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SYRE Insider Trading

Insider Ownership Percentage: 15.43%
Insider Buying (Last 12 Months): $0.00
Insider Selling (Last 12 Months): $1,349,489.28

Spyre Therapeutics Insider Trading History Chart

This chart shows the insider buying and selling history at Spyre Therapeutics by year and by quarter.

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Spyre Therapeutics Share Price & Price History

Current Price: $22.52
Price Change: ▲ Price Increase of +0.13 (0.58%)
As of 11/7/2025 05:00 PM ET

This chart shows the closing price history over time for SYRE up to the past year.

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Days: 30 | 90 | 365

Spyre Therapeutics Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
11/3/2025Cameron TurtleCEOSell45,000$23.33$1,049,850.00701,907View SEC Filing Icon  
9/2/2025Scott L. BurrowsCFOSell18,428$16.26$299,639.2897,994View SEC Filing Icon  
10/25/2024Jeffrey W. AlbersDirectorSell300$36.43$10,929.0034,060View SEC Filing Icon  
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SEC Filings (Institutional Ownership Changes) for Spyre Therapeutics (NASDAQ:SYRE)

80.39% of Spyre Therapeutics stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at SYRE by year and by quarter.

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Spyre Therapeutics Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
11/7/2025Vanguard Group Inc.3,050,730$51.13M0.0%-0.5%5.051%Search for SEC Filing on Google Icon
11/7/2025JPMorgan Chase & Co.275,984$4.63M0.0%+483.7%0.457%Search for SEC Filing on Google Icon
11/6/2025Rhumbline Advisers70,914$1.19M0.0%-3.1%0.117%Search for SEC Filing on Google Icon
11/6/2025Profund Advisors LLC13,223$0.22M0.0%+19.7%0.022%Search for SEC Filing on Google Icon
11/6/2025ProShare Advisors LLC10,678$0.18M0.0%-14.4%0.018%Search for SEC Filing on Google Icon
11/6/2025Candriam S.C.A.404,362$6.78M0.0%+64.4%0.669%Search for SEC Filing on Google Icon
11/5/2025Optimize Financial Inc24,967$0.42M0.2%N/A0.041%Search for SEC Filing on Google Icon
11/3/2025AlphaQuest LLC66,163$1.11M0.1%+1,485.1%0.110%Search for SEC Filing on Google Icon
10/30/2025Emerald Mutual Fund Advisers Trust308,212$5.17M0.3%-6.4%0.510%Search for SEC Filing on Google Icon
10/30/2025Universal Beteiligungs und Servicegesellschaft mbH110,456$1.85M0.0%+1.1%0.183%Search for SEC Filing on Google Icon
10/20/2025VIRGINIA RETIREMENT SYSTEMS ET Al18,500$0.31M0.0%N/A0.031%Search for SEC Filing on Google Icon
8/15/2025Tower Research Capital LLC TRC 5,769$86K0.0%+182.2%0.010%Search for SEC Filing on Google Icon
8/15/2025Rafferty Asset Management LLC50,957$0.76M0.0%-27.5%0.084%Search for SEC Filing on Google Icon
8/15/2025Perceptive Advisors LLC1,529,445$22.90M2.0%-33.9%2.532%Search for SEC Filing on Google Icon
8/15/2025Man Group plc10,843$0.16M0.0%N/A0.018%Search for SEC Filing on Google Icon
8/15/2025BNP Paribas Financial Markets223,320$3.34M0.0%+300.0%0.370%Search for SEC Filing on Google Icon
8/15/2025Bank of America Corp DE396,351$5.93M0.0%-7.2%0.656%Search for SEC Filing on Google Icon
8/15/2025Adage Capital Partners GP L.L.C.610,200$9.14M0.0%-24.0%1.010%Search for SEC Filing on Google Icon
8/14/2025California State Teachers Retirement System33,201$0.50M0.0%+1.8%0.055%Search for SEC Filing on Google Icon
8/14/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.29,812$0.45M0.0%+10.3%0.049%Search for SEC Filing on Google Icon
8/14/2025Armistice Capital LLC172,000$2.58M0.0%-14.0%0.285%Search for SEC Filing on Google Icon
8/14/2025The Manufacturers Life Insurance Company 79,896$1.20M0.0%+48.2%0.132%Search for SEC Filing on Google Icon
8/14/2025HighVista Strategies LLC112,805$1.69M0.6%+18.5%0.187%Search for SEC Filing on Google Icon
8/14/2025B Group Inc.80,000$1.20M0.9%+14.3%0.132%Search for SEC Filing on Google Icon
