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SYRE Insider Trading

Insider Ownership Percentage: 15.69%
Insider Buying (Last 12 Months): $0.00
Insider Selling (Last 12 Months): $20,709,223.78

Spyre Therapeutics Insider Trading History Chart

This chart shows the insider buying and selling history at Spyre Therapeutics by year and by quarter.

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Spyre Therapeutics Share Price & Price History

Current Price: $88.34
Price Change: +0.30 (1.20%)
As of 06/18/2026 04:00 PM ET

This chart shows the closing price history over time for SYRE up to the past year.

Skip Chart and Table DataPrice Data in Insider Trading History Table
Days: 30 | 90 | 365

Spyre Therapeutics Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
6/3/2026Sheldon SloanInsiderSell8,333$75.00$624,975.008,333View SEC Filing Icon  
6/1/2026Cameron TurtleCEOSell15,000$70.43$1,056,450.00597,540View SEC Filing Icon  
6/1/2026Scott L. BurrowsCFOSell7,500$71.06$532,950.0097,994View SEC Filing Icon  
5/8/2026Michael Thomas HendersonDirectorSell80,000$74.40$5,952,000.0088,606View SEC Filing Icon  
5/1/2026Cameron TurtleCEOSell15,000$71.37$1,070,550.00612,540View SEC Filing Icon  
5/1/2026Scott L. BurrowsCFOSell12,500$71.37$892,125.0097,994View SEC Filing Icon  
5/1/2026Sheldon SloanInsiderSell78,333$71.50$5,600,809.5078,333View SEC Filing Icon  
4/1/2026Cameron TurtleCEOSell15,000$49.33$739,950.00627,540View SEC Filing Icon  
4/1/2026Scott L. BurrowsCFOSell7,500$49.34$370,050.0097,994View SEC Filing Icon  
4/1/2026Sheldon SloanInsiderSell7,958$50.00$397,900.007,958View SEC Filing Icon  
3/3/2026Scott L. BurrowsCFOSell2,500$40.65$101,625.0097,994View SEC Filing Icon  
3/2/2026Cameron TurtleCEOSell15,000$42.19$632,850.00642,540View SEC Filing Icon  
2/2/2026Cameron TurtleCEOSell15,000$32.80$492,000.00657,540View SEC Filing Icon  
1/2/2026Cameron TurtleCEOSell15,000$30.68$460,200.00671,907View SEC Filing Icon  
12/1/2025Cameron TurtleCEOSell15,000$29.02$435,300.00686,907View SEC Filing Icon  
11/3/2025Cameron TurtleCEOSell45,000$23.33$1,049,850.00701,907View SEC Filing Icon  
9/2/2025Scott L. BurrowsCFOSell18,428$16.26$299,639.2897,994View SEC Filing Icon  
10/25/2024Jeffrey W. AlbersDirectorSell300$36.43$10,929.0034,060View SEC Filing Icon  
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SEC Filings (Institutional Ownership Changes) for Spyre Therapeutics (NASDAQ:SYRE)

80.39% of Spyre Therapeutics stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at SYRE by year and by quarter.

Skip Institutional Buying and Selling Chart and Table DataRead Chart Data in Institutional Trading History Table

