%N/A0.082%Search for SEC Filing on Google Icon
2/12/2026Swiss National Bank96,500$3.16M0.0%+37.5%0.124%Search for SEC Filing on Google Icon
2/12/2026Nuveen LLC150,980$4.95M0.0%+57.0%0.195%Search for SEC Filing on Google Icon
2/11/2026Deutsche Bank AG121,941$4M0.0%+216.4%0.157%Search for SEC Filing on Google Icon
2/11/2026Franklin Resources Inc.1,109,274$36.34M0.0%+39.5%1.430%Search for SEC Filing on Google Icon
2/11/2026Capital International Investors3,492,541$114.42M0.0%+46.0%4.501%Search for SEC Filing on Google Icon
2/11/2026Los Angeles Capital Management LLC12,882$0.42M0.0%-29.1%0.017%Search for SEC Filing on Google Icon
2/11/2026Arrowpoint Investment Partners Singapore Pte. Ltd.13,724$0.45M0.1%N/A0.018%Search for SEC Filing on Google Icon
2/10/2026TD Asset Management Inc149,822$4.91M0.0%+107.0%0.193%Search for SEC Filing on Google Icon
2/10/2026Goldman Sachs Group Inc.275,065$9.01M0.0%-16.5%0.355%Search for SEC Filing on Google Icon
2/10/2026Intech Investment Management LLC18,274$0.60M0.0%-10.2%0.024%Search for SEC Filing on Google Icon
2/10/2026Seven Grand Managers LLC100,000$3.28M0.2%N/A0.129%Search for SEC Filing on Google Icon
2/9/2026Geode Capital Management LLC1,659,140$54.36M0.0%+35.4%2.138%Search for SEC Filing on Google Icon
2/9/2026Optimize Financial Inc25,331$0.83M0.4%+1.5%0.033%Search for SEC Filing on Google Icon
2/6/2026PSP Research LLC15,840$0.52M0.5%N/A0.020%Search for SEC Filing on Google Icon
2/6/2026Profund Advisors LLC20,593$0.68M0.0%+55.7%0.027%Search for SEC Filing on Google Icon
2/6/2026ProShare Advisors LLC15,989$0.52M0.0%+49.7%0.021%Search for SEC Filing on Google Icon
2/4/2026VIRGINIA RETIREMENT SYSTEMS ET Al24,950$0.82M0.0%+34.9%0.032%Search for SEC Filing on Google Icon
2/3/2026F m Investments LLC103,718$3.40M0.1%+88.9%0.134%Search for SEC Filing on Google Icon
1/30/2026State of New Jersey Common Pension Fund D16,698$0.55M0.0%N/A0.022%Search for SEC Filing on Google Icon
1/29/2026Pictet Asset Management Holding SA913,960$29.94M0.0%-11.8%1.178%Search for SEC Filing on Google Icon
1/29/2026UBS Group AG680,566$22.30M0.0%+76.5%0.877%Search for SEC Filing on Google Icon
1/29/2026Vanguard Group Inc.4,035,074$132.19M0.0%+32.3%5.201%Search for SEC Filing on Google Icon
1/29/2026China Universal Asset Management Co. Ltd.12,644$0.41M0.0%+19.4%0.016%Search for SEC Filing on Google Icon
1/28/2026Arizona State Retirement System13,797$0.45M0.0%+29.0%0.018%Search for SEC Filing on Google Icon
1/28/2026Universal Beteiligungs und Servicegesellschaft mbH171,211$5.61M0.0%+55.0%0.221%Search for SEC Filing on Google Icon
1/26/2026Mirae Asset Global Investments Co. Ltd.3,770$0.12M0.0%+61.5%0.005%Search for SEC Filing on Google Icon
1/9/2026SG Americas Securities LLC23,343$0.77M0.0%N/A0.030%Search for SEC Filing on Google Icon
1/1/2026JPMorgan Chase & Co.275,984$4.63M0.0%+483.7%0.356%Search for SEC Filing on Google Icon
11/17/2025Armistice Capital LLC156,000$2.62M0.0%-9.3%0.201%Search for SEC Filing on Google Icon
11/17/2025Woodline Partners LP131,876$2.21M0.0%-71.6%0.170%Search for SEC Filing on Google Icon
11/17/2025TCG Crossover Management LLC1,100,582$18.45M0.9%N/A1.418%Search for SEC Filing on Google Icon
11/17/2025Dark Forest Capital Management LP14,733$0.25M0.0%N/A0.019%Search for SEC Filing on Google Icon
11/17/2025Verition Fund Management LLC48,496$0.81M0.0%-25.4%0.063%Search for SEC Filing on Google Icon
11/17/2025Polar Capital Holdings Plc788,788$13.22M0.1%+5.9%1.017%Search for SEC Filing on Google Icon
11/17/2025Paradigm Biocapital Advisors LP1,467,266$24.59M0.7%-21.6%1.891%Search for SEC Filing on Google Icon
11/17/2025Parkman Healthcare Partners LLC200,753$3.37M0.4%N/A0.259%Search for SEC Filing on Google Icon
11/17/2025Mercer Global Advisors Inc. ADV106,664$1.79M0.0%+0.5%0.137%Search for SEC Filing on Google Icon
11/17/2025Millennium Management LLC408,199$6.84M0.0%N/A0.526%Search for SEC Filing on Google Icon
11/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.26,448$0.44M0.0%-11.3%0.034%Search for SEC Filing on Google Icon
11/17/2025HighVista Strategies LLC215,746$3.62M0.9%+91.3%0.278%Search for SEC Filing on Google Icon
11/17/2025Baker BROS. Advisors LP1,000,000$16.76M0.1%+59.6%1.289%Search for SEC Filing on Google Icon
11/17/2025Bank of America Corp DE344,803$5.78M0.0%-13.0%0.444%Search for SEC Filing on Google Icon
11/14/2025Schonfeld Strategic Advisors LLC81,474$1.37M0.0%N/A0.135%Search for SEC Filing on Google Icon
11/14/2025Zurcher Kantonalbank Zurich Cantonalbank 10,874$0.18M0.0%-15.5%0.018%Search for SEC Filing on Google Icon
11/14/2025UBS AM A Distinct Business Unit of UBS Asset Management Americas LLC39,498$0.66M0.0%-53.9%0.065%Search for SEC Filing on Google Icon
11/14/2025Squarepoint Ops LLC20,232$0.34M0.0%-32.7%0.033%Search for SEC Filing on Google Icon
11/14/2025B Group Inc.100,000$1.68M1.3%+25.0%0.166%Search for SEC Filing on Google Icon
11/14/2025Wellington Management Group LLP1,640,312$27.49M0.0%+8.4%2.716%Search for SEC Filing on Google Icon
11/14/2025F m Investments LLC54,893$0.92M0.0%+4.5%0.091%Search for SEC Filing on Google Icon
11/13/2025UBS Group AG385,589$6.46M0.0%-16.7%0.638%Search for SEC Filing on Google Icon
11/13/2025BNP Paribas Financial Markets315,909$5.30M0.0%+41.5%0.523%Search for SEC Filing on Google Icon
11/13/2025Capital World Investors200,172$3.36M0.0%-42.9%0.331%Search for SEC Filing on Google Icon
11/13/2025Legal & General Group Plc46,841$0.79M0.0%+34.0%0.078%Search for SEC Filing on Google Icon
Data available starting January 2016