8/13/2025Affinity Asset Advisors LLC606,678$9.08M1.2%+26.0%1.004%Search for SEC Filing on Google Icon
8/13/2025Invesco Ltd.34,680$0.52M0.0%+37.6%0.057%Search for SEC Filing on Google Icon
8/13/2025New York State Common Retirement Fund16,565$0.25M0.0%+61.4%0.027%Search for SEC Filing on Google Icon
8/13/2025Schroder Investment Management Group129,558$1.97M0.0%+19.4%0.215%Search for SEC Filing on Google Icon
8/13/2025Virtus Investment Advisers LLC5,310$79K0.0%-22.6%0.009%Search for SEC Filing on Google Icon
8/13/2025F m Investments LLC52,546$0.79M0.0%+1.4%0.087%Search for SEC Filing on Google Icon
8/12/2025Foresite Capital Management VI LLC70,000$1.05M0.6%N/A0.116%Search for SEC Filing on Google Icon
8/12/2025Ameritas Investment Partners Inc.5,091$76K0.0%+25.8%0.008%Search for SEC Filing on Google Icon
8/12/2025Jefferies Financial Group Inc.1,388,854$20.79M0.2%+11.2%2.299%Search for SEC Filing on Google Icon
8/12/2025Rhumbline Advisers73,168$1.10M0.0%+30.6%0.121%Search for SEC Filing on Google Icon
8/12/2025Franklin Resources Inc.795,275$11.91M0.0%+4.6%1.317%Search for SEC Filing on Google Icon
8/12/2025Legal & General Group Plc34,969$0.52M0.0%-7.6%0.058%Search for SEC Filing on Google Icon
8/12/2025JPMorgan Chase & Co.47,279$0.71M0.0%+13.8%0.078%Search for SEC Filing on Google Icon
8/11/2025Universal Beteiligungs und Servicegesellschaft mbH109,284$1.64M0.0%-9.2%0.181%Search for SEC Filing on Google Icon
8/8/2025Intech Investment Management LLC24,945$0.37M0.0%+22.1%0.041%Search for SEC Filing on Google Icon
8/8/2025Police & Firemen s Retirement System of New Jersey11,525$0.17M0.0%+31.5%0.019%Search for SEC Filing on Google Icon
8/8/2025Geode Capital Management LLC1,227,232$18.37M0.0%+15.8%2.036%Search for SEC Filing on Google Icon
8/7/2025ProShare Advisors LLC12,479$0.19M0.0%+9.7%0.021%Search for SEC Filing on Google Icon
8/7/2025Profund Advisors LLC11,043$0.17M0.0%-24.7%0.018%Search for SEC Filing on Google Icon
8/4/2025Emerald Mutual Fund Advisers Trust329,430$4.93M0.3%-15.4%0.547%Search for SEC Filing on Google Icon
8/4/2025Emerald Advisers LLC565,863$8.47M0.3%+3.3%0.939%Search for SEC Filing on Google Icon
7/31/2025AlphaQuest LLC4,174$62K0.0%+30.8%0.007%Search for SEC Filing on Google Icon
7/28/2025TD Asset Management Inc113,968$1.71M0.0%+409.5%0.189%Search for SEC Filing on Google Icon
7/25/2025CWM LLC1,712$26K0.0%+357.8%0.003%Search for SEC Filing on Google Icon
6/27/2025Goldman Sachs Group Inc.197,068$3.18M0.0%-73.6%0.327%Search for SEC Filing on Google Icon
5/29/2025Rhumbline Advisers56,023$0.90M0.0%-2.8%0.093%Search for SEC Filing on Google Icon
5/23/2025Siren L.L.C.368,598$5.95M0.3%-1.4%0.612%Search for SEC Filing on Google Icon
5/16/2025Woodline Partners LP464,808$7.50M0.0%+31.8%0.771%Search for SEC Filing on Google Icon
5/16/2025Goldman Sachs Group Inc.197,068$3.18M0.0%-73.6%0.327%Search for SEC Filing on Google Icon
5/16/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.27,018$0.44M0.0%+18.8%0.045%Search for SEC Filing on Google Icon
5/16/2025Adage Capital Partners GP L.L.C.803,200$12.96M0.0%-22.0%1.333%Search for SEC Filing on Google Icon
5/16/2025ADAR1 Capital Management LLC15,033$0.24M0.0%N/A0.025%Search for SEC Filing on Google Icon
5/15/2025Paradigm Biocapital Advisors LP2,127,205$34.32M1.6%+39.3%3.529%Search for SEC Filing on Google Icon
5/15/2025Driehaus Capital Management LLC2,717,312$43.84M0.4%-3.1%4.508%Search for SEC Filing on Google Icon
5/15/2025Siren L.L.C.368,598$5.95M0.3%-1.4%0.612%Search for SEC Filing on Google Icon
5/14/2025Affinity Asset Advisors LLC481,678$7.77M0.7%-41.6%0.799%Search for SEC Filing on Google Icon
5/14/2025Rafferty Asset Management LLC70,323$1.14M0.0%-8.4%0.117%Search for SEC Filing on Google Icon
5/14/2025Corebridge Financial Inc.19,595$0.32M0.0%+13.8%0.033%Search for SEC Filing on Google Icon