Spyre Therapeutics Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
6/4/2026Seven Fleet Capital Management LP19,690$0.99M0.3%N/A0.023%Search for SEC Filing on Google Icon
5/29/2026Perceptive Advisors LLC3,783,225$190.83M3.7%+23.3%4.357%Search for SEC Filing on Google Icon
5/19/2026Bank of America Corp DE1,228,093$61.95M0.0%+192.6%1.414%Search for SEC Filing on Google Icon
5/19/2026Stempoint Capital LP167,606$8.45M1.6%+417.7%0.193%Search for SEC Filing on Google Icon
5/19/2026Janus Henderson Group PLC1,656,164$83.59M0.0%-9.5%1.907%Search for SEC Filing on Google Icon
5/18/2026ADAR1 Capital Management LLC338,323$17.07M1.0%+893.6%0.390%Search for SEC Filing on Google Icon
5/18/2026California State Teachers Retirement System59,242$2.99M0.0%+23.3%0.068%Search for SEC Filing on Google Icon
5/18/2026Royal Bank of Canada3,250$0.16M0.0%+63.5%0.004%Search for SEC Filing on Google Icon
5/16/2026The Manufacturers Life Insurance Company 112,841$5.69M0.0%-12.5%0.130%Search for SEC Filing on Google Icon
5/16/2026Quantinno Capital Management LP4,561$0.23M0.0%N/A0.005%Search for SEC Filing on Google Icon
5/16/2026ABS Direct Equity Fund LLC2,800$0.14M0.1%N/A0.003%Search for SEC Filing on Google Icon
5/15/2026Commodore Capital LP1,912,380$96.46M5.6%-19.9%2.202%Search for SEC Filing on Google Icon
5/15/2026Affinity Asset Advisors LLC1,279,134$64.52M3.3%-10.7%1.473%Search for SEC Filing on Google Icon
5/14/2026Sei Investments Co.8,975$0.45M0.0%+46.7%0.010%Search for SEC Filing on Google Icon
5/13/2026First Trust Advisors LP178,389$9M0.0%N/A0.205%Search for SEC Filing on Google Icon
5/7/2026Dimensional Fund Advisors LP47,697$2.41M0.0%-38.3%0.061%Search for SEC Filing on Google Icon
5/7/2026AlphaCentric Advisors LLC6,634$0.34M0.3%N/A0.008%Search for SEC Filing on Google Icon
5/7/2026KBC Group NV1,372$69K0.0%N/A0.002%Search for SEC Filing on Google Icon
5/5/2026Bank of New York Mellon Corp191,395$9.65M0.0%-0.7%0.243%Search for SEC Filing on Google Icon
5/4/2026Emerald Mutual Fund Advisers Trust408,113$20.59M1.0%-1.0%0.518%Search for SEC Filing on Google Icon
5/4/2026Emerald Advisers LLC613,365$30.94M1.0%-3.6%0.779%Search for SEC Filing on Google Icon
5/4/2026Principal Financial Group Inc.4,299$0.22M0.0%N/A0.005%Search for SEC Filing on Google Icon
5/1/2026Candriam S.C.A.610,282$30.78M0.2%+43.4%0.775%Search for SEC Filing on Google Icon
4/30/2026Summit Securities Group LLC562$28K0.0%N/A0.001%Search for SEC Filing on Google Icon
4/25/2026Strs Ohio4,500$0.23M0.0%N/A0.006%Search for SEC Filing on Google Icon
4/22/2026Pictet Asset Management Holding SA491,649$24.80M0.0%-46.2%0.624%Search for SEC Filing on Google Icon
4/22/2026Union Bancaire Privee UBP SA3,880$0.20M0.0%N/A0.005%Search for SEC Filing on Google Icon
4/22/2026Sterling Capital Management LLC1,051$53K0.0%-34.7%0.001%Search for SEC Filing on Google Icon
4/20/2026Assenagon Asset Management S.A.18,647$0.94M0.0%-15.8%0.024%Search for SEC Filing on Google Icon
4/17/2026High Net Worth Advisory Group LLC6,000$0.30M0.1%N/A0.008%Search for SEC Filing on Google Icon
4/16/2026SG Americas Securities LLC13,396$0.68M0.0%-42.6%0.017%Search for SEC Filing on Google Icon
2/19/2026Invesco Ltd.150,934$4.95M0.0%+197.7%0.195%Search for SEC Filing on Google Icon
2/18/2026Mercer Global Advisors Inc. ADV106,316$3.48M0.0%-0.3%0.137%Search for SEC Filing on Google Icon
2/18/2026VARCOV Co.8,008$0.26M0.1%N/A0.010%Search for SEC Filing on Google Icon