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Spyre Therapeutics logo
Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.
Read More on Spyre Therapeutics

Today's Range

Now: $41.25
Low: $41.16
High: $43.22

50 Day Range

MA: $37.31
Low: $31.53
High: $44.18

52 Week Range

Now: $41.25
Low: $10.91
High: $45.76

Volume

1,410,500 shs

Average Volume

827,203 shs

Market Capitalization

$3.24 billion

P/E Ratio

N/A

Dividend Yield

N/A

Beta

3.09

Who are the company insiders with the largest holdings of Spyre Therapeutics?

Spyre Therapeutics' top insider shareholders include:
  1. Cameron Turtle (CEO)
  2. Scott L Burrows (CFO)
  3. Jeffrey W Albers (Director)
Learn More about top insider investors at Spyre Therapeutics.

Who are the major institutional investors of Spyre Therapeutics?

Spyre Therapeutics' top institutional shareholders include:
  1. RTW Investments LP — 5.38%
  2. Vanguard Group Inc. — 5.20%
  3. Capital International Investors — 4.50%
  4. Perceptive Advisors LLC — 3.96%
  5. Commodore Capital LP — 3.08%
  6. State Street Corp — 2.92%
Learn More about top institutional investors of Spyre Therapeutics stock.

Which institutional investors are selling Spyre Therapeutics stock?

In the last quarter, SYRE stock was sold by these institutional investors:
  1. Tang Capital Management LLC
  2. Braidwell LP
  3. Millennium Management LLC
  4. Pictet Asset Management Holding SA
  5. Wellington Management Group LLP
  6. Goldman Sachs Group Inc.
  7. Polar Capital Holdings Plc
  8. Schroder Investment Management Group
In the previous year, company insiders that have sold Spyre Therapeutics company stock include:
  1. Cameron Turtle (CEO)
  2. Scott L Burrows (CFO)
Learn More investors selling Spyre Therapeutics stock.

Which institutional investors are buying Spyre Therapeutics stock?

In the last quarter, SYRE stock was bought by institutional investors including:
  1. Perceptive Advisors LLC
  2. Janus Henderson Group PLC
  3. RA Capital Management L.P.
  4. Remedium Capital Partners LLC
  5. Capital International Investors
  6. Vanguard Group Inc.
  7. Price T Rowe Associates Inc. MD
  8. RTW Investments LP