5/14/2025MetLife Investment Management LLC23,733$0.38M0.0%+11.0%0.039%Search for SEC Filing on Google Icon
5/14/2025AlphaQuest LLC3,191$51K0.0%+45.2%0.005%Search for SEC Filing on Google Icon
5/14/2025Candriam S.C.A.246,030$3.97M0.0%-0.6%0.408%Search for SEC Filing on Google Icon
5/14/2025Wellington Management Group LLP1,593,678$25.71M0.0%-0.7%2.644%Search for SEC Filing on Google Icon
5/12/2025Nuveen LLC140,129$2.26M0.0%N/A0.232%Search for SEC Filing on Google Icon
5/12/2025Invesco Ltd.25,207$0.41M0.0%+28.2%0.042%Search for SEC Filing on Google Icon
5/9/2025Deutsche Bank AG28,483$0.46M0.0%-9.3%0.047%Search for SEC Filing on Google Icon
5/9/2025Charles Schwab Investment Management Inc.382,636$6.17M0.0%+0.8%0.635%Search for SEC Filing on Google Icon
5/9/2025Vanguard Group Inc.2,898,267$46.76M0.0%+1.8%4.808%Search for SEC Filing on Google Icon
5/8/2025Jefferies Financial Group Inc.1,248,854$20.15M0.2%+2.6%2.072%Search for SEC Filing on Google Icon
5/8/2025Natixis Advisors LLC16,401$0.27M0.0%-5.2%0.027%Search for SEC Filing on Google Icon
5/8/2025XTX Topco Ltd28,499$0.46M0.0%N/A0.047%Search for SEC Filing on Google Icon
5/7/2025TD Asset Management Inc22,368$0.36M0.0%-65.6%0.037%Search for SEC Filing on Google Icon
5/6/2025Universal Beteiligungs und Servicegesellschaft mbH120,321$1.94M0.0%-1.5%0.200%Search for SEC Filing on Google Icon
5/2/2025Victory Capital Management Inc.251,846$4.06M0.0%-6.1%0.418%Search for SEC Filing on Google Icon
5/1/2025Emerald Advisers LLC547,827$8.84M0.4%+0.2%0.909%Search for SEC Filing on Google Icon
5/1/2025Emerald Mutual Fund Advisers Trust389,422$6.28M0.4%+0.8%0.646%Search for SEC Filing on Google Icon
4/29/2025Bank of New York Mellon Corp114,240$1.84M0.0%+10.2%0.190%Search for SEC Filing on Google Icon
4/8/2025Rhumbline Advisers56,023$0.90M0.0%-2.8%0.093%Search for SEC Filing on Google Icon
4/7/2025GAMMA Investing LLC4,356$70K0.0%N/A0.007%Search for SEC Filing on Google Icon
3/24/2025Wellington Management Group LLP1,604,508$37.35M0.0%+6.5%2.663%Search for SEC Filing on Google Icon
3/18/2025California State Teachers Retirement System32,598$0.76M0.0%+32.1%0.054%Search for SEC Filing on Google Icon
2/28/2025Universal Beteiligungs und Servicegesellschaft mbH122,153$2.84M0.0%N/A0.238%Search for SEC Filing on Google Icon
2/19/2025GF Fund Management CO. LTD.1,232$29K0.0%N/A0.002%Search for SEC Filing on Google Icon
2/17/2025UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC48,981$1.14M0.0%+85.2%0.095%Search for SEC Filing on Google Icon
2/17/2025Voloridge Investment Management LLC115,470$2.69M0.0%-26.2%0.225%Search for SEC Filing on Google Icon
2/17/2025Woodline Partners LP352,680$8.21M0.1%+33.5%0.686%Search for SEC Filing on Google Icon
2/17/2025Squarepoint Ops LLC15,231$0.36M0.0%+79.7%0.030%Search for SEC Filing on Google Icon
2/17/2025RTW Investments LP3,621,996$84.32M1.3%+11.2%7.043%Search for SEC Filing on Google Icon
2/17/2025Rafferty Asset Management LLC76,740$1.79M0.0%+8.7%0.149%Search for SEC Filing on Google Icon
2/17/2025Polar Capital Holdings Plc750,000$17.46M0.1%+50.0%1.458%Search for SEC Filing on Google Icon
2/17/2025ProShare Advisors LLC12,531$0.29M0.0%N/A0.024%Search for SEC Filing on Google Icon
2/17/2025Prosight Management LP80,000$1.86M0.5%N/A0.156%Search for SEC Filing on Google Icon
2/17/2025Paradigm Biocapital Advisors LP1,527,205$35.55M1.2%+20.5%2.969%Search for SEC Filing on Google Icon
2/17/2025Millennium Management LLC167,804$3.91M0.0%N/A0.326%Search for SEC Filing on Google Icon
2/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.22,741$0.53M0.0%+4.2%0.044%Search for SEC Filing on Google Icon
2/17/2025Janus Henderson Group PLC1,456,740$33.93M0.0%+30.0%2.832%Search for SEC Filing on Google Icon
2/17/2025Jefferies Financial Group Inc.1,216,954$28.33M0.2%+167.6%2.366%Search for SEC Filing on Google Icon
Data available starting January 2016