2/18/2026Virtus Investment Advisers LLC7,913$0.26M0.1%+23.2%0.010%Search for SEC Filing on Google Icon
2/18/2026Wellington Management Group LLP1,549,284$50.76M0.0%-5.5%1.997%Search for SEC Filing on Google Icon
2/18/2026Susquehanna Portfolio Strategies LLC53,101$1.74M0.0%+144.3%0.068%Search for SEC Filing on Google Icon
2/18/2026Tang Capital Management LLC1,892,200$61.99M3.1%-40.9%2.439%Search for SEC Filing on Google Icon
2/18/2026Tudor Investment Corp ET AL10,127$0.33M0.0%N/A0.013%Search for SEC Filing on Google Icon
2/18/2026RTW Investments LP4,171,996$136.68M1.4%+15.2%5.377%Search for SEC Filing on Google Icon
2/18/2026Perceptive Advisors LLC3,069,225$100.55M1.8%+149.6%3.956%Search for SEC Filing on Google Icon
2/18/2026Millennium Management LLC76,194$2.50M0.0%-81.3%0.098%Search for SEC Filing on Google Icon
2/18/2026Janus Henderson Group PLC1,829,009$59.92M0.0%+13,969.3%2.357%Search for SEC Filing on Google Icon
2/18/2026Cinctive Capital Management LP35,935$1.18M0.1%N/A0.046%Search for SEC Filing on Google Icon
2/18/2026Commodore Capital LP2,388,245$78.24M5.2%+20.1%3.078%Search for SEC Filing on Google Icon
2/18/2026Balyasny Asset Management L.P.73,465$2.41M0.0%N/A0.095%Search for SEC Filing on Google Icon
2/18/2026Armistice Capital LLC196,426$6.44M0.1%+25.9%0.253%Search for SEC Filing on Google Icon
2/17/2026AQR Capital Management LLC17,820$0.58M0.0%+4.5%0.023%Search for SEC Filing on Google Icon
2/17/2026Braidwell LP1,634,615$53.55M1.7%-36.6%2.107%Search for SEC Filing on Google Icon
2/17/2026RA Capital Management L.P.1,621,620$53.12M0.5%N/A2.090%Search for SEC Filing on Google Icon
2/17/2026Price T Rowe Associates Inc. MD1,601,882$52.48M0.0%+158.1%2.065%Search for SEC Filing on Google Icon
2/17/2026California State Teachers Retirement System48,038$1.57M0.0%+44.7%0.062%Search for SEC Filing on Google Icon
2/17/2026Russell Investments Group Ltd.5,554$0.18M0.0%+31.2%0.007%Search for SEC Filing on Google Icon
2/17/2026State of Wisconsin Investment Board27,252$0.89M0.0%-18.8%0.035%Search for SEC Filing on Google Icon
2/17/2026ExodusPoint Capital Management LP37,871$1.24M0.0%-44.8%0.049%Search for SEC Filing on Google Icon
2/17/2026Royal Bank of Canada1,988$65K0.0%-74.8%0.003%Search for SEC Filing on Google Icon
2/17/2026Persistent Asset Partners Ltd2,246$74K0.0%N/A0.003%Search for SEC Filing on Google Icon
2/17/2026Polar Capital Holdings Plc740,326$24.25M0.1%-6.1%0.954%Search for SEC Filing on Google Icon
2/16/2026Barclays PLC182,524$5.98M0.0%+8.4%0.235%Search for SEC Filing on Google Icon
2/13/2026The Manufacturers Life Insurance Company 129,013$4.14M0.0%+79.3%0.166%Search for SEC Filing on Google Icon
2/13/2026Carlyle Group Inc.9,620$0.32M0.0%N/A0.012%Search for SEC Filing on Google Icon
2/13/2026Affinity Asset Advisors LLC1,432,591$46.93M2.7%+0.9%1.846%Search for SEC Filing on Google Icon
2/13/2026Schroder Investment Management Group61,574$1.96M0.0%-42.8%0.079%Search for SEC Filing on Google Icon
2/13/2026Rafferty Asset Management LLC53,410$1.75M0.0%-10.5%0.069%Search for SEC Filing on Google Icon
2/13/2026Siren L.L.C.818,598$26.82M0.8%+122.1%1.055%Search for SEC Filing on Google Icon
2/13/2026Charles Schwab Investment Management Inc.574,622$18.83M0.0%+35.1%0.741%Search for SEC Filing on Google Icon
2/13/2026Police & Firemen s Retirement System of New Jersey18,360$0.60M0.0%+33.0%0.024%Search for SEC Filing on Google Icon