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Spyre Therapeutics logo
Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.
Read More on Spyre Therapeutics

Today's Range

Now: $22.52
Low: $21.15
High: $22.54

50 Day Range

MA: $19.01
Low: $14.82
High: $24.64

52 Week Range

Now: $22.52
Low: $10.91
High: $40.26

Volume

569,245 shs

Average Volume

683,561 shs

Market Capitalization

$1.36 billion

P/E Ratio

N/A

Dividend Yield

N/A

Beta

2.99

Who are the company insiders with the largest holdings of Spyre Therapeutics?

Spyre Therapeutics' top insider shareholders include:
  1. Cameron Turtle (CEO)
  2. Scott L Burrows (CFO)
  3. Jeffrey W Albers (Director)
Learn More about top insider investors at Spyre Therapeutics.

Who are the major institutional investors of Spyre Therapeutics?

Spyre Therapeutics' top institutional shareholders include:
  1. Vanguard Group Inc. — 5.05%
  2. Candriam S.C.A. — 0.67%
  3. Emerald Mutual Fund Advisers Trust — 0.51%
  4. JPMorgan Chase & Co. — 0.46%
  5. Universal Beteiligungs und Servicegesellschaft mbH — 0.18%
  6. Rhumbline Advisers — 0.12%
Learn More about top institutional investors of Spyre Therapeutics stock.

Which institutional investors are selling Spyre Therapeutics stock?

In the last quarter, SYRE stock was sold by these institutional investors:
  1. Emerald Mutual Fund Advisers Trust
  2. Vanguard Group Inc.
  3. Rhumbline Advisers
  4. ProShare Advisors LLC
In the previous year, company insiders that have sold Spyre Therapeutics company stock include:
  1. Cameron Turtle (CEO)
  2. Scott L Burrows (CFO)
Learn More investors selling Spyre Therapeutics stock.

Which institutional investors are buying Spyre Therapeutics stock?

In the last quarter, SYRE stock was bought by institutional investors including:
  1. JPMorgan Chase & Co.
  2. Candriam S.C.A.
  3. AlphaQuest LLC
  4. Optimize Financial Inc
  5. VIRGINIA RETIREMENT SYSTEMS ET Al
  6. Profund Advisors LLC
  7. Universal Beteiligungs und Servicegesellschaft mbH