2/13/2026State Street Corp2,262,839$74.13M0.0%+26.8%2.916%Search for SEC Filing on Google Icon
2/13/2026Martingale Asset Management L P6,930$0.23M0.0%N/A0.009%Search for SEC Filing on Google Icon
2/13/2026UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC62,216$2.04M0.0%+57.5%0.080%Search for SEC Filing on Google Icon
2/13/2026Wells Fargo & Company MN82,416$2.70M0.0%+109.6%0.106%Search for SEC Filing on Google Icon
2/12/2026Remedium Capital Partners LLC1,456,231$47.71M28.0%N/A1.877%Search for SEC Filing on Google Icon
2/12/2026MetLife Investment Management LLC38,011$1.25M0.0%+27.1%0.049%Search for SEC Filing on Google Icon
2/12/2026State Board of Administration of Florida Retirement System9,030$0.30M0.0%N/A0.012%Search for SEC Filing on Google Icon
2/12/2026Dimensional Fund Advisors LP77,290$2.53M0.0%-8.2%0.100%Search for SEC Filing on Google Icon
2/12/2026Patient Square Capital LP150,000$4.91M1.1%N/A0.193%Search for SEC Filing on Google Icon
2/12/2026New York State Common Retirement Fund19,165$0.63M0.0%+15.7%0.025%Search for SEC Filing on Google Icon
2/12/2026Alps Advisors Inc.63,708$2.09M0.0%N/A0.082%Search for SEC Filing on Google Icon
2/12/2026Swiss National Bank96,500$3.16M0.0%+37.5%0.124%Search for SEC Filing on Google Icon
2/12/2026Nuveen LLC150,980$4.95M0.0%+57.0%0.195%Search for SEC Filing on Google Icon
2/11/2026Deutsche Bank AG121,941$4M0.0%+216.4%0.157%Search for SEC Filing on Google Icon
2/11/2026Franklin Resources Inc.1,109,274$36.34M0.0%+39.5%1.430%Search for SEC Filing on Google Icon
2/11/2026Capital International Investors3,492,541$114.42M0.0%+46.0%4.501%Search for SEC Filing on Google Icon
2/11/2026Los Angeles Capital Management LLC12,882$0.42M0.0%-29.1%0.017%Search for SEC Filing on Google Icon
2/11/2026Arrowpoint Investment Partners Singapore Pte. Ltd.13,724$0.45M0.1%N/A0.018%Search for SEC Filing on Google Icon
2/10/2026TD Asset Management Inc149,822$4.91M0.0%+107.0%0.193%Search for SEC Filing on Google Icon
2/10/2026Goldman Sachs Group Inc.275,065$9.01M0.0%-16.5%0.355%Search for SEC Filing on Google Icon
2/10/2026Intech Investment Management LLC18,274$0.60M0.0%-10.2%0.024%Search for SEC Filing on Google Icon
2/10/2026Seven Grand Managers LLC100,000$3.28M0.2%N/A0.129%Search for SEC Filing on Google Icon
2/9/2026Geode Capital Management LLC1,659,140$54.36M0.0%+35.4%2.138%Search for SEC Filing on Google Icon
2/9/2026Optimize Financial Inc25,331$0.83M0.4%+1.5%0.033%Search for SEC Filing on Google Icon
2/6/2026PSP Research LLC15,840$0.52M0.5%N/A0.020%Search for SEC Filing on Google Icon
2/6/2026Profund Advisors LLC20,593$0.68M0.0%+55.7%0.027%Search for SEC Filing on Google Icon
2/6/2026ProShare Advisors LLC15,989$0.52M0.0%+49.7%0.021%Search for SEC Filing on Google Icon
2/4/2026VIRGINIA RETIREMENT SYSTEMS ET Al24,950$0.82M0.0%+34.9%0.032%Search for SEC Filing on Google Icon
2/3/2026F m Investments LLC103,718$3.40M0.1%+88.9%0.134%Search for SEC Filing on Google Icon
1/30/2026State of New Jersey Common Pension Fund D16,698$0.55M0.0%N/A0.022%Search for SEC Filing on Google Icon
1/29/2026Pictet Asset Management Holding SA913,960$29.94M0.0%-11.8%1.178%Search for SEC Filing on Google Icon
1/29/2026UBS Group AG680,566$22.30M0.0%+76.5%0.877%Search for SEC Filing on Google Icon
1/29/2026Vanguard Group Inc.4,035,074$132.19M0.0%+32.3%5.201%Search for SEC Filing on Google Icon
Data available starting January 2016

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Spyre Therapeutics logo
Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.
Read More on Spyre Therapeutics

Today's Range

Now: $88.34
Low: $86.18
High: $90.99

50 Day Range

MA: $73.21
Low: $51.29
High: $88.34

52 Week Range

Now: $88.34
Low: $14.00
High: $90.99

Volume

2,420,416 shs

Average Volume

1,072,921 shs

Market Capitalization

$7.67 billion

P/E Ratio

N/A

Dividend Yield

N/A

Beta

3.05

Who are the company insiders with the largest holdings of Spyre Therapeutics?

Spyre Therapeutics' top insider shareholders include:
  1. Cameron Turtle (CEO)
  2. Scott L Burrows (CFO)
  3. Michael Thomas Henderson (Director)
  4. Sheldon Sloan (Insider)
  5. Jeffrey W Albers (Director)
Learn More about top insider investors at Spyre Therapeutics.

Who are the major institutional investors of Spyre Therapeutics?

Spyre Therapeutics' top institutional shareholders include:
  1. Perceptive Advisors LLC — 4.36%
  2. Commodore Capital LP — 2.20%
  3. Janus Henderson Group PLC — 1.91%
  4. Affinity Asset Advisors LLC — 1.47%
  5. Bank of America Corp DE — 1.41%
  6. Emerald Advisers LLC — 0.78%
Learn More about top institutional investors of Spyre Therapeutics stock.

Which institutional investors are selling Spyre Therapeutics stock?

In the last quarter, SYRE stock was sold by these institutional investors:
  1. Commodore Capital LP
  2. Pictet Asset Management Holding SA
  3. Janus Henderson Group PLC
  4. Affinity Asset Advisors LLC
  5. Dimensional Fund Advisors LP
  6. Emerald Advisers LLC
  7. The Manufacturers Life Insurance Company
  8. SG Americas Securities LLC
In the previous year, company insiders that have sold Spyre Therapeutics company stock include:
  1. Cameron Turtle (CEO)
  2. Scott L Burrows (CFO)
  3. Michael Thomas Henderson (Director)
  4. Sheldon Sloan (Insider)
Learn More investors selling Spyre Therapeutics stock.

Which institutional investors are buying Spyre Therapeutics stock?

In the last quarter, SYRE stock was bought by institutional investors including:
  1. Bank of America Corp DE
  2. Perceptive Advisors LLC
  3. ADAR1 Capital Management LLC
  4. Candriam S.C.A.
  5. First Trust Advisors LP
  6. Stempoint Capital LP
  7. Seven Fleet Capital Management LP
  8. California State Teachers Retirement System

Spyre Therapeutics Active Insiders

Cameron Turtle
Cameron Turtle
CEO
6 recent trades
Scott L Burrows
Scott L Burrows
CFO
4 recent trades
Jeffrey W Albers
Jeffrey W Albers
Director
Michael Thomas Henderson
Michael Thomas Henderson
Director
1 recent trades
Sheldon Sloan
Sheldon Sloan
Chief Medical Officer
3 recent trades